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Vanbillemont, Brecht Lammens, Joris Goethals, Wannes Vervaet, Chris Boone, Matthieu N. De Beer, Thomas
Published in
Pharmaceutics
Maintaining chemical and physical stability of the product during freeze-drying is important but challenging. In addition, freeze-drying is typically associated with long process times. Therefore, mechanistic models have been developed to maximize drying efficiency without altering the chemical or physical stability of the product. Dried product ma...
Rentería Gámiz, Gabriela Van Bockstal, Pieter-Jan De Meester, Steven De Beer, Thomas Corver, Jos Dewulf, Jo
Whilst freeze drying is known by its high energy requirements, few studies have been conducted assessing the efficiency of freeze dryers, specially related pharmaceuticals. A quantitative analysis is conducted on a batch freeze dryer used for biopharmaceuticals, aiming to know the process efficiency and to identify the components having the highest...
Van Bockstal, Pieter-Jan Mortier, Séverine Thérèse F C De Meyer, Laurens Corver, Jos Vervaet, Chris Nopens, Ingmar De Beer, Thomas
Published in
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Conventional pharmaceutical freeze-drying is an inefficient and expensive batch-wise process, associated with several disadvantages leading to an uncontrolled end product variability. The proposed continuous alternative, based on spinning the vials during freezing and on optimal energy supply during drying, strongly increases process efficiency and...
Van Bockstal, Pieter-Jan De Meyer, Laurens Corver, Jos Vervaet, Chris De Beer, Thomas
Published in
Journal of pharmaceutical sciences
Recently, an innovative continuous freeze-drying concept for unit doses was proposed, based on spinning the vials during freezing. An efficient heat transfer during drying is essential to continuously process these spin frozen vials. Therefore, the applicability of noncontact infrared (IR) radiation was examined. The impact of several process and f...
De Meyer, Laurens Lammens, Joris Mortier, Séverine Vanbillemont, Brecht Van Bockstal, Pieter-Jan Corver, Jos Nopens, Ingmar Vervaet, Chris De Beer, Thomas
In the pharmaceutical industry, traditional freeze-drying of unit doses is a batch-wise process associated with many disadvantages. To overcome these disadvantages and to guarantee a uniform product quality and high process efficiency, a continuous freeze-drying process is developed and evaluated. The main differences between the proposed continuou...
