Episodic memories comprise diverse attributes of experience distributed across neocortical areas. The hippocampus is integral to rapidly binding these diffuse representations, as they occur, to be later reinstated. However, the nature of the information exchanged during this hippocampal-cortical dialogue remains poorly understood. A recent study ha...
While semantic and episodic memory have been shown to influence each other, uncertainty remains as to how this interplay occurs. We introduce a behavioral representational similarity analysis approach to assess whether semantic space can be subtly re-sculpted by episodic learning. Eighty participants learned word pairs that varied in semantic relat...
Humans and other animals can learn and exploit repeating patterns that occur within their environments. These learned patterns can be used to form expectations about future sensory events. Several influential predictive coding models have been proposed to explain how learned expectations influence the activity of stimulus-selective neurons in the v...
When learning, it is often necessary to identify important themes to organize key concepts into categories. In value-directed remembering tasks, words are paired with point values to communicate item importance, and participants prioritize high-value words over low-value words, demonstrating selective memory. In the present study, we paired values ...
A prominent theoretical framework spanning philosophy, psychology, and neuroscience holds that selective attention penetrates early stages of perceptual processing to alter the subjective visual experience of behaviorally relevant stimuli. For example, searching for a red apple at the grocery store might make the relevant color appear brighter and ...
Everyday experience requires processing external signals from the world around us and internal information retrieved from memory. To do both, the brain must fluctuate between states that are optimized for external versus internal attention. Here, we focus on the hippocampus as a region that may serve at the interface between these forms of attentio...
RATIONALE: Alcohol administration and cue-reactivity paradigms are frequently used to screen for the initial efficacy of medications for alcohol use disorder (AUD). While medication effects on the primary outcomes for these paradigms are assumed to be qualitatively related, there is a critical lack of quantitative evidence to support this hypothesi...
Acknowledgements: This work was supported by a Canadian Institutes of Health Research project grant awarded to CAW (PJT-162312). CSC was supported by a Canadian Graduate Scholarship- Master’s level, TJH was supported by a Marshall Graduate Scholarship, and JDS was supported by a UBC Four Year Doctoral Fellowship. This work took place at a UBC campu...
Acknowledgements: We thank Dr Olivier Bertrand for his considerable help with the statistical analysis. We thank Dr Lund for his statistical recommendations and for providing us with his expertise in circular statistics. We thank Dr Becca Goldberg for her assistance with eye dissections. We thank the Editor and three anonymous Reviewers very much f...
Newly formed memories are spontaneously reactivated during sleep, leading to their strengthening. This reactivation process can be manipulated by reinstating learning-related stimuli during sleep, a technique termed targeted memory reactivation. Numerous studies have found that delivering cues during sleep improves memory for simple associations, i...
