BACKGROUND: The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development. MAIN BODY: This selection of highlights provides commentary on 21 different topics selected by each coauthoring Editorial Board member addressing a variety...
BACKGROUND: The molecular chaperone, Hsp90, is a key player in the protein quality control system that maintains homeostasis under cellular stress conditions. It is a homodimer with ATP-dependent activity, and is a prominent member of the chaperone machinery that stabilizes, matures and (re)folds an extensive list of client proteins. Hsp90 occurs a...
status: published
status: published
Protein crystallography and biochemical assays reveal that the organometallic drug, [Ru(eta(6)-p-cymene)Cl-2(pta)] (RAPTA-C), preferentially binds to nucleosomal histone proteins in chromatin. To better understand the binding mechanism we report here a mass spectrometric-based competitive binding study between a model peptide from the acidic patch ...
status: published
Methodological bias can directly affect the interpretation of research data. Studies reporting on excavated skeletons represent a valuable source of information in medicine, dentistry, archaeology and anthropology, and forensic sciences. However, these studies represent a specific setting with their own methodology, for which no quality assessment ...
A series of UiO-66 materials with different functional groups (-H, -NH2, and -NO2) have been evaluated for the adsorption and release of a common ocular drug such as brimonidine tartrate. UiO-66 samples were synthesized under solvothermal conditions and activated by solvent exchange with ethanol. Experimental results suggest that the incorporation ...
By introducing Bronsted acidic ionic liquids (ILs), two dual-emitting lanthanide metal-organic complexes (Ln-MOCs) of {[Ln(imdc)-(CH3OH)(H2O)3]Cl2}n (LnIMDC, Ln = Eu and Tb, imdc = 1,3-bis(carboxymethyl)imidazolium ion) were first prepared under solvothermal conditions. The crystal structures of LnIMDC were measured by single-crystal X-ray diffract...
By introducing Bronsted acidic ionic liquids (ILs), two dual-emitting lanthanide metal-organic complexes (Ln-MOCs) of {[Ln(imdc)-(CH3OH)(H2O)3]Cl2}n (LnIMDC, Ln = Eu and Tb, imdc = 1,3-bis(carboxymethyl)imidazolium ion) were first prepared under solvothermal conditions. The crystal structures of LnIMDC were measured by single-crystal X-ray diffract...
