Dowling, Jennifer K Becker, Christine E Bourke, Nollaig M Corr, Sinead C Connolly, Dympna J Quinn, Susan R Pandolfi, Paolo P Mansell, Ashley O'Neill, Luke A J
Published in
The Journal of biological chemistry
The apoptosis-associated speck-like protein containing a caspase-activating recruitment domain (ASC) is an essential component of several inflammasomes, multiprotein complexes that regulate caspase-1 activation and inflammation. We report here an interaction between promyelocytic leukemia protein (PML) and ASC. We observed enhanced formation of ASC...
Yao, Chen Yao, Gang-Qing Sun, Ben-Hua Zhang, Changqing Tommasini, Steven M Insogna, Karl
Published in
The Journal of biological chemistry
Colony-stimulating factor 1 (CSF1) is known to promote osteoclast progenitor survival, but its roles in osteoclast differentiation and mature osteoclast function are less well understood. In a microarray screen, Jun dimerization protein 2 (JDP2) was identified as significantly induced by CSF1. Recent reports indicate that JDP2 is required for norma...
Burns, Jonathan K Tomita, Andrew Kapadia, Amy S
Published in
The International journal of social psychiatry
Countries characterized by a large rich-poor gap may be at increased risk of schizophrenia. We suggest that income inequality impacts negatively on social cohesion, eroding social capital, and that chronic stress associated with living in highly disparate societies places individuals at risk of schizophrenia.
Ignacio, Rosa Mistica C Kim, Cheol-Su Kim, Soo-Ki
Published in
Journal of lifestyle medicine
It is widely accepted that chronic inflammation contributes to the pathogenesis of obesity. Researchers have recently discovered that increased inflammatory cytokines and the infiltration and activation of macrophage cells in the adipose tissue are related to chronic obesity. This immunologic dysregulation has led to the development of the classica...
Chi, Zhao-chun Dong, Quan-jiang Geng, Chang-xin
Published in
Infection International
Acute-on-chronic liver failure is a characteristic clinical liver syndrome, which should be differentiated from acute liver failure, acute decompensated liver cirrhosis and chronic liver failure. The pathogenesis of ACLF is not fully understood yet. Viral factors and immune injury have been reported to be the two major pathogenesis. This paper revi...
Shi, Jialiang Chen, Qiyi Yu, Wenkui Shen, Juanhong Gong, Jianfeng He, Changsheng Hu, Yiming Zhang, Juanjuan Gao, Tao Xi, Fengchan
...
Published in
Artificial organs
Pulmonary changes in veno-venous extracorporeal membrane oxygenation (VV-ECMO) are rarely determined. We compared the contribution of VV-ECMO and cannulation based on the observation of pulmonary inflammatory reaction and parenchymal construction in a porcine model of low tidal volume (VT ) ventilation. We also evaluated the effect of adding contin...
Lim, Heung Bin Kim, Seung Hyung
Published in
Toxicological research
Electronic cigarettes (e-cigarettes) are becoming increasingly popular worldwide and their cellular effects warrant further evaluation. In this study, we investigated the effects of an e-cigarette cartridge solution on allergen related asthmatic airway inflammation (AI) and airway hyperresponsiveness (AHR), when it is delivered by intratracheal rou...
Maxson, Julia E Luty, Samuel B MacManiman, Jason D Abel, Melissa L Druker, Brian J Tyner, Jeffrey W
Published in
The Journal of biological chemistry
Mutations in the CSF3 granulocyte colony-stimulating factor receptor CSF3R have recently been found in a large percentage of patients with chronic neutrophilic leukemia and, more rarely, in other types of leukemia. These CSF3R mutations fall into two distinct categories: membrane-proximal mutations and truncation mutations. Although both classes of...
Chung, Hye Won Lim, Jong-Baeck
Published in
World journal of gastroenterology
Gastric carcinoma (GC) is the 4(th) most prevalent cancer and has the 2(nd) highest cancer-related mortality rate worldwide. Despite the incidence of GC has decreased over the past few decades, it is still a serious health problem. Chronic inflammatory status of the stomach, caused by the infection of Helicobacter pylori (H. pylori) and through the...
Bakele, Martina Joos, Melanie Burdi, Sofia Allgaier, Nicolas Pöschel, Simone Fehrenbacher, Birgit Schaller, Martin Marcos, Veronica Kümmerle-Deschner, Jasmin Rieber, Nikolaus
...
Published in
The Journal of biological chemistry
Neutrophils represent the major fraction of circulating immune cells and are rapidly recruited to sites of infection and inflammation. The inflammasome is a multiprotein complex that regulates the generation of IL-1 family proteins. The precise subcellular localization and functionality of the inflammasome in human neutrophils are poorly defined. H...
