Tang, Richard Lopes, Vrishali L Caffrey, Aisling R
Published in
Expert opinion on drug safety
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening skin reactions. Colistin is a last resort antibiotic with a historically poor safety profile. The association between colistin and SJS/TEN has not been previously quantified. We identified colistin and SJS/TEN adverse event reports from the Food and Drug Admini...
Narimisa, Negar Goodarzi, Forough Bavari, Shirin
Published in
Annals of clinical microbiology and antimicrobials
Klebsiella pneumoniae is a gram-negative pathogen common cause of nosocomial infections. Colistin is a last resort antibiotic to treat infections caused by K. pneumoniae. In recent years, the resistance rate to colistin has increased in K. pneumoniae. This study evaluated the prevalence of colistin resistance of K. pneumoniae isolates in Iran using...
Dadashi, Masoud Sameni, Fatemeh Bostanshirin, Nazila Yaslianifard, Somayeh Khosravi-Dehaghi, Nafiseh Nasiri, Mohammad Javad Goudarzi, Mehdi Hashemi, Ali Hajikhani, Bahareh
Published in
Journal of global antimicrobial resistance
The continuing rise in infections caused by multidrug-resistant (MDR) bacteria is one of the most serious public-health issues in society today. Colistin is a last-resort antimicrobial drug used to treat infections caused by MDR Gram-negative bacteria, therefore resistance to this antibiotic is extremely hazardous. The current study aimed to evalua...
Meysam, Sharifzadeh Khosravi, Zahra Rashti, Roshanak Qorbani, Mostafa Assadi, Farahnak Hayatshahi, Alireza Parin, Tanzifi Faghihi, Toktam
Published in
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Colistin is one of the last resort antibiotic options for resistant gram-negative pathogens. Renal injury is the most common side effect of colistin. Characteristics of nephrotoxicity are well described in adults. However, this data is sparse in children. In this study we evaluated the incidence, severity, time course and risk factors of colistin n...
Mirjalili, Mahtabalsadat Mirzaei, Ehsan Vazin, Afsaneh
Published in
European Journal of Medical Research
Background Colistin is a polymyxin antibiotic which has been used for treatment of Gram-negative infections, but it was withdrawn due to its nephrotoxicity. However, colistin has gained its popularity in recent years due to the reemergence of multidrug resistant Gram-negative infections and drug-induced toxicity is considered as the main obstacle f...
Coz, Elsa Jouy, Eric Cazeau, Géraldine Jarrige, Nathalie Perrin-Guyomard, Agnes Hemonic, Anne Poissonnet, Alexandre Urban, Delphine Chevance, Anne Delignette-Muller, Marie Laure
...
The discovery of the plasmid resistance gene to colistin mcr-1 in 2015, profoundly changed the way this widely used molecule in veterinary medicine in France was considered. National management measures have been set up to reduce its use in animals, in line with European recom-mendations. Two objectives were defined: that of the AMEG in 2016, to re...
Wang, Sheng-Huei Yang, Kuang-Yao Sheu, Chau-Chyun Chen, Wei-Cheng Chan, Ming-Cheng Feng, Jia-Yih Chen, Chia-Min Wu, Biing-Ru Zheng, Zhe-Rong Chou, Yu-Ching
...
Published in
Critical Care
Background The importance or necessity of a loading dose when prescribing intravenous colistin has not been well established in clinical practice, and approximate one-third to half of patients with carbapenem-resistant gram-negative bacteria (CRGNB) infection did not receive the administration of a loading dose. The aim of this study is to investig...
Dai, Chongshan Li, Meng Sun, Tun Zhang, Yuan Wang, Yang Shen, Zhangqi Velkov, Tony Tang, Shusheng Shen, Jianzhong
Published in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Colistin therapy can cause pulmonary toxicity, however, our understanding of the underlying molecular mechanism remains incomplete. This study aimed to investigate the molecular mechanism of colistin-induced pulmonary toxicity in vitro and in vivo. Our results showed that intraperitoneal colistin treatment significantly increased the expression of ...
Lu, Jiayue Yang, Yongchun Wu, Yuchen Liu, Congcong Zeng, Yu Lei, Lei Song, Houhui Zhang, Rong
Published in
Journal of infection and public health
Antimicrobial resistance is a quintessential One Health issue, among the most serious 21st century global threats in human and veterinary medicine. Wild animals are usually not directly exposed to clinically relevant antibiotics; however, antibacterial resistance in wild animals has been increasingly reported worldwide in parallel to the situation ...
Yang, Joe Naik, Jaesh Massello, Matthew Ralph, Lewis Dillon, Ryan James
Published in
Infectious Diseases and Therapy
Introduction Imipenem/cilastatin/relebactam (IMI/REL), a combination β-lactam antibiotic (imipenem) with a novel β-lactamase inhibitor (relebactam), is an efficacious and well-tolerated option for the treatment of hospitalized patients with gram-negative (GN) bacterial infections caused by carbapenem-non-susceptible (CNS) pathogens. This study exam...
