Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for by genes for the variable (V) region of the immunoglobulin heavy (H) chains. In B cells, a complete gene for the immunoglobulin VH region is formed by somatic recombination of VH and joining region heavy chain (JH) gene segments [through an interme...
GH3 cells normally synthesize and secrete two pituitary polypeptide hormones, prolactin and growth hormone. From an ethyl methane sulfonate-mutagenized population, prolactin low-producing variants have been isolated at a frequency near 20%. Intracellular prolactin synthesis in the variants was reduced 40- to 100-fold compared to wild-type cells whi...
Human a1-antitrypsin (a-1-AT;Pi) production was analyzed in 11 primary mouse hepatoma-human lymphoid cell hybrids and in 14 secondary rat hepatoma-human fetal liver fibroblast hybrids. The presence of human a-l-AT was determined by Laurell immunoelectrophoresis of oncentrated and isotopically labeled supernatant medium. Human a-i-AT production segr...
Human a1-antitrypsin (a-1-AT;Pi) production was analyzed in 11 primary mouse hepatoma-human lymphoid cell hybrids and in 14 secondary rat hepatoma-human fetal liver fibroblast hybrids. The presence of human a-l-AT was determined by Laurell immunoelectrophoresis of oncentrated and isotopically labeled supernatant medium. Human a-i-AT production segr...
Human a1-antitrypsin (a-1-AT;Pi) production was analyzed in 11 primary mouse hepatoma-human lymphoid cell hybrids and in 14 secondary rat hepatoma-human fetal liver fibroblast hybrids. The presence of human a-l-AT was determined by Laurell immunoelectrophoresis of oncentrated and isotopically labeled supernatant medium. Human a-i-AT production segr...
Human a1-antitrypsin (a-1-AT;Pi) production was analyzed in 11 primary mouse hepatoma-human lymphoid cell hybrids and in 14 secondary rat hepatoma-human fetal liver fibroblast hybrids. The presence of human a-l-AT was determined by Laurell immunoelectrophoresis of oncentrated and isotopically labeled supernatant medium. Human a-i-AT production segr...
Human a1-antitrypsin (a-1-AT;Pi) production was analyzed in 11 primary mouse hepatoma-human lymphoid cell hybrids and in 14 secondary rat hepatoma-human fetal liver fibroblast hybrids. The presence of human a-l-AT was determined by Laurell immunoelectrophoresis of oncentrated and isotopically labeled supernatant medium. Human a-i-AT production segr...
Human a1-antitrypsin (a-1-AT;Pi) production was analyzed in 11 primary mouse hepatoma-human lymphoid cell hybrids and in 14 secondary rat hepatoma-human fetal liver fibroblast hybrids. The presence of human a-l-AT was determined by Laurell immunoelectrophoresis of oncentrated and isotopically labeled supernatant medium. Human a-i-AT production segr...
Human a1-antitrypsin (a-1-AT;Pi) production was analyzed in 11 primary mouse hepatoma-human lymphoid cell hybrids and in 14 secondary rat hepatoma-human fetal liver fibroblast hybrids. The presence of human a-l-AT was determined by Laurell immunoelectrophoresis of oncentrated and isotopically labeled supernatant medium. Human a-i-AT production segr...
Human a1-antitrypsin (a-1-AT;Pi) production was analyzed in 11 primary mouse hepatoma-human lymphoid cell hybrids and in 14 secondary rat hepatoma-human fetal liver fibroblast hybrids. The presence of human a-l-AT was determined by Laurell immunoelectrophoresis of oncentrated and isotopically labeled supernatant medium. Human a-i-AT production segr...
