Bioorganic chemistry : an international journal
Biotechnology and applied biochemistry
Current opinion in molecular therapeutics
Open access journal of medicinal and aromatic plants : OAJMAP
The open drug discovery journal
Tetrahedron letters
Journal of Ayurveda and integrative medicine : J-AIM
Human genomics
Drug design and delivery
Identification of Small Molecules That Suppress Ricin-Induced Stress-Activated Signaling Pathways
Ricin is a member of the ribosome-inactivating protein (RIP) family of plant and bacterial toxins. In this study we used a high-throughput, cell-based assay to screen more than 118,000 compounds from diverse chemical libraries for molecules that reduced ricin-induced cell death. We describe three compounds, PW66, PW69, and PW72 that at micromolar c...
