Albayrak, Aslınur Özger, Hasan Selçuk Başgut, Bilgen Aygencel Bıkmaz, Gülbin Karahalil, Bensu
Published in
Journal of chemotherapy (Florence, Italy)
This study aims to evaluate the clinical pharmacist's contribution impact on the appropriate use of colistin. Our study was conducted prospectively in patients in the Internal Diseases Intensive Care Unit of Gazi University Medical Faculty Hospital for eight months. The first four months of the study were with the observation group, while the next ...
İzci, Feyza Ture, Zeynep Dinc, Gokcen Yay, Arzu Hanım Eren, Esma Eryılmaz Bolat, Demet Gönen, Zeynep Burcin Ünüvar, Gamze Kalın Yıldız, Orhan Aygen, Bilgehan
...
Published in
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
This study examines the role of mesenchymal stem cells (MSCs) in an experimental sepsis model developed with colistin-resistant Acinetobacter baumannii (CRAB). BALB-c mice were divided into treatment groups (MSC, MSC + colistin (C)-fosfomycin (F), and C-F and control groups (positive and negative)). CRAB was administered to mice through intraperito...
Bayatinejad, Ghazal Salehi, Mohammadreza Beigverdi, Reza Halimi, Shahnaz Emaneini, Mohammad Jabalameli, Fereshteh
Published in
BMC microbiology
Hospital infections such as ventilator-associated pneumonia (VAP) due to multidrug-resistant Klebsiella pneumoniae (MDR-KP) strains have increased worldwide. In addition, biofilm production by these resistant isolates has confronted clinicians with higher treatment failure and infection recurrence. Given the paucity of new agents and limited data o...
Zheng, Zihao Shao, Ziqiang Lu, Lihai Tang, Siyu Shi, Kai Gong, Fangxiao Liu, Jingquan
Published in
BMC infectious diseases
The rapid global emergence and spread of carbapenem-resistant Gram-negative bacilli (CR-GNB) is recognized as a major public health concern, and there are currently few effective treatments for CR-GNB infection. The aim of this study was to investigate the clinical characteristics and outcomes of patients with CR-GNB infections treated with ceftazi...
Appel, Tobias Manuel Stein, Claudia Brandt, Christian Rödel, Jürgen Frietsch, Jochen J Miethke, Jenny Hochhaus, Andreas Hilgendorf, Inken
Published in
Infection
Metallo-β-lactamases (MBL) are a threat to public health, since they dramatically limit the use of β-lactams. We report the isolation of a multidrug-resistant Hafnia paralvei strain from urine and a rectal swab of a female patient after allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome. Antimicrobial susceptibility tes...
Baliga, Pallavi Goolappa, Puneeth Thadooru Shekar, Malathi Kallappa, Girisha Shivani
Published in
Probiotics and antimicrobial proteins
Multidrug-resistant bacteria are emerging as a major global threat to public health. Bacteriophages are an important source of antimicrobial enzymes and could be developed as an alternative antibiotic candidate. This study investigates the antibacterial capacity of the endolysin LysE against Aeromonas hydrophila. The endolysin LysE gene was cloned ...
Coz, Elsa Jouy, Eric Cazeau, Géraldine Jarrige, Nathalie Chauvin, Claire Delignette-Muller, Marie-Laure
Colistin resistance has been the subject of much attention since mcr genes encoding plasmid-mediated colistin resistance description in 2015. To date, surveillance data about resistance levels encountered in food-producing animals are scarce. In France, the Resapath dataset, consisting in a large collection of disk diffusion antibiogram results tra...
Landa, Guillermo Alejo, Teresa Sauzet, Theo Laroche, Julian Sebastian, Victor Tewes, Frederic Arruebo, Manuel
Compared to parenteral administration of colistin, its direct pulmonary administration can maximize lung drug deposition while reducing systemic adverse side effects and derived nephrotoxicity. Current pulmonary administration of colistin is carried out by the aerosolization of a prodrug, colistin methanesulfonate (CMS), which must be hydrolized to...
Yasugi, Mayo Hatoya, Shingo Motooka, Daisuke Kondo, Daisuke Akiyoshi, Hideo Horie, Masayuki Nakamura, Shota Shimada, Terumasa
Published in
Veterinary microbiology
The emergence of mcr plasmid-mediated colistin-resistant extended-spectrum β-lactamase (ESBL)-producing Enterobacterales among companion dogs and cats poses a risk of the animals acting as reservoirs for cross-species transmission. However, current knowledge of mcr-harboring ESBL-producing Enterobacterales in companion dogs and cats is still limite...
Öz Gergin, Özlem Gergin, İsmail Şamil Pehlivan, Sibel Seckin Cengiz Mat, Ozge Turan, Işıl Tuğçe Bayram, Adnan Gönen, Zeynep Burçin Korkmaz, Şeyda Bıcer, Cihangir Yildiz, Karamehmet
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Published in
Toxicology mechanisms and methods
Colistin is an effective antibiotic against multidrug-resistant gram-negative bacterial infections; however, neurotoxic effects are fundamental dose-limiting factors for this treatment. Stem cell therapy is a promising method for treating neuronal diseases. Multipotent mesenchymal stromal cells (MSC) represent a promising source for regenerative me...
