Formation and removal of disinfection by-products in a full scale drinking water treatment plant
Biotransformation of silver released from nanoparticle coated titanium implants revealed in regenerating bone
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Antimicrobial silver nanoparticle coatings have attracted interest for reducing prosthetic joint infection. However, few studies report in vivo investigations of the biotransformation of silver nanoparticles within the regenerating tissue and its impact on bone formation. We present a longitudinal investigation of the osseointegration of silver nan...
Assessment of toxicity in fresh water fish Labeo rohita treated with silver nanoparticles
Published in Applied Nanoscience
Silver nanoparticles (17.78 ± 12.12 nm) were synthesized by the reduction of 0.5 M silver nitrate using formaldehyde as reducing and triethylamine as promoting and stabilizing agent. The particles were grain like agglomerates with spherical, centered-face cubic and crystalline in nature. The sample was highly pure with amine (NH) as associated and ...
Detection and toxicity evaluation of pyrrolizidine alkaloids in medicinal plants Gynura bicolor and Gynura divaricata co...
Two edible plants in Southeast Asia, Gynura bicolor and G.divaricata, are not only known to be nutritive but also useful as medicinal herbs. Previous phytochemical investigation of Gynura species showed the presence of hepatotoxic pyrrolizidine alkaloids (PAs), indicating the toxic risk of using these two plants. The present study was designed to a...
The influence of blood storage time and general anaesthesia on chromosomal radiosensitivity assessment
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The micronucleus assay (MN assay) is a well-established assay in genetic toxicology, biomonitoring of mutagen-exposed populations and chromosomal radiosensitivity testing. To evaluate the effect of storage time on the chromosomal radiosensitivity assessment in lymphocytes, micronuclei (MN) yields in blood samples received and processed on the same ...
Evaluation of QSAR models for the prediction of ames genotoxicity: a retrospective exercise on the chemical substances r...
Published in Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
We evaluated the performance of seven freely available quantitative structure-activity relationship models predicting Ames genotoxicity thanks to a dataset of chemicals that were registered under the EU Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation. The performance of the models was estimated according to C...
Effects of depleted uranium on the reproductive success and F1 generation survival of zebrafish (Danio rerio)
Despite the well-characterized occurrence of uranium (U) in the aquatic environment, very little is known about the chronic exposure of fish to low levels of U and its potential effect on reproduction. Therefore, this study was undertaken to investigate the effects of environmental concentrations of depleted U on the reproductive output of zebrafis...
In Vitro Glucuronidation of Ochratoxin A by Rat Liver Microsomes
Ochratoxin A (OTA), one of the most toxic mycotoxins, can contaminate a wide range of food and feedstuff. To date, the data on its conjugates via glucuronidation request clarification and consolidation. In the present study, the combined approaches of ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), UHPLC-Orbitra...
Dietary carotenoid lutein protects against DNA damage and alterations of the redox status induced by cisplatin in human ...
Several epidemiological and experimental studies has been reported that lutein (LT) presents antioxidant properties. Aim of the present study was to investigate the protective effects of LT against oxidative stress and DNA damage induced by cisplatin (cDDP) in a human derived liver cell line (HepG2). Cell viability and DNA-damage was monitored by M...
Dietary carotenoid lutein protects against DNA damage and alterations of the redox status induced by cisplatin in human ...
Several epidemiological and experimental studies has been reported that lutein (LT) presents antioxidant properties. Aim of the present study was to investigate the protective effects of LT against oxidative stress and DNA damage induced by cisplatin (cDDP) in a human derived liver cell line (HepG2). Cell viability and DNA-damage was monitored by M...
