Cancer biology & therapy
Objective: The study aimed to investigate candidate circular RNAs (circRNAs) in regulating the pathogenic process of esophageal carcinoma. Methods: Specimens were collected from the patients with esophageal carcinoma. Total RNA was purified and treated with RNase R followed by RNA-seq in the purpose of screening the circRNAs in significant differen...
Background/Aims: This study documents the clinical efficacy and toxicity of S-1 and paclitaxel (S1/PTX) in patients with unresectable or postoperative recurrent esophageal squamous cell carcinoma (ESCC) who had been previously treated with fluorouracil (5FU), cisplatin, and docetaxel. Methods: Twenty-eight ESCC patients treated using S1/PTX at our ...
Background: The correlation between O-6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation and esophageal cancer remains controversial. This study was conducted to evaluate the clinical effect of MGMT promoter methylation on esophageal carcinoma patients. Methods: A literature search was conducted in the PubMed, EMBASE, EBSCO, and Coch...
Für Adenokarzinome des ösophagogastralen Übergangs (AEG) hat sich die Klassifikation nach Siewert mit seinen drei Subtypen als pragmatischer Ansatz für die chirurgische Therapie durchgesetzt. Bei Adenokarzinomen des distalen Ösophagus (AEG Typ I) ist die transthorakale Ösophagektomie mit Magenhochzug chirurgischer Standard. Die gastrale Rekonstrukt...
Experimental cell research
Abundant evidence indicates that long noncoding RNAs (lncRNAs) play an important role in various cellular processes, tumorigenesis, and the development of cancer. An increasing number studies are exploring this lncRNA-mediated mechanism. CASC2 is a novel gene in lncRNAs, located at chromosome 10q26. The present study aimed to examine the expression...
BackgroundDedicated stents for treatment of cervical anastomotic leakage are currently unavailable. In this study, we aimed to assess the feasibility and efficacy of using custom-designed stents for treatment of cervical anastomotic leakage after esophagectomy.MethodsThe stents were designed according to the location and size of the leakage and the...
BackgroundMetastasis to the esophagus is a rare event that can occur by direct infiltration of malignancies from nearby organs or, more infrequently, via lymphatic or hematogenous spread.MethodsWe reviewed the hospital charts of a patient presenting with dysphagia in whom a distant metastasis to the esophagus from a primary lung adenocarcinoma was ...
Infectious Agents and Cancer
BackgroundEsophageal carcinoma (EC) is one of the major cancers in China. In 1982, Syrjanen first hypothesized the relationship between human papillomavirus (HPV) infection and the development of esophageal cancer. Since then, many reports in the field have supported this viewpoint. This study investigated the etiological relationship between HPV i...
Esophageal cancer commonly has a poor prognosis, which requires an accurate diagnosis and early treatment to improve outcome. Other modalities for staging, such as endoscopic ultrasound imaging and computed tomography (CT) scans, have a role in diagnosis and staging. However, PET with fluorine-18 fluoro-2-deoxy-d-glucose/CT (FDG PET/CT) scanning al...
Photodiagnosis and photodynamic therapy
This study revealed a molecular mechanism of ALA-PDT and developed a new modality application of therapy, by combining ALA-PDT with small molecular inhibitors, for better effect in the clinical practice of esophageal carcinoma.