Cui, Xiao-die Liu, Xiao-kang Ma, Xiao-yuan Li, Shuai-hua Zhang, Jun-kai Han, Rong-jia Yi, Kai-fang Liu, Jian-hua Pan, Yu-shan He, Dan-dan
...
Published in
mSphere
Colistin is last-resort antibiotic used to treat serious clinical infections caused by MDR bacterial pathogens. The recent emergence of transferable plasmid-mediated COL resistance gene mcr-1 has raised the specter of a rapid worldwide spread of COL resistance. Coupled with the fact of barren antibiotic development pipeline nowadays, a critical app...
Jafari-Ramedani, Saghar Nazari, Maryam Arzanlou, Mohsen Peeri-Dogaheh, Hadi Sahebkar, Amirhossein Khademi, Farzad
Published in
BMC microbiology
Pseudomonas aeruginosa is a common cause of nosocomial infections. However, the emergence of multidrug-resistant strains has complicated the treatment of P. aeruginosa infections. While polymyxins have been the mainstay for treatment, there is a global increase in resistance to these antibiotics. Therefore, our study aimed to determine the prevalen...
Feng, Jun Xu, Zhen Zhuang, Yuan Luo, Jiayuan Chen, Yong Wu, Yitong Fei, Jiayi Liu, Mingxiang Xia, Jiahui Zhang, Jing
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Published in
International journal of antimicrobial agents
The rapid dissemination of the mcr-1 gene via plasmid-mediated transfer has raised concerns regarding the efficacy of colistin as a last-resort treatment for multidrug-resistant Gram-negative bacterial infections. Current mcr-1 gene detection methods mainly focus on cultured bacteria, which is a complex and time-consuming process requiring skilled ...
Jeon, Cheon-Hoo Kim, Si-Ho Kim, Hyoung-Tae Park, Kyoung-Jin Wi, Yu Mi
Published in
Journal of infection and public health
Acinetobacter baumannii, a common carbapenem-resistant gram-negative bacillus, usually causes nosocomial infections. Colistin has been used for carbapenem-resistant A. baumannii (CRAB) infections; however, only a few studies have evaluated colistin as a treatment option compared to appropriate controls. We investigated the effectiveness of colistin...
Son, Ji-Young Kim, Semi Porsuk, Tuğçe Shin, Sooyoung Choi, Yeo Jin
Published in
Journal of infection and public health
Colistin is a viable option for multidrug resistant gram-negative bacteria emerged from inappropriate antibiotic use. Nonetheless, suboptimal colistin concentrations and nephrotoxicity risks hinder its clinical use. Thus, the aim of this study is to investigate clinical outcomes in correlation with pharmacokinetic differences and infection types in...
Phomsisavath, Vilaiphone Roberts, Tamalee Seupsanith, Amphayvanh Robinson, Matthew T. Nammanininh, Phounsavanh Chanthavong, Somphaivanh Chansamouth, Vilada Vongsouvath, Manivanh Theppangna, Watthana Christensen, Peter
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Published in
One Health
Background In Laos, colistin is not currently registered for use in humans. This One Health study aimed to estimate the prevalence of meat-producing pigs carrying colistin-resistant Escherichia coli, and investigate if E. coli causing invasive human infections were colistin-resistant. Methods Between September 2022 and March 2023, rectal swabs were...
Wang, Xuelin Cui, Yong Wang, Zhaohui Jiang, Huilin Ma, Lei Li, Wenwen Yang, Xinyi Zhang, Jinghai Zhao, Yongshan Li, Guoqing
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Published in
International journal of biological macromolecules
The emergence and widespread of multidrug-resistant Gram-negative bacteria have posed a severe threat to human health and environmental safety, escalating into a global medical crisis. Utilization of antibiotic adjuvants is a rapid approach to combat bacterial resistance effectively since the development of new antimicrobial agents is a formidable ...
Sohrabi, Maryam Pirbonyeh, Neda Alizade Naini, Mahvash Rasekhi, Alireza Ayoub, Abbas Hashemizadeh, Zahra Shahcheraghi, Fereshteh
Published in
BMC Infectious Diseases
Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections are a major public health problem, necessitating the administration of polymyxin E (colistin) as a last-line antibiotic. Meanwhile, the mortality rate associated with colistin-resistant K. pneumoniae infections is seriously increasing. On the other hand, importance of administr...
Sabala, Rana Fahmi Fukuda, Akira Nakajima, Chie Suzuki, Yasuhiko Usui, Masaru Elhadidy, Mohamed
Published in
Journal of infection and public health
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a great public health problem and is associated with many disease outbreaks and high mortality rates. Alarmingly, K. pneumoniae has been isolated from food in several recent studies. This study aimed to investigate the prevalence and characteristics of CRKP in food samples from Egypt. A total of ...
Wang, Ching-Hsun Siu, L Kristopher Chang, Feng-Yee Tsai, Yu-Kuo Huang, Li-Yueh Lin, Jung-Chung
Published in
BMC microbiology
The current understanding of acquired chromosomal colistin resistance mechanisms in Enterobacterales primarily involves the disruption of the upstream PmrAB and PhoPQ two-component system (TCS) control caused by mutations in the regulatory genes. Interestingly, previous studies have yielded conflicting results regarding the interaction of regulator...