Can DNA Methylation Predict the Lipid Response to Dietary Intervention? There's a Fat Chance.
Published in The Journal of clinical endocrinology and metabolism
Nucleoside-Driven Specificity of DNA Methyltransferase.
Published in Chembiochem : a European journal of chemical biology
We have studied the adenosine binding specificities of two bacterial DNA methyltransferases, Taq methyltransferase (M.TaqI), and HhaI methyltransferase (M.HhaI). While they have similar cofactor binding pocket interactions, experimental data showed different specificity for novel S-nucleobase-l-methionine cofactors (SNMs; N=guanosyl, cytidyl, uridy...
The relationship between miR-21, DNA methylation, and bisphenol a in bovine COCs and granulosa cells
Published in Frontiers in Cell and Developmental Biology
Introduction: miR-21 is a critical microRNA for the regulation of various processes in oocytes and granulosa cells. It is involved in the modulation of apoptosis and can influence other epigenetic mechanisms. Among these mechanisms, DNA methylation holds significant importance, particularly during female gametogenesis. Evidence has demonstrated tha...
Methylome changes in Lolium perenne associated with long-term colonisation by the endophytic fungus Epichloë sp. LpTG-3 ...
Published in Frontiers in Plant Science
Plant epigenetics and chromatin dynamics - EPIPLANT 2021-2022
Published in Frontiers in Plant Science
Comprehensive analysis of PRPF19 immune infiltrates, DNA methylation, senescence-associated secretory phenotype and ceRN...
Published in Frontiers in Immunology
Background Pre-mRNA processing factor 19 (PRPF19) is an E3 ligase that plays a crucial role in repairing tumor-damaged cells and promoting cell survival. However, the predictive value and biological function of PRPF19 in bladder urothelial carcinoma (BLCA) require further investigation. Methods In this study, we utilized transcriptomic data and bla...
Characterization of H3K9me3 and DNA methylation co-marked CpG-rich regions during mouse development.
Published in BMC genomics
H3K9me3 and DNA methylation co-marked CpG-rich regions (CHMs) are functionally important in mouse pre-implantation embryos, but their characteristics in other biological processes are still largely unknown. In this study, we performed a comprehensive analysis to characterize CHMs during 6 mouse developmental processes, identifying over 2,600 CHMs e...
Integrative transcriptome analysis reveals alternative polyadenylation potentially contributes to GCRV early infection
Published in Frontiers in Microbiology
Introduction Grass carp reovirus (GCRV), a member of the Aquareovirus genus in the Reoviridae family, is considered to be the most pathogenic aquareovirus. Productive viral infection requires extensive interactions between viruses and host cells. However, the molecular mechanisms underlying GCRV early infection remains elusive. Methods In this stud...
F-box protein 43 promoter methylation as a novel biomarker for hepatitis B virus-associated hepatocellular carcinoma
Published in Frontiers in Microbiology
Background Hepatocellular carcinoma (HCC) has a high prevalence and poor prognosis worldwide. Therefore, it is urgent to find effective and timely diagnostic markers. The objective of this study was to evaluate the diagnostic value of F-box protein 43 promoter methylation in peripheral blood mononuclear cells (PBMCs) for HCC. Method A total of 247 ...
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivit...
Published in Journal of periodontology
The aim of this study was to investigate the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation of DNA, and between these same SNPs and tooth loss, high-sensitivity C-reactive protein (hs-CRP), and glycated hemoglobin (HbA1c) levels. We included participants with periodontal ...
