Ströhle, Mathias Rugg, Christopher Schmid, Stefan Fries, Dietmar Oswald, Elgar
Published in
Trauma case reports
Dabigatran is an oral anticoagulant directly acting as thrombin inhibitor. The monoclonal antibody idarucizumab was developed to reverse its anticoagulatory effects after application of a standardized dose. Following administration, dabigatran plasma level rebounds have been reported but its consequences are not fully understood. We report a case o...
Oberladstätter, Daniel Voelckel, Wolfgang Bruckbauer, Martin Zipperle, Johannes Grottke, Oliver Ziegler, Bernhard Schöchl, Herbert
Published in
European journal of trauma and emergency surgery : official publication of the European Trauma Society
Trauma care providers are facing an increasing number of elderly patients on direct oral anticoagulants prior to injury. For dabigatran etexilate (DAB), the specific antagonist idarucizumab (IDA) has been approved since 2015 as a reversal agent. However, only limited data regarding the use of IDA in trauma patients are available. We performed a ret...
Groene, Philipp Wagner, Daniela Kammerer, Tobias Kellert, Lars Giebl, Andreas Massberg, Steffen Schäfer, Simon Thomas
Published in
Thrombosis Journal
BackgroundDetermination of anticoagulant therapy is of pronounced interest in emergency situations. However, routine tests do not provide sufficient insight. This study was performed to investigate the impact of anticoagulants on the results of viscoelastometric assays using the ClotPro device.MethodsThis prospective, observational study was conduc...
Wang, Tong Liu, Qian Long, Wan-Jun Chen, An-Qi Wu, Hai-Long Yu, Ru-Qin
Published in
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
In this paper, a simple, rapid, low-cost and potential method was established for the simultaneous quantitative analysis of dabigatran etexilate (DABE) and dabigatran (DAB) in spiked biological fluids. It combined excitation-emission matrix fluorescence (EEMF) with different second-order calibration methods, including the self-weighted alternating ...
Vinding, Naja Emborg Staerk, Laila Gislason, Gunnar Hilmar Torp-Pedersen, Christian Bonde, Anders Nissen Rørth, Rasmus Lee, Christina J-Y Olesen, Jonas Bjerring Køber, Lars Fosbøl, Emil Loldrup
...
Published in
European heart journal. Cardiovascular pharmacotherapy
In atrial fibrillation (AF) patients 150 mg b.i.d. dabigatran is the standard dose, yet guidelines recommend 110 mg b.i.d. when bleeding risk is high. It is unknown to which extend these recommendations are followed in patients switching from vitamin K antagonist (VKA) to dabigatran. The aim of this study was to investigate if AF patients are switc...
Hwang, Jongmin Lee, So-Ryoung Park, Hyoung-Seob Lee, Young Soo Ahn, Jin Hee Choi, Jong-Il Shin, Dong Gu Kim, Dae-Kyeong Park, Jong Sung Hwang, Ki Won
...
Published in
International journal of cardiology
Dabigatran-induced gastrointestinal discomfort (DGID) is an important factor influencing the adherence to dabigatran. We investigated the incidence and risk factors of DGID and its impact on the adherence and persistence to dabigatran. We prospectively enrolled the patients prescribed with dabigatran in 10 tertiary hospitals of the South Korea. The...
Tomida, Hideomi Yoshio, Toshiyuki Igarashi, Kimihiro Morita, Yoshinori Oda, Ichiro Inoue, Takuya Hikichi, Takuto Sumiyoshi, Tetsuya Doyama, Hisashi Tsuji, Yosuke
...
Published in
Gastric Cancer
Background and aimsDelayed bleeding after gastric endoscopic submucosal dissection (ESD) in patients receiving anticoagulants remains an unpreventable adverse event. Although direct-acting oral anticoagulants (DOACs) have superior efficacy in preventing thromboembolism, their effects on the occurrence of delayed bleeding remain unclear. This study ...
Narina, Deepthi
Newer oral anticoagulants (NOAs) such as dabigatran etexilate, rivaroxaban, edoxaban, and apixaban are widely used these days as an alternative to warfarin for anticoagulation. Surgical procedures such as extraction are common during dental treatments and are often associated with bleeding. Hence, when treating patients taking anticoagulants clinic...
Paar, Vera Jirak, Peter Gruber, Susanne Prodinger, Christine Cadamuro, Janne Wernly, Bernhard Motloch, Lukas J Haschke-Becher, Elisabeth Hoppe, Uta C Lichtenauer, Michael
...
Published in
Life sciences
Blood coagulation is one of the most important host-defending mechanisms in vivo by maintaining the blood pressure after injury. However, besides maintaining homeostasis, blood coagulation and the contributing factors are directly linked to pathological conditions, such as thromboembolism and inflammation, leading to cardiovascular diseases, among ...
Toyoda, Kazunori Uchiyama, Shinichiro Hagihara, Yasushi Kuwashiro, Takahiro Mori, Takahisa Kamiyama, Kenji Urano, Yasuhisa Taniguchi, Atsushi Nozaki, Kenma Cronin, Lisa
...
Published in
Circulation journal : official journal of the Japanese Circulation Society
The international Randomized, Double-Blind, Evaluation in Secondary Stroke Prevention Comparing the EfficaCy and Safety of the Oral Thrombin Inhibitor Dabigatran Etexilate versus Acetylsalicylic Acid in Patients with Embolic Stroke of Undetermined Source (RE-SPECT ESUS) trial did not demonstrate superiority of dabigatran over aspirin for reduction ...
