Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia
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Canadian Institutes of Health Research[GMH79042]
Canadian Institutes of Health Research[GMH79042]
Canadian Institutes of Health Research[GMH79042]
Although telomere biology was revealed to play an important role in several hematopoietic disorders, its impact on the age-dependent dynamics of regular hematopoiesis is poorly understood. In vitro results suggest that particularly the erythropoietic capacity might be limited by critically short telomere length (TL). However, it remains unclear whe...