Hutchinson, AT Ramsland, PA Jones, DR Agostino, M Lund, ME Jennings, CV Bockhorni, V Yuriev, E Edmundson, AB Raison, RL
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Free κ L chains (FκLCs) are expressed on the surface of myeloma cells and are being assessed as a therapeutic target for the treatment of multiple myeloma. Despite its clinical potential, the mechanism by which FκLCs interact with membranes remains unresolved. In this study, we show that FκLCs associate with sphingomyelin on the plasma membrane of ...
Kusano, Masayuki Yasukawa, Kiyoshi Inouye, Kuniyo
We have previously indicated that three single mutations (Leu144-->Ser, Asp150-->Glu, and Ile168-->Ala) in the site-directed mutagenesis of thermolysin increase the activity and two single (Ser53-->Asp and Leu155-->Ala) and one triple (Gly8-->Cys/Asn60-->Cys/Ser65-->Pro) mutations increase the stability. In the present study, aiming to generate hig...
Mocumbi, AO Latif, N Yacoub, MH
Villavedra, M To, J Lemke, S Birch, D Crosbie, P Adams, M Broady, K Nowak, B Raison, RL Wallach, M
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Amoebic gill disease can be experimentally induced by the exposure of salmonids to Neoparamoeba spp. freshly isolated from infected fish, while cultured amoebae are non-infective. Results from our previous work suggested that one key difference between infectious and non-infectious Neoparamoeba were the highly glycosylated molecules in the glycocal...
Jones, R P Ridley, C Jowitt, T A Wang, M C Howard, M Bobola, N Wang, T Bishop, P N Kielty, C M Baldock, C
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PURPOSE: AMD has a complex etiology with environmental and genetic risk factors. Ten fibulin 5 sequence variants have been associated with AMD and two other fibulin 5 mutations cause autosomal-recessive cutis laxa. Fibulin 5 is a 52-kDa calcium-binding epidermal growth factor (cbEGF)-rich extracellular matrix protein that is essential for the forma...
w.c., ng wong, v. muller, b. rawlin, g. l.e., brown
10.1371/journal.pone.0013622 / PLoS ONE / 5 / 10 / e13622
Llirós, M. Gich, F. Plasencia, A. Auguet, J.-C. Darchambeau, François Casamayor, E. O. Descy, Jean-Pierre Borrego, C.
peer reviewed / Four stratified basins in Lake Kivu (Rwanda-Democratic Republic of theCongo) were sampled in March 2007 to investigate the abundance,distribution, and potential biogeochemical role of planktonic archaea. We used fluorescence in situ hybridization with catalyzed-reported deposition microscopic counts (CARD-FISH), denaturing gradient ...
Zhang, Z. Buitenhuis, J. Cukkemane, A. Brocker, M. Bott, M. Dhont, J. K. G.
There is increasing interest in the use of viruses as model systems for fundamental research and as templates for nanomaterials. In this work, the rodlike fd virus was subjected to chemical modifications targeting different solvent-exposed functional groups in order to tune its surface properties, especially reversing the surface charge from negati...
Birch, H. Alderwick, L. Appelmelk, B. Maaskant, J. Bhatt, A. Singh, A. Nigou, J. Eggeling, L. Geurtsen, J. Besra, G.
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Maintenance of cell-wall integrity in Mycobacterium tuberculosis is essential and is the target of several antitubercular drugs. For example, ethambutol targets arabinogalactan and lipoarabinomannan (LAM) biosynthesis through the inhibition of several arabinofuranosyltransferases. Apart from their role in cell-wall integrity, mycobacterial LAMs als...
Bruns, Alexander F Herbert, Shane P Odell, Adam F Jopling, Helen M Hooper, Nigel M Zachary, Ian C Walker, John H Ponnambalam, Sreenivasan
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Vascular endothelial growth factor A (VEGF-A)-induced signaling through VEGF receptor 2 (VEGFR2) regulates both physiological and pathological angiogenesis in mammals. However, the temporal and spatial mechanism underlying VEGFR2-mediated intracellular signaling is not clear. Here, we define a pathway for VEGFR2 trafficking and proteolysis that reg...