Yang, Joe Naik, Jaesh Massello, Matthew Ralph, Lewis Dillon, Ryan James
Published in
Infectious Diseases and Therapy
Introduction Imipenem/cilastatin/relebactam (IMI/REL), a combination β-lactam antibiotic (imipenem) with a novel β-lactamase inhibitor (relebactam), is an efficacious and well-tolerated option for the treatment of hospitalized patients with gram-negative (GN) bacterial infections caused by carbapenem-non-susceptible (CNS) pathogens. This study exam...
Miguela-Villoldo, Pedro Moreno, Miguel A. Rodríguez-Lázaro, David Gallardo, Alejandro Hernández, Marta Serrano, Tania Sáez, José L. de Frutos, Cristina Agüero, Montserrat Quesada, Alberto
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Published in
Porcine Health Management
Background Resistance to colistin was an uncommon phenomenon traditionally linked to chromosome point mutations, but since the first description of a plasmid-mediated colistin-resistance in late 2015, transmissible resistance to colistin has become a Public Health concern. Despite colistin is considered as a human last resort antibiotic, it has bee...
Long, Nguyen Phuoc Oh, Jung-Hwa Park, Se-Myo Yen, Nguyen Thi Hai Phat, Nguyen Ky Cho, Yong-Soon Kim, Hyung Min Yoon, Seokjoo Shin, Jae-Gook Kim, Dong Hyun
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Published in
Toxicology and applied pharmacology
The mechanisms underlying colistin-induced toxicity are not fully understood. This study used untargeted metabolomics and transcriptomics to elucidate the molecular processes occurring in the liver and kidney of rats after treatment with colistin methanesulfonate (CMS). Rats were treated with 50 mg/kg CMS (high-dose), 25 mg/kg CMS (low-dose), or ve...
Gorecki, Adrian Musialowski, Marcin Wolacewicz, Mikolaj Decewicz, Przemyslaw Ferreira, Catarina Vejmelkova, Dana Grzesiuk, Malgorzata Manaia, Celia M Bartacek, Jan Dziewit, Lukasz
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Published in
Journal of hazardous materials
Antibiotic resistance is considered one of the biggest threats to public health and has become a major concern for governments and international organizations. Combating this problem starts with improving global surveillance of antibiotic resistance genes (ARGs) and applying standardized protocols, both in a clinical and environmental context, in a...
Drider, Djamel Boukherroub, Rabah Le Devendec, Laetitia Belguesmia, Yanath Hazime, Noura Mourand, Gwenaelle Paboeuf, Frédéric Kempf, Isabelle
Published in
Veterinary microbiology
Colistin is frequently used for the control of post-weaning diarrhoea in pigs. Colistin resistance caused by plasmidic genes is a public health issue. We evaluated, in experimental animal facilities, whether free colistin or colistin-loaded on alginate nanoparticles (colistin/Alg NPs) could select a colistin-resistant Enterotoxigenic Escherichia co...
Kumari, Anju Gupta, Poonam Verma, Himanshu Kumar, Ajay Thakur, Preeti Sharma, Kavish
Published in
Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine
Bartter-like syndrome (BLS) is a constellation of biochemical abnormalities which include metabolic alkalosis, hypokalemia, hypocalcemia, hypomagnesemia with normal kidney function. BLS is a very rare syndrome and can be induced by certain diseases, antibiotics, diuretics, and antineoplastic drugs. Colistin is a polymicrobial bactericidal drug and ...
Niazadeh, Mojtaba Nikkhahi, Farhad Robatjazi, Saeedeh Javadi, Amir Farzam, Seyed Amir Babaei, Samaneh Zeynali, Parisa
Published in
Iranian Journal of Microbiology
Background and Objectives: One of the major causes of urinary tract infections is Klebsiella pneumoniae. Currently, few studies investigated the mechanisms of resistance to colistin in Iran. The current study aimed to determine the prevalence of plasmid and chromosome-mediated resistance to colistin in K. pneumoniae isolates. Materials and Methods:...
Doremus, Casey Marcella, Stephen W Cai, Bin Echols, Roger M
Published in
Infectious diseases and therapy
Colistin is used to treat severe antibiotic-resistant Gram-negative infections (GNIs). With the rise of antibiotic resistance, colistin has been used increasingly as a 'last-line' therapy for multidrug-resistant GNIs. We evaluated the incidence of acute kidney injury (AKI) and mortality among patients receiving colistin or one of the new β-lactam/β...
Bharathi, K S Bhat, Ananda Pruthi, Gegal Simha, Parimala P
Published in
Annals of cardiac anaesthesia
Ventilator-associated pneumonia (VAP) with multidrug-resistant (MDR) gram negative organisms is a common problem in intensive care unit (ICU). Aerosolized antibiotics enhance the efficacy of systemic antibiotics when added as adjuvants. The primary objective of the study was to compare the clinical and bacteriological outcome of patients with VAP w...
Khalifeh, Malak El-Lakany, Abdalla Soubra, Lama
Published in
Current drug safety
Colistin use has increased because of the emergence of infections caused by resistant gram-negative bacteria. Acute kidney injury (AKI) remains a treatment-limiting factor for widespread colistin clinical use. This study aimed at determining the incidence and the factors associated with the development of colistin-induced AKI. A retrospective obser...
