Alkhulaifi, Zeina MM Mohammed, Khairallah AS
Published in
Iranian Journal of Microbiology
Background and Objectives: The steady increase in the spread of multidrug-resistant Pseudomonas aeruginosa (MDR) has become a major threat to the global health systems, including Iraq. This study aimed to investigate the prevalence and the molecular basis of antibiotic resistance in Pseudomonas aeruginosa isolated from clinical and environmental sa...
Öz Gergin, Özlem Gergin, İsmail Şamil Pehlivan, Sibel Seckin Cengiz Mat, Ozge Turan, Işıl Tuğçe Bayram, Adnan Gönen, Zeynep Burçin Korkmaz, Şeyda Bıcer, Cihangir Yildiz, Karamehmet
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Published in
Toxicology mechanisms and methods
Colistin is an effective antibiotic against multidrug-resistant gram-negative bacterial infections; however, neurotoxic effects are fundamental dose-limiting factors for this treatment. Stem cell therapy is a promising method for treating neuronal diseases. Multipotent mesenchymal stromal cells (MSC) represent a promising source for regenerative me...
Rhouma, Mohamed Madec, Jean-Yves Laxminarayan, Ramanan
Antimicrobial resistance (AMR) poses a serious threat to human, animal and environmental health worldwide. Colistin has regained importance as a last-resort treatment against multi-drug-resistant Gram-negative bacteria. However, colistin resistance has been reported in various Enterobacteriaceae species isolated from several sources. The 2015 disco...
Adel, Nagla Khedr, Reham Elanany, Mervat Zaki, Hala F. Hafez, Hanafy El-Abhar, Hanan
Published in
Annals of African Medicine
Background: Carbapenem resistant Enterobacteriacae (CRE) bloodstream infection (BSI) causes complicated infections, especially in immunocompromised patients. This study aimed to assess the renal toxicity and the efficacy of therapy with colistin in a cohort of pediatric cancer patients with BSIs due to CRE and sensitivity to colistin. Patients and ...
Guillaume, Dalmasso Racha, Beyrouthy Sandrine, Brugiroux Etienne, Ruppé Laurent, Guillouard Virginie, Bonnin Pierre, Saint-Sardos Amine, Ghozlane Vincent, Gaumet Nicolas, Barnich
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Published in
Microbiome
Background The plasmid-mediated resistance gene mcr-1 confers colistin resistance in Escherichia coli and paves the way for the evolution to pan-drug resistance. We investigated the impact of mcr- 1 in gut colonization in the absence of antibiotics using isogenic E. coli strains transformed with a plasmid encoding or devoid of mcr-1 . Results In gn...
Awad, Wedad B Alsheyyab, Farah Nazer, Lama Mahmoud, Naser
Published in
Clinical Medicine Insights. Case Reports
Introduction: Anaphylaxis is an acute, life-threatening, multi-system syndrome that has been reported with a wide range of medications. Though anaphylaxis usually has a rapid onset, we describe a patient who developed anaphylaxis to intravenous colistin after 28 days of daily administration. Case presentation: A 20 years-old Caucasian male patient,...
Feng, Jia-Yih Huang, Jhong-Ru Lee, Chang-Ching Tseng, Yen-Han Pan, Sheng-Wei Chen, Yuh-Min Yang, Kuang-Yao
Published in
Annals of Intensive Care
Background Adverse reactions, especially nephrotoxicity, are great concerns of intravenous colistin treatment. The role of substitutive nebulized colistin in treating nosocomial pneumonia caused by carbapenem-resistant Gram-negative bacterial (CR-GNB) in critically ill patients remains unknown. Methods This retrospective study enrolled patients wit...
Thaotumpitak, Varangkana Sripradite, Jarukorn Atwill, Edward R Jeamsripong, Saharuetai
BackgroundTilapia is a primary aquaculture fish in Thailand, but little is known about the occurrence of antimicrobial resistance (AMR) in Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae colonizing healthy tilapia intended for human consumption and the co-occurrence of these AMR bacteria in the cultivation water.MethodsThis study determi...
Momenzadeh, Mahnaz Soltani, Rasool Shafiee, Fatemeh Hakamifard, Atousa Pourahmad, Morteza Abbasi, Saeed
Published in
Research in Pharmaceutical Sciences
Background and purpose: The treatment of ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) is still a great challenge. This study evaluated the effectiveness of the colistin/levofloxacin regimen compared to the usual colistin/meropenem regimen in the treatment of patients with VAP caused by CRAB. Ex...
Formenti, Nicoletta Guarneri, Flavia Bertasio, Cristina Parisio, Giovanni Romeo, Claudia Scali, Federico Birbes, Laura Boniotti, Maria Beatrice Diegoli, Giuseppe Candela, Loredana
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Published in
Antimicrobial resistance and infection control
Wastewater-based surveillance enabled the first detection of the mobile colistin resistance gene mcr-10 in Italy. This plasmid-borne resistance gene was found in strains of Klebsiella quasipneumoniae isolated from samples of human raw sewage collected over several months. Although the isolates were phenotypically susceptible to colistin, the emerge...
