Published in Toxicon: X
• Microbial DNA fragments were generated from a library of DON-tolerant microorganisms. • Fragments were screened in DON-sensitive yeast strains for their ability to modify or transport DON. • BLAST queries of one microbial fragment (4D) showed a high degree of similarity to an ABC transporter. • Transformants expressing a known efflux pump (PDR5) ...
Published in Journal of hazardous materials
Mycotoxins are among the compounds of most concern for human health because of their common presence in food and their proven toxicity for human health. Human biomonitoring (HBM) studies, foodstuff analysis and dietary surveys are usually used to assess human exposure, but they are costly and time-consuming. Wastewater-based epidemiology (WBE) can ...
The European Food Consumption Validation (EFCOVAL) project includes 600 men and women from Belgium, the Czech Republic, France, the Netherlands, and Norway, who had given serum and 24-hour urine samples, and completed 24-hour dietary recall (24-HDR) interviews. Consumption, according to 24-HDR, was matched against the European Food Safety Authority...
Fumonisins (FB1+FB2) and deoxynivalenol (DON) are mycotoxins produced by Fusarium species that might be present in maize and maize products. Knowledge on their occurrence in nixtamalized maize from Mexico together with an accompanying risk assessment are scarce, while nixtamalized maize is an important food in Mexico. This study presents the occurr...
Age-related differences in toxicokinetic processes of deoxynivalenol (DON) and deoxynivalenol-3-glucoside (DON3G) were studied. DON3G [55.7 mu g/kg bodyweight (BW)] and an equimolar dose of DON (36 mu g/kg BW) were administered to weaned piglets (4 weeks old) by single intravenous and oral administration in a double two-way cross-over design. Syste...
Deoxynivalenol is a common mycotoxin in grains such as wheat and corn. Contaminated food can seriously affect the health of humans and animals. Hence, to ensure the safety and quality of food at crucial segment, it is essential to manage the risk of Fusarium infection and deoxynivalenol (DON). Nowadays, countries around the world attach great impor...
Published in Frontiers in Pharmacology
Deoxynivalenol (DON) is a major fusarium toxin widely detected in cereal grains. The inadvertent exposure to this fungal secondary-metabolite gives rise to a myriad of adverse health effects including appetite loss, emesis, and suppression of the immune system. While most of the attention this mycotoxin has gained in the past four decades was relat...
Published in BMC Genomics
BackgroundFusarium graminearum is a destructive fungal pathogen of wheat, barley and other small grain cereals. During plant infection, the pathogen produces trichothecene mycotoxin deoxynivalenol (DON), which is harmful to human and livestock. FgGCN5 encodes a GCN5 acetyltransferase. The gene deletion mutant Fggcn5 failed to produce DON. We assume...
Published in Plant biotechnology journal
Taxonomically-restricted orphan genes play an important role in environmental adaptation, as recently demonstrated by the fact that the Pooideae-specific orphan TaFROG (Triticum aestivum Fusarium Resistance Orphan Gene) enhanced wheat resistance to the economically devastating Fusarium head blight (FHB) disease. Like most orphan genes, little is kn...
Published in Archives of animal nutrition
Deoxynivalenol (DON), a mycotoxin synthesised by the Fusarium, is known to affect the growth of pigs. This effect can be attenuated with sodium meta-bisulphite (SBS). The aim of this study was to evaluate the effect of SBS with antioxidant blend on nutrient digestibility in pigs fed a diet contaminated naturally with DON. Six crossbred castrated pi...
