Oliveira, Bárbara M. Pinto, Ana Correia, Alexandra Ferreira, Paula G. Vilanova, Manuel Teixeira, Luzia
Published in
Scientific Reports
Immune cells resident in adipose tissue have important functions in local and systemic metabolic homeostasis. Nevertheless, these immune cell populations remain poorly characterized in bovines. Recently, we described diverse lymphocyte subpopulations in adipose tissue of Holstein-Friesian cows. Here, we aimed at characterising myeloid cell populati...
LEITE, Carine MAZZOLENI, Luiz Edmundo UCHOA, Diego de Mendonça CASTANHO, Juliana Araújo MAZZOLENI, Felipe SANDER, Guilherme Becker
ABSTRACT BACKGROUND: The role of Helicobacter pylori infection on eosinophilic infiltration in duodenal mucosa is poorly studied. An increase in the number of eosinophils in duodenum has been associated with functional dyspepsia. OBJECTIVE: To evaluate the influence of H. pylori infection on duodenal eosinophil count and the role of eosinophilic in...
Vega Villanueva, Karen L. Espinoza, Luis R.
Published in
Current Rheumatology Reports
Purpose of ReviewEosinophilic granulomatosis with polyangiitis (EGPA) represents a rare clinical entity, which is getting increasing attention and relevance in view of our better understanding and newer insights into its pathogenesis. Concomitantly better recognition and understanding of the immune pathophysiologic role of eosinophils provide a sol...
Bafadhel, Mona Singh, Dave Jenkins, Christine Peterson, Stefan Bengtsson, Thomas Wessman, Peter Fagerås, Malin
Published in
Respiratory Research
BackgroundClinically Important Deterioration (CID) is a novel composite measure to assess treatment effect in chronic obstructive pulmonary disease (COPD). We examined the performance and utility of CID in assessing the effect of inhaled corticosteroids (ICS) in COPD.MethodsThis post-hoc analysis of four budesonide/formoterol (BUD/FORM) studies com...
Harries, Timothy H. Rowland, Victoria Corrigan, Christopher J. Marshall, Iain J. McDonnell, Lucy Prasad, Vibhore Schofield, Peter Armstrong, David White, Patrick
Published in
Respiratory Research
BackgroundBlood eosinophil count has been proposed as a predictor of response to inhaled corticosteroid (ICS) in the prevention of acute exacerbations of COPD. An optimal threshold of blood eosinophil count for prescribing ICS has not been agreed. Doubt has been cast on the role by observational studies. The role of inhaled corticosteroids in this ...
LEITE, Carine MAZZOLENI, Luiz Edmundo UCHOA, Diego de Mendonça CASTANHO, Juliana Araújo MAZZOLENI, Felipe SANDER, Guilherme Becker
ABSTRACT BACKGROUND: The role of Helicobacter pylori infection on eosinophilic infiltration in duodenal mucosa is poorly studied. An increase in the number of eosinophils in duodenum has been associated with functional dyspepsia. OBJECTIVE: To evaluate the influence of H. pylori infection on duodenal eosinophil count and the role of eosinophilic in...
Yu, Bo Xu, Guoxing Liu, Xiaofan Yin, Wen Chen, Hao Sun, Baoqing
Published in
Allergy, Asthma & Clinical Immunology
BackgroundKimura’s disease (KD) is a rare chronic inflammatory disease with unknown etiology. It usually manifests as a painless soft tissue mass or subcutaneous nodule on one side of the patient’s head and/or neck and rarely affects multiple parts of the body. The disease is more common among young Asian males.Case presentationA 57-year-old Chines...
Ibrahim, H. O’Sullivan, R. Casey, D. Murphy, J. MacSharry, J. Plant, B. J. Murphy, D. M.
Published in
Respiratory Research
BackgroundIncreased numbers of blood and sputum eosinophils are associated with higher exacerbation frequency and increased asthma severity. In clinical trials, targeting Interleukin-5 has been shown to be a useful therapeutic strategy for patients with severe eosinophilic asthma.MethodsTwenty-six patients have been commenced on Reslizumab in our i...
Jackson, David J. Humbert, Marc Hirsch, Ian Newbold, Paul Garcia Gil, Esther
Published in
Advances in Therapy
Many patients with severe asthma have elevated numbers of eosinophils (a subset of white blood cells) and raised serum concentrations of immunoglobulin E (IgE; antibodies). Elevated eosinophil counts together with IgE concentrations are associated with more frequent asthma attacks. Benralizumab is a drug that almost completely depletes eosinophils ...
Mantani, Polyxeni T. Dunér, Pontus Ljungcrantz, Irena Nilsson, Jan Björkbacka, Harry Fredrikson, Gunilla Nordin
Published in
BMC Immunology
BackgroundExpansion of type 2 innate lymphoid cells (ILC2s) in hypercholesterolaemic mice protects against atherosclerosis while different ILC2 subsets have been described (natural, inflammatory) based on their suppression of tumorigenicity 2 (ST2) and killer-cell lectin like receptor G1 (KLRG1) expression. The aim of the current study is to charac...
