Quach, M Edward Syed, Anum K Li, Renhao
Published in
Journal of visualized experiments : JoVE
Many biological cells/tissues sense the mechanical properties of their local environments via mechanoreceptors, proteins that can respond to forces like pressure or mechanical perturbations. Mechanoreceptors detect their stimuli and transmit signals via a great diversity of mechanisms. Some of the most common roles for mechanoreceptors are in neuro...
van Geffen, Johanna P Brouns, Sanne LN Batista, Joana McKinney, Harriet Kempster, Carly Nagy, Magdolna Sivapalaratnam, Suthesh Baaten, Constance CFMJ Bourry, Nikki Frontini, Mattia
...
Wu, Zhiqiang Wang, Chenchen Huang, Mingzhu Tao, Zhonghua Yan, Wangjun Du, Yiqun
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Sesquiterpene lactones have gained tremendous attention owing to their potent anticancer properties. The main focus of this study was to evaluate the anticancer effects of a naturally occurring sesquiterpene lactone, santonin, against human breast cancer SK-BR-3 cells. Material/Methods Cell counting kit 8 assay was used for the determina...
Esposito, Ilaria
The Wnt signalling pathways are ways of signalling that transduce signals into cells through cell surface receptors; they are three different type of pathways and all of these are activated by binding a Wnt-protein ligand to a Frizzled family receptor. Frizzled is a family of G-protein coupled receptor proteins that works as receptor in the Wnt sig...
Xia, Xiaoyu Lo, Yu-Chen Gholkar, Ankur A Senese, Silvia Ong, Joseph Y Velasquez, Erick F Damoiseaux, Robert Torres, Jorge Z
Targeting the leukemia proliferation cycle has been a successful approach to developing antileukemic therapies. However, drug screening efforts to identify novel antileukemic agents have been hampered by the lack of a suitable high-throughput screening platform for suspension cells that does not rely on flow-cytometry analyses. We report the develo...
Moloudi, R Oh, S Yang, C Teo, KL Lam, ATL Ebrahimi Warkiani, M Win Naing, M
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Recently, particle concentration and filtration using inertial microfluidics have drawn attention as an alternative to membrane and centrifugal technologies for industrial applications, where the target particle size varies between 1 µm and 500 µm. Inevitably, the bigger particle size (>50 µm) manda...
Al Moosawi, Muntadhar Bruyère, Hélène
Review on t(6;8)(p21;q24), with data on clinics, and the genes involved.
Li, Jie Røise, Joachim Justad Zhang, Jingtuo Yang, Jiaying Kerr, D Lucas Han, Hesong Murthy, Niren
In this report, we designed and synthesized a novel fluorescent single tailed surfactant (termed FEDS), which can disrupt endosomes, complex lipofectamine, and can also identify cells that have been transfected. FEDS was able to increase the gene editing efficiency of lipofectamine/Cas9 ribonucleoprotein by 300% via a combination of fluorescent bas...
Hu, Zicheng Glicksberg, Benjamin S Butte, Atul J
MotivationFlow cytometry and mass cytometry are widely used to diagnose diseases and to predict clinical outcomes. When associating clinical features with cytometry data, traditional analysis methods require cell gating as an intermediate step, leading to information loss and susceptibility to batch effects. Here, we wish to explore an alternative ...
Zhu, Zhen Xiao, Tianyu Chang, Xuejiao Hua, Yanfei Gao, Jinli
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Liver cancer is one of the most commonly diagnosed cancers across the globe. The treatment is often difficult as it is diagnosed mostly at advanced stages. Moreover, the lack efficacious and less toxic drugs are another problem in the treatment of liver cancer. Against this background, in this study we evaluated the anticancer activity o...