Cross prediction studies on spring barley
United Kingdom
Cross prediction studies on spring barley
SIGLE / Available from British Library Document Supply Centre- DSC:DXN053600 / BLDSC - British Library Document Supply Centre / GB / United Kingdom
Epistasis is a fundamental component of the genetic architecture of prolificacy in pigs.
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QTLs controlling fruit quality trait in tomato: stability of individual effect and epistasis
Both additivity and epistasis control the genetic variation for fruit quality traits in tomato
Published in Theoretical and Applied Genetics
The effect of a gene involved in the variation of a quantitative trait may change due to epistatic interactions with the overall genetic background or with other genes through digenic interactions. The classical populations used to map quantitative trait loci (QTL) are poorly efficient to detect epistasis. To assess the importance of epistasis in t...
A quasispecies approach to the evolution of sexual replication in unicellular organisms
This study develops a simplified model describing the evolutionary dynamics of a population composed of obligate sexually and asexually reproducing, unicellular organisms. The model assumes that the organisms have diploid genomes consisting of two chromosomes, and that the sexual organisms replicate by first dividing into haploid intermediates, whi...
A quasispecies approach to the evolution of sexual replication in unicellular organisms
This study develops a simplified model describing the evolutionary dynamics of a population composed of obligate sexually and asexually reproducing, unicellular organisms. The model assumes that the organisms have diploid genomes consisting of two chromosomes, and that the sexual organisms replicate by first dividing into haploid intermediates, whi...
QTL detection and estimation of the epistasis extent for chicken production and resistance to disease traits.
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Pathway and network-based analysis of genome-wide association studies in multiple sclerosis
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Published in Human Molecular Genetics
Genome-wide association studies (GWAS) testing several hundred thousand SNPs have been performed in multiple sclerosis (MS) and other complex diseases. Typically, the number of markers in which the evidence for association exceeds the genome-wide significance threshold is very small, and markers that do not exceed this threshold are generally negle...
A screening methodology based on Random Forests to improve the detection of gene-gene interactions.
Published in European journal of human genetics : EJHG
The search for susceptibility loci in gene-gene interactions imposes a methodological and computational challenge for statisticians because of the large dimensionality inherent to the modelling of gene-gene interactions or epistasis. In an era in which genome-wide scans have become relatively common, new powerful methods are required to handle the ...
