Published in Human Genetics
Large-scale epistasis studies can give new clues to system-level genetic mechanisms and a better understanding of the underlying biology of human complex disease traits. Though many novel methods have been proposed to carry out such studies, so far only a few of them have demonstrated replicable results. Here, we propose a minimal protocol for geno...
Published in Human Genetics
Over the past three decades, substantial developments have been made on how to infer the causal effect of an exposure on an outcome, using data from observational studies, with the randomized experiment as the golden standard. These developments have reshaped the paradigm of how to build statistical models, how to adjust for confounding, how to ass...
Published in BMC Medical Genetics
BackgroundThymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine, implicated in the development and progression of allergic diseases. Recent studies have demonstrated significantly increased expression and synthesis of TSLPin nasal mucosa of patients with allergic rhinitis (AR), compared with nonallergic control subjects. Also, ...
Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior
A sufficient cause interaction between two exposures signals the presence of individuals for whom the outcome would occur only under certain values of the two exposures. When the outcome is dichotomous and all exposures are categorical, then, under certain no confounding assumptions, empirical conditions for sufficient cause interactions can be con...
Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior
Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG), Brazil
Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG), Brazil
Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG), Brazil
