Oral cancer is the�6th�most common cancer�worldwide, and more than 30,000 Americans are diagnosed with oral cancer each year. The 5-year survival rate for this group of cancers has been about 50%, despite advances in surgery, radiation, and chemotherapy. In addition to premature death associated with oral cancer, the severe morbidity from can...
Published in Journal of bioscience and bioengineering
Phellinus linteus, a species of mushroom, has been shown to contribute to health benefits, such as anti-inflammatory activity and immunomodulatory efficacy. The aim of this study was to analyze the most effective constituents of P. linteus fermented broths, polysaccharides, and to evaluate their immunoregulatory effects on T cells. Four fermented b...
Published in Advances in experimental medicine and biology
Cigarette smoke (CS) activates inflammatory cells and increases cytokine levels producing local and systemic inflammation. To assess changes in intracellular and extracellular cytokine levels we used human epithelial (A549 cells) and monocyte (THP-1) cell lines grown for 24 h in cigarette smoke-conditioned media. Cytokines were assessed using immun...
Aims: Processes in the development of atherosclerotic lesions can lead to plaque rupture or erosion, which can in turn elicit myocardial infarction or ischaemic stroke. The aims of this study were to determine whether Toll-like receptor 7 (TLR7) gene expression levels influence patient outcome and to explore the mechanisms linked to TLR7 expression...
Published in The Journal of nutritional biochemistry
The incidence of allergies has recently been increasing worldwide. Immunoglobulin E (IgE)-mediated hypersensitivity is central to the pathogenesis of asthma, hay fever and other allergic diseases. Ginger (Zingiber officinale Roscoe) and its extracts have been valued for their medical properties including antinausea, antiinflammation, antipyresis an...
Published in European Spine Journal
PurposeModic changes (MC) are associated with low back pain (LBP). Inflammation is considered as a key factor that triggers symptoms in especially type I MC, but so far of the potential inflammatory candidates only TNFα has been linked to MC. The objective of the study was to analyze a set of inflammatory mediators in human surgical disk samples an...
The purpose of this study is to evaluate the levels of various cytokines in patients with idiopathic condylar resorption (ICR) of the temporomandibular joint (TMJ). Previous research has assessed the roles of cytokines in serum and synovial fluid of patients with autoimmune diseases resulting in joint degeneration. However, limited studies have ass...
Oral cancer is the�6th�most common cancer�worldwide, and more than 30,000 Americans are diagnosed with oral cancer each year. The 5-year survival rate for this group of cancers has been about 50%, despite advances in surgery, radiation, and chemotherapy. In addition to premature death associated with oral cancer, the severe morbidity from can...
Published in Cancer letters
Recent exciting progress in cancer immunotherapy has ushered in a new era of cancer treatment. Immunotherapy can elicit unprecedented durable responses in advanced cancer patients that are much greater than conventional chemotherapy. However, such responses only occur in a relatively small fraction of patients. A positive response to immunotherapy ...
Published in MethodsX
We introduce a method to evaluate the activities of cytokines based on the nuclear transport of NF-κB. A pair of bioluminescent indicators was made for conferring cytokine sensitivity to cervical carcinoma-derived HeLa cells. The principle is based on reconstitution of split fragments of Renilla reniformis luciferase (RLuc) by protein splicing with...
