BACKGROUND:Low-level laser therapy (LLLT) also called Photobiomodulation therapy (PBMT) could reduce oral mucositis (OM) incidence and severity in head and neck cancer patients treated by chemoradiotherapy, however randomised data about efficacy and safety are missing with curative dose 4 J/cm2.METHODS:This phase III trial was conducted in patients...
Published in Radiation Oncology
BackgroundPatients with regional lymph node recurrence after radical resection of esophageal cancer have poor therapeutic outcomes. Currently, there is no standard treatment for regional lymph node recurrence, and its prognostic risk factors are not well-understood. This study retrospectively analyzed 83 patients with postoperative regional lymph n...
Published in Clinical colorectal cancer
Initial treatment with either neoadjuvant chemoradiation (CRT) or induction FOLFOX (5-Fluorouracil, leucovorin, and oxaliplatin) chemotherapy followed by CRT is considered standard treatment for locally advanced rectal cancer. We compared patient-reported outcomes (PRO) during CRT in patients who had received induction chemotherapy versus those who...
Published in Journal of gastrointestinal cancer
Upper esophageal carcinomas are uncommon but confer a poor prognosis. However, there is scarcity of data regarding outcomes of definitive chemoradiotherapy for cervical and upper thoracic esophageal squamous cell carcinoma in Iran. In this retrospective cohort study, we analyzed data of patients with squamous cell carcinoma of cervical and upper th...
Published in World Journal of Surgical Oncology
BackgroundWe aimed to evaluate the efficacy and safety of 5-fluorouracil-based neoadjuvant chemoradiotherapy (NACRT) in patients with resectable/borderline resectable pancreatic ductal adenocarcinoma (PDAC).MethodsThis retrospective study investigated the clinicopathological features and > 5-year survival of patients with T3/T4 PDAC who underwent N...
Published in Orthopaedic surgery
To evaluate survival and functional outcomes in surgically-treated spinal metastasis patients and to identify the prognostic value of the remaining options for systemic treatment. The current study reviewed 100 consecutive patients who received surgery for spinal metastasis in a single center from March 2012 to June 2016. The decision for surgery h...
Published in Journal of cachexia, sarcopenia and muscle
Treatment-related toxicities and decreased levels of patient performance during cancer therapy might contribute to body composition changes and thereby impact outcomes. However, the effect of longitudinal body composition changes on outcomes in patients with advanced endometrial cancer is unknown. This study investigated the association between bod...
Published in Journal of Pharmaceutical Health Care and Sciences
BackgroundOral mucositis is a frequent and severe adverse event in patients undergoing chemoradiotherapy for head and neck cancers, especially grade 3 or 4 mucositis. Occurrence may result in drop-out from treatment, thereby reducing survival. We aimed to clarify the effectiveness and safety of rebamipide mouthwash for oral mucositis in patients wi...
Published in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Standard treatment of epidermoid anal cancer is 5-fluorouracil (5FU) and mitomycin C (MMC) based chemoradiotherapy (CRT). This phase I study aims to evaluate the addition of panitumumab (Pmab) to CRT and to determine the maximum tolerated dose (MTD) of Pmab and 5-FU in combination with CRT. Immunocompetent patients with locally advanced tumour with...
Published in Annals of coloproctology
The aim of this study was to assess oncological outcomes of postoperative radiotherapy plus chemotherapy (CRT) versus chemotherapy alone (CTx) in stage II or III upper rectal cancer patients who underwent curative surgery. We retrospectively reviewed 263 consecutive patients with pathologic stage II or III upper rectal cancer who underwent primary ...
