Leung, Christelle Grulois, Daphné Chevin, Luis-Miguel
Published in
Molecular ecology
Phenotypic plasticity, the ability of a given genotype to produce alternative phenotypes in response to its environment of development, is an important mechanism for coping with variable environments. While the mechanisms underlying phenotypic plasticity are diverse, their relative contributions need to be investigated quantitatively to better unde...
Beach, Steven R H Ong, Mei Ling Lei, Man-Kit Carter, Sierra E Simons, Ronald L Gibbons, Frederick X Philibert, Robert A
Published in
Epigenetics
Methylation of FKBP5 is involved in the regulation of the stress response and is influenced by early stress exposure. Two CpG sites, cg20813374 and cg00130530, have been identified as potential reporters of early stress. We examined whether FKBP5 methylation was associated with accelerated DNA methylation ageing and indirectly predicted poorer card...
Sivanesan, Iyyakkannu Nayeem, Safia Venkidasamy, Baskar Kuppuraj, Sree Preethy Rn, Chithraanjane Samynathan, Ramkumar
Published in
Biologia futura
Somatic embryogenesis (SE) is a mode of stimulated plant cell totipotency wherein embryos form without fertilization either through somatic or vegetative origins. SE has two main phases: induction and a developmental phase. The induction phase comprises cell proliferation and dedifferentiation, whereas the developmental phase involves the different...
Majumder, Shounak Taylor, William R Foote, Patrick H Gysbers, Brianna J Cao, Xiaoming Mahoney, Douglas W Burger, Kelli N Doering, Karen A Graham, Rondell P Couch, Fergus J
...
Published in
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
High-risk individuals (HRIs) with familial and genetic predisposition to pancreatic ductal adenocarcinoma (PDAC) are eligible for screening. There is no accurate biomarker for detecting early-stage PDAC. We previously demonstrated that a panel of methylated DNA markers (MDMs) accurately detect sporadic PDAC. In this study we compared the distributi...
Yu, Ming Moinova, Helen R Willbanks, Amber Cannon, Victoria K Wang, Ting Carter, Kelly Kaz, Andrew Reddi, Deepti Inadomi, John Luebeck, Georg
...
Published in
Clinical cancer research : an official journal of the American Association for Cancer Research
Current endoscopy-based screening and surveillance programs have not been proven effective at decreasing esophageal adenocarcinoma (EAC) mortality, creating an unmet need for effective molecular tests for early detection of this highly lethal cancer. We conducted a genome-wide methylation screen to identify novel methylation markers that distinguis...
Laajala, Essi Kalim, Ubaid Ullah Grönroos, Toni Rasool, Omid Halla-Aho, Viivi Konki, Mikko Kattelus, Roosa Mykkänen, Juha Nurmio, Mirja Vähä-Mäkilä, Mari
...
Published in
Diabetologia
Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes. Reduced representation bisulphite sequencing (RRBS) analysis was performed on umbilical cord blood ...
Seligman, Benjamin J Berry, Sarah D Lipsitz, Lewis A Travison, Thomas G Kiel, Douglas P
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Age-associated changes in DNA methylation have been implicated as 1 mechanism to explain the development of frailty; however, previous cross-sectional studies of epigenetic age acceleration (eAA) and frailty have had inconsistent findings. Few longitudinal studies have considered the association of eAA with change in frailty. We sought to determine...
Přibylová, Adéla Fischer, Lukáš Pyott, Douglas E Bassett, Andrew Molnar, Attila
Published in
The New phytologist
The impact of epigenetic modifications on the efficacy of CRISPR/Cas9-mediated double-stranded DNA breaks and subsequent DNA repair is poorly understood, especially in plants. In this study, we investigated the effect of the level of cytosine methylation on the outcome of CRISPR/Cas9-induced mutations at multiple Cas9 target sites in Nicotiana bent...
Alfimova, M. Kondratyev, N. Golov, A. Gabaeva, M. Plakunova, V. Golimbet, V.
Published in
European Psychiatry
Introduction Stress caused by childhood adversity (CA) is known to contribute to schizophrenia risk and symptoms. Its effects might be mediated by epigenetic mechanisms, specifically DNA methylation (meDNA) within relevant genes, and predominantly influence the hippocampus and prefrontal cortex (PFC). CYP17A1 is a candidate, as it situates within a...
Zhu, Na Geng, Xilin Ji, Xiaotong Gao, Rui Li, Dan Yue, Huifeng Li, Guangke Sang, Nan
Published in
Environmental research
Placental senescence is a normal physiological process of placenta, while premature placental senescence has been confirmed to be associated with some adverse pregnancy complications. Epidemiological studies indicate that NO2 exposure can aggravate placental senescence which is represented by fibrosis and abnormal telomere homeostasis, etc. In this...
