Since benzodiazepines have been used widely in the treatment of anxiety, sleeplessness, and epilepsy, the receptor sites for the benzodiazepine are of prime importance. Quantitative structure-activity relationship (QSAR) studies and receptor modeling via Flexible Atom Receptor Model(FLARM) for the binding affinities of a series of imidazobenzodiaze...
status: published
To address the problems associated with molecular conformations and alignments in the 3D-QSAR studies, we have developed the Flexible Ligand - Atomic Receptor Model (FLARM) 2.0 method. The FLARM 2.0 method has three unique features as compared to other pseudoreceptor model methods: (1) the training ligands are flexibly optimized inside the receptor...
A new dictionary-based text categorization approach is proposed to classify the chemical web pages efficiently. Using a chemistry dictionary, the approach can extract chemistry-related information more exactly from web pages. After automatic segmentation on the documents to find dictionary terms for document expansion, the approach adopts latent se...
In many cases, the programmer may require to encode business rules into the database applications. To do this, a large number of program elements may need to be examined by the programmer to determine which have the capacity to violate a new rule and if so what minimal changes are required to prevent such violations. This process can be time-consum...
