Pollard, Chad Aston, Kenneth Emery, Benjamin R. Hill, Jonathon Jenkins, Timothy
Published in
Frontiers in Neurology
Neurodegenerative diseases, such as Alzheimer’s disease (AD), pose significant challenges in early diagnosis, leading to irreversible brain damage and cognitive decline. In this study, we present a novel diagnostic approach that utilizes whole molecule analysis of neuron-derived cell-free DNA (cfDNA) as a biomarker for early detection of neurodegen...
Wallace, LaShanale Obeng, Esther A.
Published in
Frontiers in Molecular Biosciences
Hematopoiesis is an essential process for organismal development and homeostasis. Epigenetic regulation of gene expression is critical for stem cell self-renewal and differentiation in normal hematopoiesis. Increasing evidence shows that disrupting the balance between self-renewal and cell fate decisions can give rise to hematological diseases such...
Zhang, Yu Huang, Dongmei Miao, Ying
Published in
Frontiers in Plant Science
Plant senescence is the last stage of plant development and a type of programmed cell death, occurring at a predictable time and cell. It involves the functional conversion from nutrient assimilation to nutrient remobilization, which substantially impacts plant architecture and plant biomass, crop quality, and horticultural ornamental traits. In pa...
Kocher, Kristen Bhattacharya, Surajit Niforatos-Andescavage, Nickie Almalvez, Miguel Henderson, Diedtra Limperopoulos, Catherine Délot, Emmanuèle Vilain, Eric
BACKGROUND: During gestation, stressors to the fetus, including viral exposure or maternal psychological distress, can fundamentally alter the neonatal epigenome, and may be associated with long-term impaired developmental outcomes. The impact of in utero exposure to the COVID-19 pandemic on the newborn epigenome has yet to be described. METHODS: T...
Sarnowski, Chloé Huan, Tianxiao Ma, Yiyi Joehanes, Roby Beiser, Alexa Heard-Costa, Nancy Levy, Daniel Lin, Honghuang Liu, Ching-Ti Liu, Chunyu
...
BACKGROUND: Insulin resistance (IR) is a major risk factor for Alzheimers disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signatures of IR associated with AD, thus improving our understanding of the biological and regulatory mechanisms linking IR and AD. MET...
Albinati, Leone Bianchi, Agostina Beekman, Renée
Published in
Frontiers in Molecular Biosciences
Gupta, Shruti Kanwar, Shamsher Singh
Published in
Exploration of Targeted Anti-tumor Therapy
Renal cell carcinoma (RCC) is one of the most life-threatening urinary malignancies displaying poor response to radiotherapy and chemotherapy. Although in the recent past there have been tremendous advancements in using targeted therapies for RCC, despite that it remains the most lethal urogenital cancer with a 5-year survival rate of roughly 76%. ...
Tutt, Desmond A. R. Guven-Ates, Gizem Kwong, Wing Yee Simmons, Rob Sang, Fei Silvestri, Giuseppe Canedo-Ribeiro, Carla Handyside, Alan H. Labrecque, Remi Sirard, Marc-André
...
Published in
Frontiers in Endocrinology
Background In vitro maturation (IVM) of germinal vesicle intact oocytes prior to in vitro fertilization (IVF) is practiced widely in animals. In human assisted reproduction it is generally reserved for fertility preservation or where ovarian stimulation is contraindicated. Standard practice incorporates complex proteins (CP), in the form of serum a...
Bergsten, Emma Mestivier, Denis Donnadieu, Francoise Pedron, Thierry Barau, Caroline Meda, Landry Tsoumtsa Mettouchi, Amel Lemichez, Emmanuel Gorgette, Olivier Chamaillard, Mathias
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Recently, an intestinal dysbiotic microbiota with enrichment in oral cavity bacteria has been described in colorectal cancer (CRC) patients. Here, we characterize and investigate one of these oral pathobionts, the Gram-positive anaerobic coccus Parvimonas micra. We identified two phylotypes (A and B) exhibiting different phenotypes and adhesion cap...
Deardorff, Julianna Cardenas, Andres Bozack, Anne Veazie, Stephanie Nwanaji-Enwerem, Jamaji Van Der Laan, Lars Riddell, Corinne Eskenazi, Brenda Holland, Nina Collender, Philip
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BACKGROUND: Adverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may also have intergenerational health effects by which parental ACEs are associated with mental and physical health of children. Epigenetic programming may be one mechanism linking parental ACEs to child health. This stu...
