Pei, Bing Zhao, Guodong Geng, Zhixin Wang, Yue Wang, Menglin Wang, Xiaomei Xiong, Shangmin Zheng, Minxue
Published in
Frontiers in Genetics
Background: Esophageal cancer (EC) is a leading cause of cancer-related deaths in China, with the 5-year survival rate reaching less than 30%, because most cases were diagnosed and treated at the advanced stage. However, there is still a lack of low-cost, efficient, and accurate non-invasive methods for the early detection of EC at present. Methods...
Cai, Ruijie Lv, Runyu Shi, Xin'e Yang, Gongshe Jin, Jianjun
Published in
International journal of molecular sciences
CRISPR/Cas9-mediated cleavage of DNA, which depends on the endonuclease activity of Cas9, has been widely used for gene editing due to its excellent programmability and specificity. However, the changes to the DNA sequence that are mediated by CRISPR/Cas9 affect the structures and stability of the genome, which may affect the accuracy of results. M...
Gu, Zefeng Yang, Jingmiao Lu, Jinzhao Yang, Min Deng, Yuewen Jiao, Yu
Published in
Frontiers in Immunology
Introduction In the pearl culture industry, a major challenge is the overactive immunological response in pearl oysters resulting from allotransplantation, leading to shell-bead rejection and death. To better understand the molecular mechanisms of postoperative recovery and the regulatory role of DNA methylation in gene expression, we analyzed the ...
Kaur, Lovejeet Sundrani, Deepali Dave, Kinjal Randhir, Karuna Mehendale, Savita Bayyana, Swati Kalyanaraman, Kumaran Chandak, Giriraj R Joshi, Sadhana
Published in
Molecular and cellular biochemistry
Preeclampsia is a placental vascular pathology and hypoxia is known to influence placental angiogenesis. Hypoxia Inducible Factors (HIF1α and HIF3α) mediate the response to cellular oxygen concentration and bind to hypoxia response element of target genes. However the mechanism regulating above activity is not well-understood. We investigated if pl...
Lin, Zeshan Lu, Yan Yu, Guoliang Teng, Huajing Wang, Bao Yang, Yajun Li, Qinglan Sun, Zhongsheng Xu, Shuhua Wang, Wen
...
Published in
Science China. Life sciences
DNA methylation (DNAm) is one of the major epigenetic mechanisms in humans and is important in diverse cellular processes. The variation of DNAm in the human population is related to both genetic and environmental factors. However, the DNAm profiles have not been investigated in the Chinese population of diverse ethnicities. Here, we performed doub...
Kulkarni, Prakash G Balasubramanian, Nagalakshmi Manjrekar, Ritika Banerjee, Tanushree Sakharkar, Amul
Published in
Cellular and molecular neurobiology
Repeated mild traumatic brain injuries (rMTBI) affect mitochondrial homeostasis in the brain. However, mechanisms of long-lasting neurobehavioral effects of rMTBI are largely unknown. Mitofusin 2 (Mfn2) is a critical component of tethering complexes in mitochondria-associated membranes (MAMs) and thereby plays a pivotal role in mitochondrial functi...
Jokai, Matyas Torma, Ferenc McGreevy, Kristen M Koltai, Erika Bori, Zoltan Babszki, Gergely Bakonyi, Peter Gombos, Zoltan Gyorgy, Bernadett Aczel, Dora
...
Published in
GeroScience
DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33-88 with a wide range of physical fitness (including athletes with long-term training history). Hig...
Jian, Jimo Yuan, Chenglu Ji, Chunyan Hao, Hongyuan Lu, Fei
Published in
Clinical and experimental medicine
Acute myeloid leukemia (AML) is a malignancy of the stem cell precursors of the myeloid lineage. DNA methylation is an important DNA modification that regulates gene expression. Investigating AML heterogeneity based on DNA methylation could be clinically informative for improving clinical diagnosis and prognosis. The AML subtypes based on DNA methy...
Laine, Veronika N Sepers, Bernice Lindner, Melanie Gawehns, Fleur Ruuskanen, Suvi van Oers, Kees
Published in
Molecular ecology resources
The field of molecular biology is advancing fast with new powerful technologies, sequencing methods and analysis software being developed constantly. Commonly used tools originally developed for research on humans and model species are now regularly used in ecological and evolutionary research. There is also a growing interest in the causes and con...
Soliai, Marcus M Kato, Atsushi Naughton, Katherine A Norton, James E Klinger, Aiko I Kern, Robert C Tan, Bruce K Nicolae, Dan L Schleimer, Robert P Ober, Carole
...
Published in
Allergy
Viruses may drive immune mechanisms responsible for chronic rhinosinusitis with nasal polyposis (CRSwNP), but little is known about the underlying molecular mechanisms. To identify epigenetic and transcriptional responses to a common upper respiratory pathogen, rhinovirus (RV), that are specific to patients with CRSwNP using a primary sinonasal epi...
