Busuttil-Crellin, Xavier McCafferty, Conor Van Den Helm, Suelyn Yaw, Hui Ping Monagle, Paul Linden, Matthew Ignjatovic, Vera
Published in
Platelets
Flow cytometry is a valuable tool in determining the phenotype and function of platelets accurately. The emergence of platelet flow cytometry in recent years provides an attractive alternative to other platelet analytical techniques, with advantages such as requiring small volumes and being highly sensitive to minimal changes in receptor function a...
Chan, Stephrene S. W. Christopher, Dheepa Tan, Guat B. Chong, Vanessa C. L. Fan, Bingwen E. Lin, Clement Y. Ong, Kiat H.
Published in
International Journal of Laboratory Hematology
Pflug, James M. Holmes, Valerie Renee Burrus, Crystal Johnston, J. Spencer Maddison, David R.
Published in
G3: Genes|Genomes|Genetics
Measuring genome size across different species can yield important insights into evolution of the genome and allow for more informed decisions when designing next-generation genomic sequencing projects. New techniques for estimating genome size using shallow genomic sequence data have emerged which have the potential to augment our knowledge of gen...
Ngo, Tony Stephens, Bryan S Gustavsson, Martin Holden, Lauren G Abagyan, Ruben Handel, Tracy M Kufareva, Irina
Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets. Yet one of the barriers for their therapeutic targeting is the limited understanding of the structural principles ...
Kumar, Jyoti
X-linked thrombocytopenia (XLT) is a rare bleeding disorder characterized by isolated thrombocytopenia with small-sized platelets. XLT is a milder clinical variant of Wiskott-Aldrich syndrome (WAS), which is characterized by the clinical triad of eczema, susceptibility to infection and thrombocytopenia, while patients with XLT only present with thr...
Beri, Pranjali Popravko, Anna Yeoman, Benjamin Kumar, Aditya Chen, Kevin Hodzic, Enio Chiang, Alyssa Banisadr, Afsheen Placone, Jesse K Carter, Hannah
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Tumors are heterogeneous and composed of cells with different dissemination abilities. Despite significant effort, there is no universal biological marker that serves as a metric for metastatic potential of solid tumors. Common to disseminating cells from such tumors, however, is the need to modulate their adhesion as they detach from the tumor and...
Li, Wang Ping, Zhou Xuemei, Gao Minglian, Luo Hongjuan, Meng Yi, He Zhongxiang, Zhu
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Cervical cancer is a major threat to female health worldwide. This study was performed to study the anticancer potential of sclareol and as a chemo-sensitizing agent against human cervical cancer cells along with evaluating its effects on apoptosis, cell cycle arrest, and MAPK/ERK signaling pathway. Material/Methods MTT assay was perform...
Hou, Jian Yue, Yuan Hu, Bo Xu, Guangtao Su, Ruibing Lv, Linhua Huang, Jiaxing Yao, Jianping Guan, Yuanjun Wang, Keke
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Published in
Brazilian journal of cardiovascular surgery
To determine the role of the dishevelled binding antagonist of beta catenin 1 (DACT1) in the cytoskeletal arrangement of cardiomyocytes in atrial fibrillation (AF). The DACT1 expression and its associations with the degree of fibrosis and β-catenin in valvular disease patients were analyzed by immunohistochemistry and Masson's staining. DACT1 was o...
Ramsey-Goldman, Rosalind Alexander, Roberta Vezza Massarotti, Elena M Wallace, Daniel J Narain, Sonali Arriens, Cristina Collins, Christopher E Saxena, Amit Putterman, Chaim Kalunian, Kenneth C
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OBJECTIVE:To evaluate the frequency of cell-bound complement activation products (CB-CAPs) as a marker of complement activation in patients with suspected systemic lupus erythematosus (SLE) and the usefulness of this biomarker as a predictor of the evolution of probable SLE into SLE as classified by the American College of Rheumatology (ACR) criter...
Plach, Maximilian Schubert, Thomas
Published in
Advances in biochemical engineering/biotechnology
Aptamers are single-stranded nucleic acid molecules forming well-defined 3D structures. Aptamers typically bind to their ligands with high affinity and specificity. They are capable of interacting with various kinds of ligands: ions, small molecules, peptides, proteins, viruses, bacteria, and even cells. Therefore, aptamers are in widespread use as...
