Kienzl, Melanie Hasenoehrl, Carina Valadez-Cosmes, Paulina Maitz, Kathrin Sarsembayeva, Arailym Sturm, Eva Heinemann, Akos Kargl, Julia Schicho, Rudolf
Published in
Oncoimmunology
In many types of cancer, presence of eosinophils in tumors correlate with an improved disease outcome. In line with this, activated eosinophils have been shown to reduce tumor growth in colorectal cancer (CRC). Interleukin (IL)-33 has recently emerged as a cytokine that is able to inhibit the development of tumors through eosinophils and other cell...
Knights, Alexander J. Vohralik, Emily J. Houweling, Peter J. Stout, Elizabeth S. Norton, Laura J. Alexopoulos, Stephanie J. Yik, Jinfen. J. Mat Jusoh, Hanapi Olzomer, Ellen M. Bell-Anderson, Kim S.
...
Published in
Nature Communications
Immune cells are important regulators of adipose tissue function, including adaptive thermogenesis. Here the authors show that mice with Krüppel-like factor 3 (KLF3) deficiency in bone marrow-derived cells have increased adipose tissue beiging which may at least in part be due to altered eosinophil paracrine signaling.
Choi, Youngwoo Sim, Soyoon Park, Hae-Sim
Published in
The Korean Journal of Internal Medicine
Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed. Nevertheless, 5% to 10% of adult asthmatic patients (called severe asthma) are in uncontrolled or partially controlled status despite int...
Tison, Katherine L. Patrawala, Meera Blaiss, Michael S.
Published in
Current Allergy and Asthma Reports
Purpose of ReviewThere has been an explosion of monoclonal antibodies in the treatment of severe uncontrolled adult asthma. Studies have now been published in severe pediatric asthma. There are numerous questions that need to be answered in determining whether these modalities are appropriate and safe in children.Recent FindingsThis is a narrative ...
Kotisalmi, Emma Hakulinen, Auli Mäkelä, Mika Toppila-Salmi, Sanna Kauppi, Paula
Published in
Asthma Research and Practice
BackgroundAnti-IgE (omalizumab) and anti-IL5/IL5R (reslizumab, mepolizumab and benralizumab) treatments are available for severe allergic and eosinophilic asthma. In these patients, studies have shown beneficial effects in oral corticosteroid use and exacerbations. The aim of this retrospective single-center study was to evaluate the effect of biol...
Siddiqui, Safia Jaiswal, Rohit Hashmi, Ghulam Sarwar
Published in
Journal of Oral and Maxillofacial Pathology : JOMFP
Background: Stromal response to cancer is usually characterized by intense lymphoplasmacytic infiltrate. However, recently, the attention has shifted to tumor-associated tissue eosinophils (TATE). Tumor-associated blood eosinophils (TABE) are rare in solid cancers; however, carcinoma of the head and neck shows its prevalence. Aim: The aim of the st...
Okuyama, Sho Yazu, Hiroyuki Ito, Yumi Minato, Hiroshi Fujishima, Hiroshi
Published in
The American Journal of Case Reports
Patient: Female, 55-year-old Final Diagnosis: Eosinophilic angiocentric fibrosis Symptoms: Lid swelling Medication: Topical eye drops Clinical Procedure: Resection of conjunctivas Specialty: Ophthalmology Objective: Rare disease Background: Eosinophilic angiocentric fibrosis (EAF) is an extremely rare disease with characteristic histopathological f...
Singh, Dave
Published in
Tuberculosis and Respiratory Diseases
Blood eosinophil counts have emerged as a chronic obstructive pulmonary disease (COPD) biomarker that predict the effects of inhaled corticosteroids (ICS) in clinical practice. Post-hoc and prospective analysis of randomized control trials have shown that higher blood eosinophil counts at the start of the study predict a greater response to ICS. CO...
Sun, Suyu Cai, Xuejiao Wang, Huaguo He, Guiqing Lin, Yin Lu, Bibi Chen, Chaoyue Pan, Yong Hu, Xingzhong
Published in
Clinica Chimica Acta; International Journal of Clinical Chemistry
Background In December 2019, coronavirus disease 2019 (COVID-19) was first found in Wuhan, China and soon was reported all around the world. Methods All confirmed cases with COVID-19 in Wenzhou from January 19 to February 20, 2020, were collected and analyzed. Of the 116 patients with COVID-19, 27 were diagnosed as severe cases. Among severe cases,...
Ueda, Yutaka Nakagome, Kazuyuki Kobayashi, Takehito Noguchi, Toru Soma, Tomoyuki Ohashi-Doi, Katsuyo Tokuyama, Kenichi Nagata, Makoto
Published in
Asia Pacific Allergy
Background Even in subjects who are not sensitized to house dust mite (HDM), allergic symptoms can be clinically aggravated by exposure to dust. We previously reported that Dermatophagoides farinae ( Df ), an important HDM, or Der f 1, a major allergen of Df , induced the effector functions of eosinophils, which may be an important mechanism for HD...