Vaghefinezhad, Neda Farsani, Samaneh Fazeli Gharaghani, Sajjad
Published in
Current drug discovery technologies
In the presented work we successfully discovered several novel NQO1 inducers using the computational approaches. The phytochemical sulforaphane (SFN) is a potent inducer of carcinogen detoxication enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1) through the Kelch-like erythroid cell-derived protein with CNC homology[ECH]-associated protein 1 (K...
Parameswaran, Preethi Ranjan, Nihar Flora, S J S
Published in
Medicinal chemistry (Shariqah (United Arab Emirates))
New chemical agents that could combat increasing antibiotic resistance are urgently needed. In this mini-review, an old but highly relevant RNA sequence which is crucial for the continuation of bacterial life-cycle is covered. Some of the most significant advances of the last decade in sensing and targeting the bacterial rRNA A-site: a well-validat...
Fontana, Alberto Iturrino, Laura Corens, David Crego, Antonio L
Published in
Journal of pharmaceutical and biomedical analysis
The need of a continuous productivity increases in medicinal chemistry laboratories of the pharmaceutical industry motivated the development, over the years, of new software solutions to enable Open-Access in many analytical techniques such as NMR or LC, among others, to characterize and assess the purity of new molecules. These approaches have bee...
Siddiqui, Farid A. Parkkola, Hanna Manoharan, Ganesh Babu Abankwa, Daniel
The protein-folding chaperone Hsp90 enables the maturation and stability of various oncogenic signaling proteins and is thus pursued as a cancer drug target. Folding in particular of protein kinases is assisted by the co-chaperone Cdc37. Several inhibitors against the Hsp90 ATP-binding site have been developed. However, they displayed significant t...
Milenkovic, Uros Ilg, Marcus M Cellek, Selim Albersen, Maarten
Published in
Sexual medicine reviews
Peyronie's disease (PD) is a debilitating affliction for the male population, causing severe curvatures to the erect penis and erectile dysfunction in about 50% of men. This deviation of the penis significantly impairs sexual intercourse and causes depression and strains in the relationship. As of today, medical treatment options are few and far be...
Dighe, SN Ekwudu, O Dua, K Chellappan, DK Katavic, PL Collet, TA
© 2019 Elsevier Masson SAS Dengue is the most important arthropod-borne viral disease of humans, with more than half of the global population living in at-risk areas. Despite the negative impact on public health, there are no antiviral therapies available, and the only licensed vaccine, Dengvaxia®, has been contraindicated in children below nine ye...
Canals, Meritxell Poole, Daniel P Veldhuis, Nicholas A Schmidt, Brian L Bunnett, Nigel W
Published in
Gastroenterology
G-protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins. In the gastrointestinal tract, GPCRs expressed by epithelial cells sense contents of the lumen, and GPCRs expressed by epithelial cells, myocytes, neurons, and immune cells participate in communication among cells. GPCRs control digestion, mediate digest...
Thomas, Sherine Collins, Patrick James, Rory Hennell Mendes, Vitor Charoensutthivarakul, Sitthivut Radoux, Chris Abell, Chris Coyne, Anthony Floto, Andres von Delft, Frank
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The Botnar Foundation (grant number: 6063), the Cystic Fibrosis Trust (Strategic Research Centre Awards 002, 010 & 201) and the Bill and Melinda Gates Foundation, Shorten-TB Award.
Lee, Alpha Yang, Qingyi Bassyouni, Asser Butler, Christopher R Hou, Xinjun Jenkinson, Stephen Price, David A
Clare, Rachel H Bardelle, Catherine Harper, Paul Hong, W David Börjesson, Ulf Johnston, Kelly L Collier, Matthew Myhill, Laura Cassidy, Andrew Plant, Darren
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