Hsieh, Shulan Yang, Meng-Heng
Published in
Frontiers in Aging Neuroscience
Cognitive aging, especially cognitive control, and processing speed aging have been well-documented in the literature. Most of the evidence was reported based on cross-sectional data, in which inter-individual age effects were shown. However, there have been some studies pointing out the possibility of overlooking intra-individual changes in cognit...
Zamani, Akram Walker, Adam K. Rollo, Ben Ayers, Katie L. Farah, Raysha O'Brien, Terence J. Wright, David K.
Published in
NeuroImage : Clinical
Amyotrophic lateral sclerosis (ALS) is characterized by transactive response DNA-binding protein 43 (TDP-43) pathology, progressive loss of motor neurons and muscle dysfunction. Symptom onset can be insidious and diagnosis challenging. Conventional neuroimaging is used to exclude ALS mimics, however more advanced neuroimaging techniques may facilit...
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(1) Background: Glioblastoma multiforme (GBM) shows complex mechanisms of spreading of the tumor cells, up to remote areas, and little is still known of these mechanisms, thus we focused on MRI abnormalities observable in the tumor and the brain adjacent to the lesion, up to the contralateral hemisphere, with a special interest on tensor diffusion ...
Lee, Wha Jin Brown, Jesse A Kim, Hye Ryun La Joie, Renaud Cho, Hanna Lyoo, Chul Hyoung Rabinovici, Gil D Seong, Joon-Kyung Seeley, William W
Published in
Neuron
Amyloid-beta and tau are key molecules in the pathogenesis of Alzheimer's disease, but it remains unclear how these proteins interact to promote disease. Here, by combining cross-sectional and longitudinal molecular imaging and network connectivity analyses in living humans, we identified two amyloid-beta/tau interactions associated with the onset ...
Sihvonen, Aleksi J Siponkoski, Sini-Tuuli Martínez-Molina, Noelia Laitinen, Sari Holma, Milla Ahlfors, Mirja Kuusela, Linda Pekkola, Johanna Koskinen, Sanna Särkämö, Teppo
...
Published in
Journal of clinical medicine
Traumatic brain injury (TBI) is a common and devastating neurological condition, associated often with poor functional outcome and deficits in executive function. Due to the neuropathology of TBI, neuroimaging plays a crucial role in its assessment, and while diffusion MRI has been proposed as a sensitive biomarker, longitudinal studies evaluating ...
Li, Xin Salami, Alireza Avelar-Pereira, Bárbara Bäckman, Lars Persson, Jonas
Working memory, a core function underlying many higher-level cognitive processes, requires cooperation of multiple brain regions. White matter refers to myelinated axons, which are critical to interregional brain communication. Past studies on the association between white-matter integrity and working memory have yielded mixed findings. Using voxel...
Chen, Senlin Wang, Ying Wu, Xianyong Chang, Jianchao Jin, Weiming Li, Wei Song, Peiwen Wu, Yuanyuan Zhu, Jiajia Qian, Yinfeng
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Published in
Frontiers in Aging Neuroscience
Degenerative cervical myelopathy is a progressive neurodegenerative disease, that has become increasingly prevalent in the aging population worldwide. The current study determined the factors affecting degeneration in the sensorimotor tract with degenerative cervical myelopathy and its relationship with brain structure. We divided patients into hyp...
Hoare, Jacqueline Stein, Dan J Heany, Sarah J Fouche, Jean-Paul Phillips, Nicole Er, Sebnem Myer, Landon Zar, Heather J Horvath, Steve Levine, Andrew J
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Published in
Journal of neurovirology
We recently demonstrated that adolescents perinatally infected with HIV-1 (PHIV+) have accelerated aging as measured by a highly accurate epigenetic biomarker of aging known as the epigenetic clock. However, whether epigenetic age acceleration in PHIV+ impacts brain development at the macro- and microstructural levels of brain anatomy has not been ...
Elliott, Blake L D'Ardenne, Kimberlee Mukherjee, Prerona Schweitzer, Julie B McClure, Samuel M
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
Impulsivity is a defining characteristic of attention-deficit/hyperactivity disorder (ADHD), which has been associated with substance use disorders, higher accident rates, and lower educational and occupational outcomes. The meso- and nigrostriatal pathways of the dopamine system are hypothesized to be functionally heterogeneous, supporting diverse...
Langley, Jason Hussain, Sana Huddleston, Daniel E Bennett, Ilana J Hu, Xiaoping P
Published in
Brain connectivity
Introduction: Locus coeruleus (LC) is the primary source of norepinephrine to the brain and its efferent projections innervate many brain regions, including the thalamus. The LC degrades with normal aging, but not much is known regarding whether its structural connectivity evolves with age or predicts aspects of cognition. Methods: Here, we use hig...
