Deoxynivalenol (DON) is a type B trichothecene mycotoxin mainly produced by Fusarium genus. It is one of the most prevalent mycotoxins widely found in cereals and cereal-derived products. Cadmium is a component of earth’s crust and also a common environmental pollutant. It is a nonessential trace metal and toxic for humans and animals health. Altho...
Published in Toxicology Reports
Mycotoxin contamination of cereals is a significant health risk for humans and animals, particularly in developing countries. To gain insight into food safety related to agricultural practices, we assessed levels of mycotoxin contamination in 105 samples of food grains raised and stored for consumption by rural households in the post-conflict distr...
Published in AMB Express
Deoxynivalenol (DON) is one of the mycotoxins most frequently encountering in cereal-based foods throughout the world. Saccharomyces cerevisiae was used to alleviate porcine jejunal epithelia cell (IPEC-J2) injury induced by DON in this study. The results indicated that cell viability and proliferation rates were significantly decreased when DON co...
Disintegration of the intestine caused by deoxynivalenol (DON), which is a fungal metabolite found in cereal grain-based human and animal diets, triggers severe intestinal inflammatory disease. Hydrolyzed wheat gluten (HWG) can promote the development of intestine. Therefore, HWG was administered orally to male mice on 1-14 days, and DON was admini...
Published in Environmental pollution (Barking, Essex : 1987)
Deoxynivalenol (DON), a fungus-derived mycotoxin, also known as vomitoxin, is found in a wide range of cereal grains and grain-based food products. The biological toxicity of DON has been described in various species, but its toxicity and functional effects in mammary epithelial cells are unclear. In this study, we investigated the effect of DON on...
Published in BMB reports
Translation is a costly, but inevitable, cell maintenance process. To reduce unnecessary ATP consumption in cells, a fine-tuning mechanism is needed for both ribosome biogenesis and translation. Previous studies have suggested that the ribosome functions as a hub for many cellular signals such as ribotoxic stress response, mammalian target of rapam...
Published in Animal Nutrition
Weaning is a challenging stage of pig farming. Animals undergo environmental, social and dietary changes leading to weaning stress syndrome. In order to compensate for the detrimental effects of weaning stress, antibiotics and natural extracts are used as feed additives, sometimes without fully understanding the interactions between them or even wi...
Published in Biological trace element research
The combination of excess mycotoxin exposure and selenium deficiency has been widely considered as a cause of Kashin-Beck disease (KBD). The present study aimed to investigate the expression profiles of selenium-related genes in human chondrocytes after exposure to T-2 toxin and deoxynivalenol (DON) and to preliminarily identify the potential biolo...
Published in Environmental pollution (Barking, Essex : 1987)
Deoxynivalenol (DON) frequently detected in a wide range of foods and feeds, inducing cytotoxicity to animals and humans. To investigate the underlying mechanism of DON-induced apoptosis and inflammation in porcine small intestinal epithelium, intestinal porcine epithelial cells (IPEC-J2 cells) were chosen as objects, and were treated by different ...
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Deoxynivalenol (DON) is one of the most common mycotoxins produced by field fungi (especially Fusarium). Contamination of livestock feed is a significant risk factor, especially for pigs that are highly susceptible to the toxic effects of deoxynivalenol. In this study, validated ultra-high performance liquid chromatography (U-HPLC) combined with a ...
