Lejuez, C.W. Forsyth, John P. Eifert, Georg H.
Published in
Journal of Behavior Therapy and Experimental Psychiatry
Although researchers successfully have used carbon dioxide-enriched air in experimental and clinical preparations, its functional properties may differ across laboratories due to procedural differences. Additionally, current procedures may be too simplistic for more complex experimental designs. To address these issues, we present three devices for...
Forsyth, John P Palav, Anjali Duff, Kevin
Published in
Behaviour Research and Therapy
Anxiety sensitivity has been implicated as a risk factor in the development and maintenance of anxiety and fear-related disorders. Indeed, persons who score high on the anxiety sensitivity index (ASI) are generally more responsive to biological challenge procedures such as CO 2-inhalation that directly evoke the feared bodily events. One would expe...
Morrison, Adrian R. Sanford, Larry D. Ross, Richard J.
Published in
Neurosignals
The influence of external stimuli and the memories of both unpleasant and pleasant conditions clearly can have a considerable impact on the quality of sleep. The amygdala, a structure that plays an important role in coding the emotional significance of stimuli and is heavily interconnected with brainstem nuclei known to be involved in sleep control...
Conrad, C D Mauldin-Jourdain, M L Hobbs, R J
Published in
Stress (Amsterdam, Netherlands)
Chronic stress facilitates fear conditioning in rats with hippocampal neuronal atrophy and in rats in which the atrophy is prevented with tianeptine, a serotonin re-uptake enhancer. The purpose of this study was to determine whether the lack of dissociation between fear conditioning performance and hippocampal integrity was masked by the presence o...
Pine, Daniel S Fyer, Abby Grun, Joseph Phelps, Elizabeth A Szeszko, Philip R Koda, Vivian Li, Wei Ardekani, Babak Maguire, Eleanor A Burgess, Neil
...
Published in
Biological Psychiatry
Psychophysiologic studies use air puff as an aversive stimulus to document abnormal fear conditioning in children of parents with anxiety disorders. This study used functional magnetic resonance imaging (fMRI) to examine changes in amygdala activity during air-puff conditioning among adults. Blood oxygen level-dependent (BOLD) signal was monitored ...
Roy, Kristine Thiels, Edda Monaghan, A Paula
Published in
Physiology & behavior
We are studying the role of the evolutionarily conserved tlx gene in forebrain development in mice. Tlx is expressed in the ventricular zone that gives rise to neurons and glia of the forebrain. We have shown by mutating the tlx gene in mice, that in the absence of this transcription factor, mutant animals survive, but suffer specific anatomical de...
Fischer, André Sananbenesi, Farahnaz Spiess, Joachim Radulovic, Jelena
Published in
Neurosignals
Learning and memory are processes by which organisms acquire, retain and retrieve information. They result in modifications of behavior in response to new or previously encountered stimuli thereby enabling adaptation to a permanently changing environment. Protein phosphorylation has long been known to play a key role in triggering synaptic changes ...
Palomo, T. Beninger, R. J. Kostrzewa, R. M. Archer, T.
Published in
Neurotoxicity Research
A multitude of factors, that either singly, interactively, or sequentially influence the gene-environment interplay in affective and dementia states, include several phases of neurodevelopmental liability in both humans and laboratory animals. Genetic vulnerability for both affective disorders and dementia describes a scenario distinguished by prog...
Burghardt, Nesha S. Sullivan, Gregory M. McEwen, Bruce S. Gorman, Jack M. LeDoux, Joseph E.
Published in
Biological Psychiatry
Background Selective serotonin reuptake inhibitors (SSRIs) are efficacious in the treatment of a variety of fear or anxiety disorders. Although they inhibit the reuptake of serotonin within hours of administration, therapeutic improvement only occurs after several weeks. In this study, we used fear conditioning to begin to understand how acute and ...
Grillon, Christian Cordova, Jeremy Morgan, Charles Andrew III Charney, Dennis S. Davis, Michael
Published in
Psychopharmacology
RationaleBeta-adrenergic receptors are involved in the consolidation of emotional memories. Yet, a number of studies using Pavlovian cued fear conditioning have been unable to demonstrate an effect of beta-adrenergic blockade on acquisition or retention of fear conditioning. Evidence for the involvement of beta-adrenergic receptors in emotional mem...
