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Svedberg, Freya Brown, Sheila L Krauss, Maria Z Campbell, Laura Sharpe, Catherine Clausen, Maryam Howell, Gareth J Clark, Howard Madsen, Jens Evans, Christopher M
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Fine control of macrophage activation is needed to prevent inflammatory disease, particularly at barrier sites such as the lungs. However, the dominant mechanisms that regulate the activation of pulmonary macrophages during inflammation are poorly understood. We found that alveolar macrophages (AlvMs) were much less able to respond to the canonical...
Machiels, Bénédicte Dourcy, Mickael Xiao, Xue Javaux, Justine Mesnil, Claire Sabatel, Catherine Desmecht, Daniel Lallemand, François Martinive, Philippe Hammad, Hamida
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The hygiene hypothesis postulates that the recent increase in allergic diseases such as asthma and hay fever observed in Western countries is linked to reduced exposure to childhood infections. Here we investigated how infection with a gammaherpesvirus affected the subsequent development of allergic asthma. We found that murid herpesvirus 4 (MuHV-4...
Lambrecht, Bart
Tissue-resident macrophages shape the development and homeostasis of the organs that they colonize. Yu et al. (2017) demonstrate that, unique to the lung, the instructive cytokine TGF-beta collaborates with GM-CSF to induce the master transcription factor PPAR gamma to drive alveolar macrophage differentiation and maintenance early in life.
Guilliams, Martin Scott, Charlotte
Most tissue-resident macrophages are derived from embryonic precursors but, under certain circumstances, circulating monocytes can differentiate into self-maintaining tissue-resident macrophages that resemble their embryonic counterparts. In this Opinion article, we propose that distinct macrophage precursors have an almost identical potential to d...
Scott, Charlotte Zheng, Fang De Baetselier, Patrick Martens, Liesbet Saeys, Yvan De Prijck, Sofie Lippens, Saskia Abels, Chloé Schoonooghe, Steve Raes, Geert
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Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-resident Kupffer cells to generate niche availability an...
Bain, Calum C Hawley, Catherine A Garner, Hannah Scott, Charlotte Schridde, Anika Steers, Nicholas J Mack, Matthias Joshi, Anagha Guilliams, Martin Mowat, Allan Mc I
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Peritoneal macrophages are one of the most studied macrophage populations in the body, yet the composition, developmental origin and mechanisms governing the maintenance of this compartment are controversial. Here we show resident F4/80(hi)GATA6(+) macrophages are long-lived, undergo non-stochastic self-renewal and retain cells of embryonic origin ...
Guilliams, Martin Lambrecht, Bart