Tseng, Cheng-Yin Sun, Mao-Feng Kao, Tzu-Chien Li, Tsai-Chung Lin, Ching-Ting
Published in
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
The incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP) has rapidly increased. This study aimed to assess the effect of Coptis chinensis and its compounds on the minimal inhibitory concentrations (MICs) of eight antibiotics against CRKP. Cell cultures were used to investigate the effects of C. chinensis and its compounds on the MICs of e...
Hakeam, Hakeam A Askar, Ghadi Al Sulaiman, Khalid Mansour, Reem Al Qahtani, Maha M Abbara, Dana Aldhayyan, Nada Dyab, Nariman Afaneh, Liyan Islami, Muna
...
Published in
Journal of infection and public health
Ceftolozane-tazobactam is an emerging treatment for severe infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa. However, limited data support its use in bacteremia treatment. This study aimed to assess the effectiveness of the treatment of MDR P. aeruginosa bacteremia using ceftolozane-tazobactam-based or colistin-based regime...
Dutta, Somnath Liu, Nianzi Gao, Yuefeng Beck, Lily Wang, Xiang
Published in
Bioorganic & medicinal chemistry letters
Multidrug-resistant (MDR) Gram-negative bacteria are an urgent and rapidly spreading threat to human health with limited treatment options. Previously, we discovered a novel [1,2,5]oxadiazolo[3,4-b]pyrazine-containing compound (1) that selectively re-sensitized a variety of MDR Gram-negative bacteria to colistin, one of the last-resort antibiotic. ...
Eze, Emmanuel C Falgenhauer, Linda El Zowalaty, Mohamed E
Published in
Journal of global antimicrobial resistance
Acinetobacter baumannii is a significant opportunistic pathogen causing nosocomial infections. Infections caused by A. baumannii are often difficult to treat because this bacterium is often multidrug-resistant and shows high environmental adaptability. Here, we report on the analysis of three A. baumannii strains isolated from hospital effluents in...
Basardeh, Eilnaz Piri-Gavgani, Somayeh Soltanmohammadi, Behnoush Ghanei, Mostafa Omrani, Mir Davood Soezi, Mahdieh Shokrgozar, Mohammad Ali Azizi, Masoumeh Fateh, Abolfazl Vaziri, Farzam
...
Published in
Iranian Journal of Basic Medical Sciences
Objective(s): The high resistance rate of Acinetobacter baumannii and the limited number of available antibiotics have prompted a worldwide effort to develop effective antimicrobial agents. Accordingly, identifying single-chain variable fragment antibodies (scFvs), capable of exerting direct antibacterial activity in an immune system-independent ma...
Maccari, Ana Paula Baretta, Dilmar Paiano, Diovani Oliveira Filho, Luís Carlos Iuñes Ramos, Fernando Sousa, Jose Paulo Klauberg-Filho, Osmar
Published in
Environmental science and pollution research international
This study aimed to evaluate the effects of untreated pig manure from diets incorporating growth-promoting supplements (antibiotics and Zn oxide) on the survival and reproduction of Eisenia andrei earthworms. The tested manures were obtained from four different groups of pigs fed with four different diets: CS, a diet based on corn and soymeal; TR, ...
Lee, Do-Hoon Cha, Ju-Hee Kim, Dae-Wi Lee, Kihyun Kim, Yong-Seok Oh, Hyo-Young Cho, You-Hee Cha, Chang-Jun
Published in
Microbiome
The increasing prevalence of resistance against the last-resort antibiotic colistin is a significant threat to global public health. Here, we discovered a novel colistin resistance mechanism via enzymatic inactivation of the drug and proposed its clinical importance in microbial communities during polymicrobial infections. A bacterial strain of the...
Menon, Nitasha D Penziner, Samuel Montaño, Elizabeth T Zurich, Raymond Pride, David T Nair, Bipin G Kumar, Geetha B Nizet, Victor
Bacteriophage (phage) therapy is an alternative to traditional antibiotic treatments that is particularly important for multidrug-resistant pathogens, such as Pseudomonas aeruginosa. Unfortunately, phage resistance commonly arises during treatment as bacteria evolve to survive phage predation. During in vitro phage treatment of a P. aeruginosa-type...
Lomakina, Galina Yu Ugarova, Natalia N
Published in
Biophysical reviews
The bioluminescent luciferin-luciferase reaction is based on the oxidation of D-luciferin by oxygen in the presence of ATP and magnesium ions, catalyzed by firefly luciferase. The possibilities of using this reaction to study the influence of external effectors of a physical and chemical nature (temperature exposure, additions of drugs, membrane-ac...
Sushmasri, K Joseph, Joveeta Chaurasia, Sunita R Ramachandran, Charanya Roy, Sanhita
Published in
Indian journal of ophthalmology
To assess the efficacy of the addition of polymyxin E (colistin) in the McCarey-Kaufman (MK) corneal storage solution against multi-drug resistant strains of Enterobacteriaceae, Staphylococcus aureus, and Candida spp. A standard micro broth dilution test and a checkerboard assay were performed for five multi-drug resistant (MDR) clinical strains of...
