Fuschillo, Salvatore Molino, Antonio Stellato, Cristiana Motta, Andrea Maniscalco, Mauro
Published in
European journal of internal medicine
Disease phenotyping is a key step towards an increasingly personalized approach to chronic obstructive pulmonary disease (COPD), leading to a more precise assessment, treatment and definition of disease outcomes. The search for biomarkers able to guide the identification of COPD phenotypes are of great importance for both researchers and clinicians...
Paalme, Viiu Rump, Airi Mädo, Kati Teras, Marina Truumees, Birgit Aitai, Helen Ratas, Kristel Bourge, Mickael Chiang, Chi-Shiun Ghalali, Aram
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Published in
Frontiers in Immunology
Extracellular nucleotides are important mediators of cell activation and trigger multiple responses via membrane receptors known as purinergic receptors (P2). P2X receptors are ligand-gated ion channels, activated by extracellular ATP. P2X4 is one of the most sensitive purinergic receptors, that is typically expressed by neurons, microglia, and som...
Bosiljcic, Momir Cederberg, Rachel A. Hamilton, Melisa J. LePard, Nancy E. Harbourne, Bryant T. Collier, Jenna L. Halvorsen, Elizabeth C. Shi, Rocky Franks, S. Elizabeth Kim, Ada Y.
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Published in
Breast Cancer Research
BackgroundSolid tumors produce proteins that can induce the accumulation of bone marrow-derived cells in various tissues, and these cells can enhance metastatic tumor growth by several mechanisms. 4T1 murine mammary tumors are known to produce granulocyte colony-stimulating factor (G-CSF) and increase the numbers of immunosuppressive CD11b+Gr1+ mye...
Yancey, Steven W. Ortega, Hector G. Keene, Oliver N. Bradford, Eric S.
Published in
Allergy, Asthma & Clinical Immunology
Adolescents (12–17 years of age) with severe eosinophilic asthma experience frequent exacerbations and reduced lung function leading to poor health-related quality of life. Mepolizumab is approved for add-on maintenance therapy in patients with severe eosinophilic asthma ≥ 6 years of age in the EU and ≥ 12 years of age in other regions (including t...
Quijano-Gomero, E G Rodríguez-Zúñiga, M J M Sanz-Montero, M E Durand-Buse, D
Published in
Actas dermo-sifiliograficas
Primary recurrent cutaneous eosinophilic vasculitis is a rare condition characterized by pruritic, erythematous, purpuric plaques associated to edema. We compared and analyze the clinical, dermoscopic and histological features of the disease in 4 patients from our hospital and 13 patients published in the literature. Seventeen patients were include...
Youngblood, Bradford A. Brock, Emily C. Leung, John Falahati, Rustom Bryce, Paul J. Bright, Jessica Williams, Jason Shultz, Leonard D. Greiner, Dale L. Brehm, Michael A.
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Published in
International Archives of Allergy and Immunology
Introduction: Pathologic accumulation and activation of mast cells and eosinophils are implicated in allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is an inhibitory receptor selectively expressed on mast cells, eosinophils and, at a lower extent, basophils. When engaged with an antibody, Siglec-8 can i...
Vanharen, Marion Girard, Denis
It is becoming increasingly clear that nanoparticles (NPs) possess many potential applications in both clinical medicine and research. Potential utilization of NPs in nanomedicine for the treatment of respiratory diseases where eosinophils exert pathogenic roles is gaining increasing attention. Even though several NPs were found to possess pro-infl...
Sung, Yoon-Young Kim, Seung-Hyung Yuk, Heung Joo Yang, Won-Kyung Lee, Yun Mi Son, Eunjung Kim, Dong-Seon
Published in
Phytomedicine : international journal of phytotherapy and phytopharmacology
Siraitia grosvenorii fruits are used in traditional medicine to treat cough, sore throat, bronchitis, and asthma. This study aimed to investigate the anti-inflammatory and anti-asthmatic effects of S. grosvenorii residual extract (SGRE) on ovalbumin (OVA)-induced asthma in mice. Asthma was induced in BALB/c mice by systemic sensitization to OVA, fo...
Loktionov, Alexandre
Published in
World Journal of Gastroenterology
Eosinophils are currently regarded as versatile mobile cells controlling and regulating multiple biological pathways and responses in health and disease. These cells store in their specific granules numerous biologically active substances (cytotoxic cationic proteins, cytokines, growth factors, chemokines, enzymes) ready for rapid release. The huma...
Pignatti, Patrizia Visca, Dina Cherubino, Francesca Zampogna, Elisabetta Lucini, Etienne Saderi, Laura Sotgiu, Giovanni Spanevello, Antonio
Published in
Respiratory Research
IntroductionAirway eosinophilic inflammation is a characteristic of asthmatic patients and of a sub group of COPD subjects. Blood eosinophils are deemed as a good surrogate marker of sputum eosinophilic inflammation; however, controversial data have been published particularly in COPD. The aim of our study was to compare blood and sputum eosinophil...
