Trombetta, Amelia Chiara Soldano, Stefano Contini, Paola Tomatis, Veronica Ruaro, Barbara Paolino, Sabrina Brizzolara, Renata Montagna, Paola Sulli, Alberto Pizzorni, Carmen
...
Published in
Respiratory Research
BackgroundSystemic sclerosis (SSc) is a disorder characterized by immune system alterations, vasculopathy and fibrosis. SSc-related interstitial lung disease (ILD) represents a common and early complication, being the leading cause of mortality.Monocytes/macrophages seem to have a key role in SSc-related ILD. Interestingly, the classically (M1) and...
Perez-Bogerd, Silvia Wuyts, Wim Barbier, Veronica Demeyer, Heleen Van Muylem, Alain Janssens, Wim Troosters, Thierry
Published in
Respiratory Research
BackgroundFew data are available on the long-term effect of pulmonary rehabilitation (PR) and on long PR programs in interstitial lung diseases (ILD).We aimed to evaluate the effects of PR on exercise capacity (6-Minute Walking Distance, 6MWD; Peak Work Rate, Wmax), quality of life (St George’s Respiratory Questionnaire, SGRQ), quadriceps force (QF...
Brandsma, Joost Goss, Victoria M. Yang, Xian Bakke, Per S. Caruso, Massimo Chanez, Pascal Dahlén, Sven-Erik Fowler, Stephen J. Horvath, Ildiko Krug, Norbert
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Published in
Metabolomics
BackgroundLung epithelial lining fluid (ELF)—sampled through sputum induction—is a medium rich in cells, proteins and lipids. However, despite its key role in maintaining lung function, homeostasis and defences, the composition and biology of ELF, especially in respect of lipids, remain incompletely understood.ObjectivesTo characterise the induced ...
Mallia, Patrick Webber, Jessica Gill, Simren K Trujillo-Torralbo, Maria-Belen Calderazzo, Maria Adelaide Finney, Lydia Bakhsoliani, Eteri Farne, Hugo Singanayagam, Aran Footitt, Joseph
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Published in
The Journal of allergy and clinical immunology
Patients with chronic obstructive pulmonary disease (COPD) have increased susceptibility to respiratory tract infection, which contributes to disease progression and mortality, but mechanisms of increased susceptibility to infection remain unclear. The aim of this study was to determine whether glucose concentrations were increased in airway sample...
Eastwood, Mary Patrice; 92852; Deprest, Jan; 31972; Russo, Francesca Maria; 101714; Wang, Hongmei; Mulhall, Drew; Iwasiow, Barbara; Mahood, Thomas H; Keijzer, Richard;
OBJECTIVE: Profiling of miR-200b expression and its targets (transforming growth factor [TGF]-β2 and ZEB2) in the surgical rabbit congenital diaphragmatic hernia (DH) model before and after tracheal occlusion (TO). METHODS: Thirty-eight timed-pregnant rabbits had left DH creation on gestational day (GD) 23. On GD28, 17 randomly selected fetuses had...
De Kock, Isabelle Delrue, Louke Hindryckx, Pieter
Published in
The lancet. Gastroenterology & hepatology
Ciaccio, EJ Peters, NS Garan, H
BACKGROUND: Atrial fibrillation (AF) is the most common heart arrhythmia, and permanent AF is an intractable medical problem. If cessation of permanent AF were possible, via extensive substrate ablation or multisite stimulation, it could significantly improve the public health. METHOD: A cellular automaton composed of 576 × 576 computerized grid no...
Cutolo, Maurizio Soldano, Stefano Montagna, Paola Trombetta, Amelia Chiara Contini, Paola Ruaro, Barbara Sulli, Alberto Scabini, Stefano Stratta, Emanuela Paolino, Sabrina
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Published in
Arthritis Research & Therapy
BackgroundSystemic sclerosis (SSc) is characterized by vasculopathy and progressive fibrosis. CTLA4-Ig (abatacept) is able to interact with the cell surface costimulatory molecule CD86 and downregulate the target cell. The aim of this study was to evaluate the in-vitro effects of CTLA4-Ig treatment on circulating fibrocytes and skin fibroblasts iso...
Cutolo, Maurizio Ruaro, Barbara Montagna, Paola Brizzolara, Renata Stratta, Emanuela Trombetta, Amelia Chiara Scabini, Stefano Tavilla, Pier Paolo Parodi, Aurora Corallo, Claudio
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Published in
Arthritis Research & Therapy
BackgroundMyofibroblasts contribute to fibrosis through the overproduction of extracellular matrix (ECM) proteins, primarily type I collagen (COL-1) and fibronectin (FN), a process which is mediated in systemic sclerosis (SSc) by the activation of fibrogenic intracellular signaling transduction molecules, including extracellular signal-regulated ki...
Stephen, Joanna M. Sopher, Ran Tullie, Sebastian Amis, Andrew A. Ball, Simon Williams, Andy
Published in
Knee Surgery, Sports Traumatology, Arthroscopy
PurposeThe infrapatellar fat pad (IFP) is a common cause of knee pain and loss of knee flexion and extension. However, its anatomy and behavior are not consistently defined.MethodsThirty-six unpaired fresh frozen knees (median age 34 years, range 21–68) were dissected, and IFP attachments and volume measured. The rectus femoris was elevated, suprap...
