Tang, Bin Huang, Dan Wang, Jun Luo, Lin-Lin Li, Qiu-Gen
Published in
Medical science monitor : international medical journal of experimental and clinical research
BACKGROUND The 2018 Global Initiative for Chronic Obstructive Lung Disease Report reveals that the blood eosinophil count could forecast the risk of flare-ups. This study explored the correlations of blood eosinophils with fractional exhaled nitric oxide (FeNO) and pulmonary function parameters in acute exacerbation of chronic obstructive pulmonary...
Loffredo, Lucas F. Coden, Mackenzie E. Jeong, Brian M. Walker, Matthew T. Anekalla, Kishore Reddy Doan, Ton C. Rodriguez, Raul Browning, Mandy Nam, Kiwon Lee, James J.
...
Published in
Scientific Reports
Type 2 immune cells and eosinophils are transiently present in the lung tissue not only in pathology (allergic disease, parasite expulsion) but also during normal postnatal development. However, the lung developmental processes underlying airway recruitment of eosinophils after birth remain unexplored. We determined that in mice, mature eosinophils...
Magat, Jenna M Thomas, Joanna L Dumouchel, Justin P Murray, Fiona Li, Willis X Li, Jinghong
IL-33 and its receptor ST2 are contributing factors to airway inflammation and asthma exacerbation. The IL-33/ST2 signaling pathway is involved in both the onset and the acute exacerbations of asthma. In this study, we address the role of endogenous IL-33 and its autoamplification of the IL-33/ST2 pathway in Ag-dependent and Ag-independent asthma-l...
Oliveira, Bárbara M. Pinto, Ana Correia, Alexandra Ferreira, Paula G. Vilanova, Manuel Teixeira, Luzia
Published in
Scientific Reports
Immune cells resident in adipose tissue have important functions in local and systemic metabolic homeostasis. Nevertheless, these immune cell populations remain poorly characterized in bovines. Recently, we described diverse lymphocyte subpopulations in adipose tissue of Holstein-Friesian cows. Here, we aimed at characterising myeloid cell populati...
Jackson, David J Humbert, Marc Hirsch, Ian Newbold, Paul Garcia Gil, Esther
Published in
Advances in therapy
Many patients with severe asthma have elevated numbers of eosinophils (a subset of white blood cells) and raised serum concentrations of immunoglobulin E (IgE; antibodies). Elevated eosinophil counts together with IgE concentrations are associated with more frequent asthma attacks. Benralizumab is a drug that almost completely depletes eosinophils ...
LEITE, Carine MAZZOLENI, Luiz Edmundo UCHOA, Diego de Mendonça CASTANHO, Juliana Araújo MAZZOLENI, Felipe SANDER, Guilherme Becker
ABSTRACT BACKGROUND: The role of Helicobacter pylori infection on eosinophilic infiltration in duodenal mucosa is poorly studied. An increase in the number of eosinophils in duodenum has been associated with functional dyspepsia. OBJECTIVE: To evaluate the influence of H. pylori infection on duodenal eosinophil count and the role of eosinophilic in...
Vanharen, Marion Girard, Denis
Published in
Inflammation
It is becoming increasingly clear that nanoparticles (NPs) possess many potential applications in both clinical medicine and research. Potential utilization of NPs in nanomedicine for the treatment of respiratory diseases where eosinophils exert pathogenic roles is gaining increasing attention. Even though several NPs were found to possess pro-infl...
Oka, Aiko Ninomiya, Takahiro Fujiwara, Tazuko Takao, Soshi Sato, Yasuharu Gion, Yuka Minoura, Akira Haruna, Shin-ichi Yoshida, Naohiro Sakuma, Yasunori
...
Background: Type 2 chronic rhinosinusitis (CRS), especially eosinophilic CRS (ECRS), is an intractable upper airway inflammatory disease. Establishment of serum biomarkers reflecting the pathophysiology of CRS is desirable in a clinical setting. As IgG4 production is regulated by type 2 cytokines, we sought to determine whether serum IgG4 levels ca...
Vega Villanueva, Karen L. Espinoza, Luis R.
Published in
Current Rheumatology Reports
Purpose of ReviewEosinophilic granulomatosis with polyangiitis (EGPA) represents a rare clinical entity, which is getting increasing attention and relevance in view of our better understanding and newer insights into its pathogenesis. Concomitantly better recognition and understanding of the immune pathophysiologic role of eosinophils provide a sol...
Bafadhel, Mona Singh, Dave Jenkins, Christine Peterson, Stefan Bengtsson, Thomas Wessman, Peter Fagerås, Malin
Published in
Respiratory Research
BackgroundClinically Important Deterioration (CID) is a novel composite measure to assess treatment effect in chronic obstructive pulmonary disease (COPD). We examined the performance and utility of CID in assessing the effect of inhaled corticosteroids (ICS) in COPD.MethodsThis post-hoc analysis of four budesonide/formoterol (BUD/FORM) studies com...
