Gitto, Sarah B. Beardsley, Jordan M. Nakkina, Sai Preethi Oyer, Jeremiah L. Cline, Kathryn A. Litherland, Sally A. Copik, Alicja J. Khaled, Amr S. Fanaian, Na’im Arnoletti, J. Pablo
...
Published in
Cell Communication and Signaling
BackgroundWhile inflammation is associated with pancreatic cancer, the underlying mechanisms leading to cancer initiation are still being delineated. Eosinophils may promote or inhibit tumor growth, although the specific role in pancreatic cancer has yet to be determined. Eosinophil-supporting cytokine interleukin-5 and receptor are likely to have ...
Tison, Katherine L. Patrawala, Meera Blaiss, Michael S.
Published in
Current Allergy and Asthma Reports
Purpose of ReviewThere has been an explosion of monoclonal antibodies in the treatment of severe uncontrolled adult asthma. Studies have now been published in severe pediatric asthma. There are numerous questions that need to be answered in determining whether these modalities are appropriate and safe in children.Recent FindingsThis is a narrative ...
Kotisalmi, Emma Hakulinen, Auli Mäkelä, Mika Toppila-Salmi, Sanna Kauppi, Paula
Published in
Asthma Research and Practice
BackgroundAnti-IgE (omalizumab) and anti-IL5/IL5R (reslizumab, mepolizumab and benralizumab) treatments are available for severe allergic and eosinophilic asthma. In these patients, studies have shown beneficial effects in oral corticosteroid use and exacerbations. The aim of this retrospective single-center study was to evaluate the effect of biol...
Sun, Suyu Cai, Xuejiao Wang, Huaguo He, Guiqing Lin, Yin Lu, Bibi Chen, Chaoyue Pan, Yong Hu, Xingzhong
Published in
Clinica Chimica Acta; International Journal of Clinical Chemistry
Background In December 2019, coronavirus disease 2019 (COVID-19) was first found in Wuhan, China and soon was reported all around the world. Methods All confirmed cases with COVID-19 in Wenzhou from January 19 to February 20, 2020, were collected and analyzed. Of the 116 patients with COVID-19, 27 were diagnosed as severe cases. Among severe cases,...
Virchow, J. Christian Hickey, Lisa Du, Evelyn Garin, Margaret
Published in
Allergy, Asthma & Clinical Immunology
BackgroundA post hoc analysis of two randomized, placebo–controlled, Phase 3 trials of intravenous reslizumab, an anti-interleukin-5 (IL-5) biologic for severe eosinophilic asthma.MethodsRelationships between baseline blood eosinophil levels (EOS), forced expiratory volume in 1 s (FEV1) reversibility to β2-agonists and treatment outcomes were asses...
Li, Wei Gao, Ruihan Xin, Tong Gao, Peng
Published in
Respiratory Research
BackgroundInterleukin (IL)-35 is a newly discovered inhibitory cytokine which is produced by regulatory B and T lymphocytes and belongs to the IL-12 family. It plays a suppressive role in human inflammatory diseases; however, its role in asthma phenotypes is unclear. Our study focuses on the sputum IL-35 level in patients and investigates different...
Coppola, Angelo Flores, Krisstopher Richard De Filippis, Francesca
Published in
Respiratory medicine case reports
A 63 years - old woman affected by severe eosinophilic asthma associated with EGPA presented refractory respiratory symptoms, resistant to high dose oral corticosteroid treatment. A significant hyper-eosinophilia was present at the blood test, and the ACT score was steadily low, despite the maximal dose of inhalation therapy. The CT chest scan show...
Graeter, Stefanie Simon, Hans-Uwe von Gunten, Stephan
Published in
Pharmacological research
Granulocytes are key effector cells of the innate immune system that cause substantial by-stander tissue damage in a broad range of inflammatory disorders. Specific antibodies with the potential to regulate granulocyte survival are present in polyclonal intravenous immunoglobulin (IVIG) preparations and may contribute to the anti-inflammatory effec...
Backman, Helena Lindberg, Anne Hedman, Linnea Stridsman, Caroline Jansson, Sven-Arne Sandström, Thomas Lundbäck, Bo Rönmark, Eva
Background: The relationship between lung function decline and eosinophils and neutrophils has important therapeutic implications among asthmatics, but it has rarely been studied in large cohort studies. Objective: The aim is to study the relationship between blood eosinophils and neutrophils and FEV1 decline in a long-term follow-up of a populatio...
Tang, Bin Huang, Dan Wang, Jun Luo, Lin-lin Li, Qiu-gen
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background The 2018 Global Initiative for Chronic Obstructive Lung Disease Report reveals that the blood eosinophil count could forecast the risk of flare-ups. This study explored the correlations of blood eosinophils with fractional exhaled nitric oxide (FeNO) and pulmonary function parameters in acute exacerbation of chronic obstructive pulmonary...
