Cutolo, Maurizio Soldano, Stefano Montagna, Paola Trombetta, Amelia Chiara Contini, Paola Ruaro, Barbara Sulli, Alberto Scabini, Stefano Stratta, Emanuela Paolino, Sabrina
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Published in
Arthritis Research & Therapy
BackgroundSystemic sclerosis (SSc) is characterized by vasculopathy and progressive fibrosis. CTLA4-Ig (abatacept) is able to interact with the cell surface costimulatory molecule CD86 and downregulate the target cell. The aim of this study was to evaluate the in-vitro effects of CTLA4-Ig treatment on circulating fibrocytes and skin fibroblasts iso...
Stephen, Joanna M. Sopher, Ran Tullie, Sebastian Amis, Andrew A. Ball, Simon Williams, Andy
Published in
Knee Surgery, Sports Traumatology, Arthroscopy
PurposeThe infrapatellar fat pad (IFP) is a common cause of knee pain and loss of knee flexion and extension. However, its anatomy and behavior are not consistently defined.MethodsThirty-six unpaired fresh frozen knees (median age 34 years, range 21–68) were dissected, and IFP attachments and volume measured. The rectus femoris was elevated, suprap...
Yang, Guang Zhuang, Xiahai Khan, Habib Haldar, Shouvik Nyktari, Eva Li, Lei Wage, Ricardo Ye, Xujiong Slabaugh, Greg Mohiaddin, Raad
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Published in
Medical physics
Atrial fibrillation (AF) is the most common heart rhythm disorder and causes considerable morbidity and mortality, resulting in a large public health burden that is increasing as the population ages. It is associated with atrial fibrosis, the amount and distribution of which can be used to stratify patients and to guide subsequent electrophysiology...
Ferraioli, G De Silvestri, A Reiberger, T Taylor-Robinson, SD De Knegt, RJ Maiocchi, L Mare, R Bucsics, T Atzori, S Tinelli, C
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BACKGROUND: Assessment of liver stiffness provides important diagnostic and prognostic information in patients with chronic liver disease. AIMS: To investigate whether the use of quality criteria (i) improves the concordance between transient elastography (TE) and a novel point shear wave elastography technique (ElastPQ®) and (ii) impacts on the pe...
Stock, Emmelie Duchateau, Luc Saunders, Jimmy H Volckaert, Veerle Polis, Ingeborgh Vanderperren, Katrien
Published in
Ultrasound in medicine & biology
Contrast-enhanced ultrasound can be used to image and quantify tissue perfusion. It holds great potential for the use in the diagnosis of various diffuse renal diseases in both human and veterinary medicine. Nevertheless, the technique is known to have an inherent relatively high variability, related to various factors associated with the patient, ...
Huber, Adrian T Lamy, Jérôme Rahhal, Amer Evin, Morgane Atassi, Fabrice Defrance, Carine Lebreton, Guillaume Clément, Karine Berthet, Myriam Isnard, Richard
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Published in
Radiology
Purpose To determine whether left atrial (LA) strain quantification with cardiac magnetic resonance (MR) imaging feature tracking is associated with the severity of LA fibrofatty myocardial remodeling at histologic analysis. Materials and Methods This prospective case-control study was approved by the institutional review board. LA strain was evalu...
De Kock, Isabelle Delrue, Louke Hindryckx, Pieter
Limandjaja, Grace C van den Broek, Lenie J Breetveld, Melanie Waaijman, Taco Monstrey, Stan de Boer, Edith M Scheper, Rik J Niessen, Frank B Gibbs, Susan
To understand scar pathology, develop new drugs, and provide a platform for personalized medicine, physiologically relevant human scar models are required, which are characteristic of different scar pathologies. Hypertrophic scars and keloids are two types of abnormal scar resulting from unknown abnormalities in the wound healing process. While the...
Reebye, V Huang, K-W Lin, V Jarvis, S Cutilas, P Dorman, S Ciriello, S Andrikakou, P Voutila, J Saetrom, P
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Liver diseases are a growing epidemic worldwide. If unresolved, liver fibrosis develops and can lead to cirrhosis and clinical decompensation. Around 5% of cirrhotic liver diseased patients develop hepatocellular carcinoma (HCC), which in its advanced stages has limited therapeutic options and negative survival outcomes. CEPBA is a master regulator...
Devisscher, Lindsey Scott, Charlotte L Lefere, Sander Raevens, Sarah Bogaerts, Eliene Paridaens, Annelies Verhelst, Xavier Geerts, Anja Guilliams, Martin Van Vlierberghe, Hans
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Published in
Cellular immunology
Kupffer cells (KCs) and monocyte-derived macrophages are implicated in non-alcoholic steatohepatitis (NASH) pathogenesis but their functions remain unclear due to the lack of specific markers to distinguish between the different cell types. Additionally, it is unclear if multiple subsets of KCs are present during NASH. Here, we characterized the li...
