Colimycin was intramuscularly administered to 31 patients with g enitourinary infection and effective in 24 cases. Prompt response in acute infection was more remarkable than any other drug, and it was effective even in obstinate Pseudomonas infection and prophylaxis of infection. Pain at the site of injection was comparatively slight and no side e...
The test of sensitivity to chemotherapeutic ag e n ts wqs performed on becteria isolated from the urine of 105 patients suffering from urinary tract infection, and7the results were compared with the clinical effect of chemotherapeutic agents for these patients. 1) In the acute simple urinary tract infection, the clinical experimen t proved a succee...
Based on the results of culture and sensitivity tests of urine from the patients with urinary tract infections, Colimycin was administered intramuscularly and orally, and following results were obtained. 1) Of 17 patien ts, intramuscularly administered, 13 patients showed improvement both in clinical and bacteriological findings. 2) Of 19 patients,...
Intramuscular injections of colistin-methanesulfonate s o dium at the doses of 66.8m g and 133.6m g producede ffective serum concentrationsf or at least 6-12 hours (Fig. 1). In the patients with renal disturbance, the blood levels were markedly h i g her and the urine levels were lower than normal (Fig. 1-3). In vitro sensitivities of bacteria from...
The minimum antibiotic concentrations for selecting an R plasmid in vivo were determined in germfree rates colonized by two isogenic strains of Escherichia coli, one of which carried an R plasmid. Seventy groups of three gnotobiotic mice were given low doses of ampicillin, colistin, flumequin, gentamicin, tetracycline, or streptomycin via drinking ...
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Published in Chromatographia
Reversed-phase, HPLC methods employing post-column derivatization and fluorescence detection were developed for the determination of the peptide colistin and four aminoglycoside antibiotics in feeds. Extraction of the analytes was by sonication and shaking with dilute hydrochloric acid. Post-column derivatization was performed using orthophtaldiald...
Published in Disease Management and Health Outcomes
Selective digestive decontamination (SDD) involves the use of antibiotics to enhance the colonisation resistance of the gastrointestinal (GI) tract. This eradicates the Gram-negative organisms and fungi, if antifungals are used, which colonise the GI tract and subsequently cause infections in susceptible hosts. It has been used in patients who are ...
Published in Infection
The recovery rates of group B streptococcus (GBS) from anorectal swabs (RS) and vaginal swabs (VS) that were enriched were compared to the routine method to determine the optimal procedure. Separate RS and VS were collected from women attending antenatal clinics. RS and VS were placed in 2 ml enrichment and selective broth. Swabs were inoculated on...
