Ajengui, Arwa Bertolini, Edoardo Ligorio, Angela Chebil, Samir Ippolito, Antonio Sanzani, Simona Marianna
Published in
Plant Cell Reports
Key messageHost perception of Phytophthora nicotianae switching to necrotrophy is fundamental for disease tolerance of citrus. It involves an HR-like response, strengthening of the cell wall structure and hormonal signaling.AbstractStem rot caused by P. nicotianae is a worldwide disease of several important crops, including citrus. Given the growin...
Ratamess, Nicholas A Bush, Jill A Stohs, Sidney J Ellis, Nicole L Vought, Ira T O'Grady, Elizabeth A Kuper, Jeremy D Hasan, Saif B Kang, Jie Faigenbaum, Avery D
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Published in
Phytotherapy research : PTR
The purpose was to examine cardiovascular responses to supplementation with p-synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects were given (in double-blind manner) either 103 mg of p-synephrine (S), 233 mg of caffeine +104 mg of p-synephrine (LC + S), 240 mg of caffeine (LC), 337 mg of caffeine +46 mg of p-syn...
Deshmukh, N S Stohs, S J Magar, C C Kadam, S B
Published in
Regulatory toxicology and pharmacology : RTP
The primary active constituent in bitter orange extract (BOE) is p-synephrine. This study assessed the safety of a BOE standardized to 50% p-synephrine following short-term exposure to rats and by the Ames Test. Following 5000 mg/kg of the extract orally to female rats all animals survived. Administration at 2000 mg/kg to female rats for four days ...
Gutiérrez-Hellín, Jorge Del Coso, Juan
Published in
Phytotherapy research : PTR
The aim of this investigation was to determine the effects different doses of p-synephrine on maximal fat oxidation during exercise. Seventeen healthy subjects volunteered to participate in a double-blind and randomised experimental design composed of four identical experimental trials. On four trials separated by 72 h, participants ingested a plac...
Stohs, Sidney J
Published in
Phytotherapy research : PTR
Citrus aurantium L. (bitter orange) extracts that contain p-synephrine as the primary protoalkaloid are widely used for weight loss/weight management, sports performance, appetite control, energy, and mental focus and cognition. Questions have been raised about the safety of p-synephrine because it has some structural similarity to ephedrine. This ...
Doctorian, Tanya Do, Bao
Published in
Journal of cardiology cases
Aortic dissection in young patients presents a clinical and diagnostic challenge. Atypical symptoms of ascending aortic dissection can delay presentation and diagnosis. Here, we describe a patient with delayed diagnosis of an atypical presentation of ascending aortic dissection after using a synephrine-containing pre-workout supplement. The diagnos...
Bakhyia, Nadiya Dusemund, Birgit Richter, Klaus Lindtner, Oliver Hirsch-Ernst, Karen Ildico Schäfer, Bernd Lampen, Alfonso
Published in
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
Synephrin ist ein sympathomimetisches Phenylethylaminderivat aus Zitrusfrüchten. Der Pflanzeninhaltsstoff wird in Form von Extrakten aus Bitterorangen (Citrus aurantium) und oft in Kombination mit Koffein Nahrungsergänzungsmitteln zugesetzt, die zur Gewichtsabnahme bzw. Steigerung der körperlichen Leistungsfähigkeit angeboten werden. Im vorliegende...
Oueslati, Amel Salhi-Hannachi, Amel Luro, François Vignes, Hélène MOURNET, Pierre Ollitrault, Patrick
The mandarin horticultural group is an important component of world citrus production for the fresh fruit market. This group formerly classified as C. reticulata is highly polymorphic and recent molecular studies have suggested that numerous cultivated mandarins were introgressed by C. maxima (the pummelos). C. maxima and C. reticulata are also the...
Deshmukh, N S Stohs, S J Magar, C C Kale, A Sowmya, B
Published in
Toxicology reports
Bitter orange (Citrus aurantium L.) extracts are widely used in dietary supplements and bitter oranges are used in various juices and food products. p-Synephrine, the primary active constituent, comprises approximately 90% of total protoalkaloids. This study, performed per OECD 408 guidance, examined the 90-day subchronic safety/toxicity of an extr...
Sanei-Dehkordi, Alireza Sedaghat, Mohammad Mehdi Vatandoost, Hassan Abai, Mohammad Reza
Published in
Journal of arthropod-borne diseases
Recently, essential oils and extracts derived from plants have received much interest as potential bio-active agents against mosquito vectors. The essential oils extract from fresh peel of ripe fruit of Citrus aurantium and Citrus paradisi were tested against mosquito vector Anopheles stephensi (Diptera: Culicidae) under laboratory condition. Then ...
