Dekker, Nienke Koeter, Maarten Van Den Brink, Wim
Published in
International journal of methods in psychiatric research
Cannabis use is more common in individuals with non-affective psychotic disorder and their siblings compared to healthy controls. As cannabis use is associated with a greater risk to develop psychotic disorder and an adverse outcome in those who already developed psychosis, it is important to know the role of craving in continued cannabis use and r...
Ma, Yao-Ying Henley, Sandy M Toll, Jeff Jentsch, James D Evans, Christopher J Levine, Michael S Cepeda, Carlos
To examine the mechanisms of drug relapse, we first established a model for cocaine IVSA (intravenous self-administration) in mice, and subsequently examined electrophysiological alterations of MSNs (medium-sized spiny neurons) in the NAc (nucleus accumbens) before and after acute application of cocaine in slices. Three groups were included: master...
Ma, Yao-Ying Henley, Sandy Toll, Jeff Jentsch, James Levine, Michael Cepeda, Carlos Evans, Christopher
To examine the mechanisms of drug relapse, we first established a model for cocaine IVSA (intravenous self-administration) in mice, and subsequently examined electrophysiological alterations of MSNs (medium-sized spiny neurons) in the NAc (nucleus accumbens) before and after acute application of cocaine in slices. Three groups were included: master...
Loweth, Jessica A Scheyer, Andrew F Milovanovic, Mike LaCrosse, Amber L Flores-Barrera, Eden Werner, Craig T Li, Xuan Ford, Kerstin A Le, Tuan Olive, M Foster
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Cue-induced cocaine craving is a major cause of relapse in abstinent addicts. In rats, cue-induced craving progressively intensifies (incubates) during withdrawal from extended-access cocaine self-administration. After ~1 month of withdrawal, incubated craving is mediated by Ca(2+)-permeable AMPA receptors (CP-AMPARs) that accumulate in the nucleus...
Leggio, GM Camillieri, G Platania, CBM Castorina, A Marrazzo, G Torrisi, SA Nona, CN D'Agata, V Nobrega, J Stark, H
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Mesolimbic dopamine (DA) controls drug- and alcohol-seeking behavior, but the role of specific DA receptor subtypes is unclear. We tested the hypothesis that D3R gene deletion or the D3R pharmacological blockade inhibits ethanol preference in mice. D3R-deficient mice (D 3R-/-) and their wild-type (WT) littermates, treated or not with the D3R antago...
Pelloux, Yann Murray, Jennifer Everitt, Barry J
Background: The availability of alternative reinforcement has been shown to reduce drug use, but it remains unclear whether it facilitates a reduction or cessation of drug seeking or taking. Objectives: We compared the effects of punishment of cocaine seeking or taking behaviour after brief or extended cocaine-taking histories when behavioural real...
Ostlund, Sean B LeBlanc, Kimberly H Kosheleff, Alisa R Wassum, Kate M Maidment, Nigel T
Drug addiction is marked by pathological drug seeking and intense drug craving, particularly in response to drug-related stimuli. Repeated psychostimulant administration is known to induce long-term alterations in mesolimbic dopamine (DA) signaling that are hypothesized to mediate this heightened sensitivity to environmental stimuli. However, there...
Gould, Adam T Sacramento, Arianne D Wroten, Melissa G Miller, Bailey W Jonquieres, Georg Klugmann, Matthias Ben‐Shahar, Osnat Szumlinski, Karen K
Withdrawal from a history of extended access to self-administered cocaine produces a time-dependent intensification of drug seeking, which might relate to a cocaine-induced imbalance in the relative expression of constitutively expressed Homer1 versus Homer2 isoforms within the ventromedial aspect of the prefrontal cortex (vmPFC). Thus, we employed...
Belin-Rauscent, Aude Fouyssac, Maxime Bonci, Antonello Belin, David
Drug addiction is a complex neuropsychiatric disorder that affects a subset of the individuals who take drugs. It is characterized by maladaptive drug-seeking habits that are maintained despite adverse consequences and intense drug craving. The pathophysiology and etiology of addiction is only partially understood despite extensive research because...
Aarde, Shawn M Miller, Michelle L Creehan, Kevin M Vandewater, Sophia A Taffe, Michael A
BackgroundExercise influences drug craving and consumption in humans and drug self-administration in laboratory animals, but the effects can be variable. Improved understanding of how exercise affects drug intake or craving would enhance applications of exercise programs to human drug users attempting cessation.MethodsRats were trained in the intra...
