Published in Oncoimmunology
In many types of cancer, presence of eosinophils in tumors correlate with an improved disease outcome. In line with this, activated eosinophils have been shown to reduce tumor growth in colorectal cancer (CRC). Interleukin (IL)-33 has recently emerged as a cytokine that is able to inhibit the development of tumors through eosinophils and other cell...
Published in Nature Communications
Immune cells are important regulators of adipose tissue function, including adaptive thermogenesis. Here the authors show that mice with Krüppel-like factor 3 (KLF3) deficiency in bone marrow-derived cells have increased adipose tissue beiging which may at least in part be due to altered eosinophil paracrine signaling.
Published in The Korean Journal of Internal Medicine
Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed. Nevertheless, 5% to 10% of adult asthmatic patients (called severe asthma) are in uncontrolled or partially controlled status despite int...
Published in Current Allergy and Asthma Reports
Purpose of ReviewThere has been an explosion of monoclonal antibodies in the treatment of severe uncontrolled adult asthma. Studies have now been published in severe pediatric asthma. There are numerous questions that need to be answered in determining whether these modalities are appropriate and safe in children.Recent FindingsThis is a narrative ...
Published in Asthma Research and Practice
BackgroundAnti-IgE (omalizumab) and anti-IL5/IL5R (reslizumab, mepolizumab and benralizumab) treatments are available for severe allergic and eosinophilic asthma. In these patients, studies have shown beneficial effects in oral corticosteroid use and exacerbations. The aim of this retrospective single-center study was to evaluate the effect of biol...
Published in Journal of Oral and Maxillofacial Pathology : JOMFP
Background: Stromal response to cancer is usually characterized by intense lymphoplasmacytic infiltrate. However, recently, the attention has shifted to tumor-associated tissue eosinophils (TATE). Tumor-associated blood eosinophils (TABE) are rare in solid cancers; however, carcinoma of the head and neck shows its prevalence. Aim: The aim of the st...
Published in The American Journal of Case Reports
Patient: Female, 55-year-old Final Diagnosis: Eosinophilic angiocentric fibrosis Symptoms: Lid swelling Medication: Topical eye drops Clinical Procedure: Resection of conjunctivas Specialty: Ophthalmology Objective: Rare disease Background: Eosinophilic angiocentric fibrosis (EAF) is an extremely rare disease with characteristic histopathological f...
Published in Tuberculosis and Respiratory Diseases
Blood eosinophil counts have emerged as a chronic obstructive pulmonary disease (COPD) biomarker that predict the effects of inhaled corticosteroids (ICS) in clinical practice. Post-hoc and prospective analysis of randomized control trials have shown that higher blood eosinophil counts at the start of the study predict a greater response to ICS. CO...
Published in Clinica Chimica Acta; International Journal of Clinical Chemistry
Background In December 2019, coronavirus disease 2019 (COVID-19) was first found in Wuhan, China and soon was reported all around the world. Methods All confirmed cases with COVID-19 in Wenzhou from January 19 to February 20, 2020, were collected and analyzed. Of the 116 patients with COVID-19, 27 were diagnosed as severe cases. Among severe cases,...
Published in Asia Pacific Allergy
Background Even in subjects who are not sensitized to house dust mite (HDM), allergic symptoms can be clinically aggravated by exposure to dust. We previously reported that Dermatophagoides farinae ( Df ), an important HDM, or Der f 1, a major allergen of Df , induced the effector functions of eosinophils, which may be an important mechanism for HD...
