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LENERT, PETAR BRUMMEL, RACHEL Field, Elizabeth H. ASHMAN, ROBERT F.
Published in
Journal of Clinical Immunology
Bacterial DNA triggers B-cell proliferation and induces immunoglobulin secretion. Chromatin–IgG complexes activate autoreactive B cells by co-engaging B-cell receptor (BCR) and TLR-9, thus suggesting a role for innate signaling in systemic autoimmunity. Spleen cells from lupus prone Palmerston North (PN) mice produce several fold less IL-12p40 than...
Loginov, V. I. Khodyrev, D. S. Pronina, I. V. Malyukova, A. V. Kazubskaya, T. P. Ermilova, V. D. Gar’kavtseva, R. F. Zabarovskii, E. R. Braga, E. A.
Published in
Molecular Biology
Earlier, methylation of a CpG island in the SEMA3B gene (3p21.31) was observed in cell lines of small-cell and non-small-cell lung carcinoma. According to NCBI (Build 36), that island belonged to intron 1 of the gene. Our study concerns the methylation of two CpG islands, promoter and intronic, in the SEMA3B gene in patients with clear cell renal c...
Loginov, V. I. Rykov, S. V. Fridman, M. V. Braga, E. A.
Published in
Biochemistry (Moscow)
Interaction between microRNA (miRNA) and messenger RNA of target genes at the posttranscriptional level provides fine-tuned dynamic regulation of cell signaling pathways. Each miRNA can be involved in regulating hundreds of protein-coding genes, and, conversely, a number of different miRNAs usually target a structural gene. Epigenetic gene inactiva...
Braga, E. A. Loginov, V. I. Pronina, I. V. Khodyrev, D. S. Rykov, S. V. Burdennyy, A. M. Friedman, M. V. Kazubskaya, T. P. Kubatiev, A. A. Kushlinskii, N. E.
...
Published in
Biochemistry (Moscow)
Methylation of CpG-islands in promoter regions as well as interaction of miRNAs with messenger RNAs of target genes are related to multilayer mechanisms regulating gene expression. The goal of this study was to assess a possibility for miRNA gene methylation to influence indirectly activation of their target genes in lung tumors. By using a unified...
