Sohn, Jeferson Machado Batista de Souza, Suzen Tortato Furtado Raymundi, Ana Maria Bonato, Jéssica de Oliveira, Rúbia Maria Weffort Prickaerts, Jos Stern, Cristina Aparecida
Published in
Neurobiology of learning and memory
Fear extinction is a form of new learning that inhibits expression of the original fear memory without erasing the conditioned stimulus-unconditioned stimulus association. Much is known about the mechanisms that underlie the acquisition of extinction, but the way in which fear extinction is maintained has been scarcely explored. Evidence suggests t...
Ojala, Karita E Bach, Dominik R
Published in
Neuroscience and biobehavioral reviews
Threat conditioning is a laboratory model of associative learning across species that is often used in research on the etiology and treatment of anxiety disorders. At least 10 different conditioned responses (CR) for quantifying learning in human threat conditioning are found in the literature. In this narrative review, we discuss these CR by consi...
Marks, Wendie N Zabder, Nadine K Snutch, Terrance P Howland, John G
Published in
Behavioural brain research
The T-type calcium channel blocker, Z944, has been used as a pharmacological tool to assess T-type calcium channel function and examined for use as an anti-epileptic. As Z944 affects fear learning and memory in a rodent model of absence epilepsy, it is important to determine the effect of Z944 on learning and memory in a non-disease outbred rodent ...
Wong, Alex H K Pittig, Andre
Published in
Behaviour research and therapy
Fear generalization refers to the spread of acquired fear to novel stimuli that resemble the original fear-related stimulus. Preliminary evidence suggests that excessive fear generalization is a pathogenic feature of anxiety disorders, however, it remains unclear how fear generalization affects pathological avoidance. The current study thus aimed t...
Shibano, Natsumi Yamazaki, Mio Arima, Tomoki Abe, Konami Kuroda, Marin Kobayashi, Yuki Itohara, Shigeyoshi Furuichi, Teiichi Sano, Yoshitake
Published in
Scientific Reports
Animals can remember a situation associated with an aversive event. Contextual fear memory is initially encoded and consolidated in the hippocampus and gradually consolidated in multiple brain regions over time, including the medial prefrontal cortex (PFC). However, it is not fully understood how PFC neurons contribute to contextual fear memory for...
Lissemore, Jennifer I. Nagano-Saito, Atsuko Smart, Kelly Gravel, Paul Leyton, Marco Benkelfat, Chawki
Published in
Scientific Reports
When a cue no longer predicts a threat, a diminished ability to extinguish or reverse this association is thought to increase risk for stress-related disorders. Despite the clear clinical relevance, the mediating neurochemical mechanisms of threat reversal have received relatively little study. One neurotransmitter implicated in rodent research of ...
Ridderbusch, Isabelle C Yang, Yunbo Weber, Heike Reif, Andreas Herterich, Sabine Ströhle, Andreas Pfleiderer, Bettina Arolt, Volker Wittchen, Hans-Ulrich Lueken, Ulrike
...
Published in
NeuroImage. Clinical
Neuronal nitric oxide synthase (NOS-I) impacts on fear/anxiety-like behavior in animals. In humans, the short (S) allele of a functional promotor polymorphism of NOS1 (NOS1 ex1f-VNTR) has been shown to be associated with higher anxiety and altered fear conditioning in healthy subjects in the amygdala and hippocampus (AMY/HIPP). Here, we explore the...
Day, Harriet L. L. Suwansawang, Sopapun Halliday, David M. Stevenson, Carl W.
Published in
Scientific Reports
The increased prevalence of post-traumatic stress disorder (PTSD) that is observed in women may involve sex differences in learned fear inhibition and medial prefrontal cortex (mPFC) function. PTSD is characterized by fear overgeneralization involving impaired fear regulation by safety signals. We recently found that males show fear discrimination ...
Robble, Mykel A Holloway, Isaiah L Jr Ridener, Elysia Webber, Chelsea J Caine, S Barak Meloni, Edward G Desai, Rajeev I Carlezon, William A Jr
Published in
International Journal of Neuropsychopharmacology
Background Tobacco use is prevalent in individuals who are routinely exposed to stress. However, little is known about how nicotine affects responses to trauma. We examined in rats how nicotine exposure affects fear conditioning, a procedure often used to study stress-related psychiatric illness. Methods We examined 2 methods of nicotine exposure: ...
Hirota, Yu Arai, Aki Young, Larry J Osako, Yoji Yuri, Kazunari Mitsui, Shinichi
Published in
Hormones and behavior
Social relationships among spouses, family members, and friends are known to affect physical and mental health. In particular, long-lasting bonds between socio-sexual partners have profound effects on cognitive, social, emotional, and physical well-being. We have previously reported that pair bonding in monogamous prairie voles (Microtus ochrogaste...
