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Maritzen, Tanja Keating, Damien J Neagoe, Ioana Zdebik, Anselm A Jentsch, Thomas J
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
ClC-3 is an intracellular chloride transport protein known to reside on endosomes and synaptic vesicles. The endogenous protein has been notoriously difficult to detect in immunohistological experiments because of the lack of reliable antibodies. Using newly generated antibodies, we now examine its expression pattern at the cellular and subcellular...
Bali, Kiran Kumar Selvaraj, Deepitha Satagopam, Venkata Lu, Jianning Schneider, Reinhard Kuner, Rohini
Cancer pain remains a major challenge and there is an urgent demand for the development of specific mechanism-based therapies. Various diseases are associated with unique signatures of expression of microRNAs (miRNAs), which reveal deep insights into disease pathology. Using a comprehensive approach combining genome-wide miRNA screening, molecular ...
Bali, Kiran Kumar Selvaraj, Deepitha Satagopam, Venkata P Lu, Jianning Schneider, Reinhard Kuner, Rohini
Published in
EMBO molecular medicine
Cancer pain remains a major challenge and there is an urgent demand for the development of specific mechanism-based therapies. Various diseases are associated with unique signatures of expression of microRNAs (miRNAs), which reveal deep insights into disease pathology. Using a comprehensive approach combining genome-wide miRNA screening, molecular ...
Li, Mengmeng Chen, Xiao Chen, Liang Chen, Kai Zhou, Jianye Song, Jiangping
Published in
Journal of Translational Medicine
BackgroundMicroRNAs (miRNAs) are non-coding RNAs that function as regulators of gene expression and thereby contribute to the complex disease phenotypes. Hypertrophic cardiomyopathy (HCM) and Dilated cardiomyopathy (DCM) can cause sudden cardiac death and eventually develop into heart failure. However, they have different clinical and pathophysiolo...
Ma, Ming-Ming Jin, Chen-Chen Huang, Xue-Lian Sun, Lu Zhou, Hui Wen, Xue-Jun Huang, Xiong-Qing Du, Jie-Yi Sun, Hong-Shuo Ren, Zhu-Xiao
...
Published in
Acta pharmacologica Sinica
Obesity induces accumulation of adipose tissue macrophages (ATMs) and ATM-driven inflammatory responses that promote the development of glucose and lipid metabolism disorders. ClC-3 chloride channel/antiporter, encoded by the Clcn3, is critical for some basic cellular functions. Our previous work has shown significant alleviation of type 2 diabetes...
