Perucca, Piero; Anderson, Alison; Jazayeri, Dana; Hitchcock, Alison; Graham, Janet; Todaro, Marian; Tomson, Torbjorn; Battino, Dina; Perucca, Emilio; Ferri, Meritxell Martinez;
...
OBJECTIVE: The mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown. Data suggest that AED-induced BDs may result from a genome-wide increase of de novo variants in the embryo, a mechanism that we investigated. METHODS: Whole exome sequencing data from child-parent trios were interrogated for de novo single-nucleotid...
Mackeown, Henry Gyamfi, Junias Schoutteten, Klaas Vital Kaat Marnix Dumoulin, David Verdickt, Liesbeth Ouddane, Baghdad CRIQUET, JUSTINE
13 In this case study, high sensitivity simple methods for the analysis of trihalomethanes (THM4), 14 iodinated-trihalomethanes (I-THMs), haloacetic acids (HAAs), bromide, iodide and iodate have been 15 developed. A one-step procedure for the analysis of haloacetic acids by head-space GC-MS provides 16 good reproducibility and low limits of quantif...
Benetti, Giulio; 106647; Cavaliere, Emanuele; Brescia, Rosaria; Salassi, Sebastian; Ferrando, Riccardo; Vantomme, Andre; 17105; Pallecchi, Lucia; Pollini, Simona; Boncompagni, Selene; Fortuni, Beatrice; 92436;
...
Bactericidal nanoparticle coatings are very promising for hindering the indirect transmission of pathogens through cross-contaminated surfaces. The challenge, limiting their employment in nosocomial environments, is the ability of tailoring the coating's physicochemical properties, namely, composition, cytotoxicity, bactericidal spectrum, adhesion ...
Öner, Deniz; 93043; Ghosh, Manosij; 95907; Moisse, Matthieu; 73403; Duca, Radu Corneliu; 96643; Vanoirbeek, Jeroen; 33170; Lambrechts, Diether; 33562; Godderis, Lode; 5874; Hoet, Peter; 11607;
Inhalation exposure to asbestos is associated with lung and pleural diseases in humans and remains a major public health issue worldwide. Human bronchial epithelial cells (16HBE) were exposed to UICC amosite, crocidolite and chrysotile. Cytotoxicity, genotoxicity, global DNA methylation on cytosine residues (using LC-MS/MS) were investigated at dif...
Geng, H Poologasundarampillai, G Todd, N Devlin-Mullin, A Moore, KL Goirokhi, Z Gilchrist, JB Jones, E Potter, RJ Sutcliffe, C
...
Antimicrobial silver nanoparticle coatings have attracted interest for reducing prosthetic joint infection. However, few studies report in vivo investigations of the biotransformation of silver nanoparticles within the regenerating tissue and its impact on bone formation. We present a longitudinal investigation of the osseointegration of silver nan...
Khan, Muhammad Saleem Qureshi, Naureen Aziz Jabeen, Farhat
Published in
Applied Nanoscience
Silver nanoparticles (17.78 ± 12.12 nm) were synthesized by the reduction of 0.5 M silver nitrate using formaldehyde as reducing and triethylamine as promoting and stabilizing agent. The particles were grain like agglomerates with spherical, centered-face cubic and crystalline in nature. The sample was highly pure with amine (NH) as associated and ...
Chen, Jian Lü, Han Fang, Lian-Xiang Li, Wei-Lin Verschaeve, Luc Wang, Zheng-Tao De Kimpe, Norbert Mangelinckx, Sven
Published in
Chemistry & biodiversity
Two edible plants in Southeast Asia, Gynura bicolor and G. divaricata, are not only known to be nutritive but also useful as medicinal herbs. Previous phytochemical investigation of Gynura species showed the presence of hepatotoxic pyrrolizidine alkaloids (PAs), indicating the toxic risk of using these two plants. The present study was designed to ...
Baeyens, Ans Herd, Olivia Francies, Flavia Zita Cairns, Alan Katzman, Gary Murdoch, Marshall Padiachy, Dineshree Morford, Mike Vral, Anne Slabbert, Jacobus P
...
Published in
Mutagenesis
The micronucleus assay (MN assay) is a well-established assay in genetic toxicology, biomonitoring of mutagen-exposed populations and chromosomal radiosensitivity testing. To evaluate the effect of storage time on the chromosomal radiosensitivity assessment in lymphocytes, micronuclei (MN) yields in blood samples received and processed on the same ...
Cassano, Antonio Raitano, Giuseppa Mombelli, Enrico Fernández, Alberto Cester, Josep Roncaglioni, Alessandra Benfenati, Emilio
Published in
Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
We evaluated the performance of seven freely available quantitative structure-activity relationship models predicting Ames genotoxicity thanks to a dataset of chemicals that were registered under the EU Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation. The performance of the models was estimated according to C...
Bourrachot, Stéphanie Brion, François Pereira, Sandrine Floriani, Magali Camilleri, Virginie Cavalie, Isabelle Palluel, Olivier Adam-Guillermin, Christelle
Despite the well-characterized occurrence of uranium (U) in the aquatic environment, very little is known about the chronic exposure of fish to low levels of U and its potential effect on reproduction. Therefore, this study was undertaken to investigate the effects of environmental concentrations of depleted U on the reproductive output of zebrafis...