Liu, Zhongwei Wang, Yuan Pan, Shuo Zhang, Yong Zhu, Haitao Liu, Yunpeng Zhu, Ling Zhang, Junbo
Published in
Biochemical and biophysical research communications
The aim of this study is to investigate the role of platelets in anxiety in myocardial infarction (MI). A protein kinase D (PKD) inhibitor CRT0066101 was administrated to MI rat models. Open-field (OF) test, dark-light transfer (DLT) test and elevated plus maze (EPM) test were used to assess anxiety of animals. Platelets granule releasing was evalu...
Scarsini, Roberto De Maria, Giovanni L Di Gioia, Giuseppe Kotronias, Rafail A Aurigemma, Cristina Zimbardo, Giuseppe Burzotta, Francesco Leone, Antonio M Pesarini, Gabriele Trani, Carlo
...
Published in
Journal of cardiovascular translational research
The reliability of fractional flow reserve (FFR) in aortic stenosis (AS) has been questioned because of the uncertain response to vasodilators. A retrospective multicenter cohort of 114 AS patients who underwent coronary physiology assessment was compared with 154 controls before and after propensity matching adjustment. The difference between rest...
Hou, Zhi-Hui Lu, Bin Li, Zhen-Nan An, Yun-Qiang Gao, Yang Yin, Wei-Hua
Published in
Academic radiology
We sought to compare the prevalence and volume of lipid plaque, fibrous plaque, and calcified plaque in patients with smokers versus nonsmokers. We studied consecutive patients suspected of coronary artery disease and who underwent coronary computed tomography angiography. A structured interview and review of existing clinical data was conducted be...
Homburger, Julian R. Neben, Cynthia L. Mishne, Gilad Zhou, Alicia Y. Kathiresan, Sekar Khera, Amit V.
Published in
Genome Medicine
BackgroundInherited susceptibility to common, complex diseases may be caused by rare, pathogenic variants (“monogenic”) or by the cumulative effect of numerous common variants (“polygenic”). Comprehensive genome interpretation should enable assessment for both monogenic and polygenic components of inherited risk. The traditional approach requires t...
Gordon, Nancy P. Lin, Teresa Y. Rau, Jyoti Lo, Joan C.
Published in
BMC Public Health
BackgroundFew large cohort studies have examined the prevalence of diabetes mellitus (DM), hypertension (HTN), coronary artery disease (CAD), obesity, and smoking among middle-aged and older adults in the major Asian-American ethnic groups and Native Hawaiian/Pacific Islanders (PIs). The aim of this study was to evaluate how prevalence of these con...
Ihdayhid, Abdul Rahman Koh, Jin-Sin Ramzy, John Kumar, Arnav Michail, Michael Brown, Adam Samady, Habib
Published in
Current Cardiology Reports
Purpose of ReviewThe role of fractional flow reserve to guide revascularization in patients with stable angina is well established. The instantaneous wave-free ratio (iFR) is an emerging adenosine-free resting index that is non-inferior to FFR and has potential to streamline the functional evaluation of coronary artery disease. The feasibility and ...
Eltermaa, Mall Jakobson, Maili Utt, Meeme Kõks, Sulev Mägi, Reedik Starkopf, Joel
Published in
BMC Research Notes
ObjectiveCoronary artery disease contributes to noncommunicable disease deaths worldwide. In order to make preventive methods more accurate, we need to know more about the development and progress of this pathology, including the genetic aspects. Humanin is a small peptide known for its cytoprotective and anti-apoptotic properties. Our study looked...
Yap, Jonathan Lim, Weng Khong Sahlén, Anders Chin, Calvin Woon-Loong Chew, Kenneth Michael Yun-Chi Davila, Sonia Allen, John Goh, Vera Tan, Swee Yaw Tan, Patrick
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Published in
BMC Cardiovascular Disorders
BackgroundCardiovascular disease (CVD) imposes much mortality and morbidity worldwide. The use of “deep learning”, advancements in genomics, metabolomics, proteomics and devices like wearables have the potential to unearth new insights in the field of cardiology. Currently, in Asia, there are no studies that combine the use of conventional clinical...
Shen, Ying Dai, Yang Wang, Xiao Qun Zhang, Rui Yan Lu, Lin Ding, Feng Hua Shen, Wei Feng
Published in
Cardiovascular Diabetology
BackgroundControversies exist regarding the optimal blood pressure (BP) level that is safe and provides cardiovascular protection in patients with type 2 diabetes mellitus (T2DM) and coexistent coronary artery disease. Several new glucose-lowering agents have been found to lower BP as well, making the interaction between BP and T2DM even more compl...
Takahara, Mitsuyoshi Iida, Osamu Kohsaka, Shun Soga, Yoshimitsu Fujihara, Masahiko Shinke, Toshiro Amano, Tetsuya Ikari, Yuji
Published in
Cardiovascular Diabetology
BackgroundLower-extremity peripheral artery disease (LE-PAD) and coronary artery disease (CAD) are both pathologically rooted in atherosclerosis, and their shared clinical features regarding the exposure to cardiovascular risk factors have been emphasized. However, comparative data of the two cardiovascular diseases (CVDs) were so far lacking. The ...
