Demir, Selim Turan, Ibrahim Aliyazicioglu, Rezzan Yaman, Serap Ozer Aliyazicioglu, Yuksel
Published in
Journal of pharmaceutical analysis
Primula vulgaris belongs to the genus Primula, members of which are frequently used in folk medicine. Various studies have investigated the cytotoxic effect of different Primula species, but there have been limited studies on the cytotoxic effect of P. vulgaris. The aim of this study was to investigate the cytotoxic effects, and possible mechanisms...
Zeng, Feng Huang, Liangliang Cheng, Xiaoming Yang, Xiaoli Li, Taolang Feng, Guoli Tang, Yingqi Yang, Yan
Published in
Cancer Cell International
BackgroundThe aim of this study was to investigate the role of LAG1 longevity-assurance homologue 2 (LASS2) in papillary thyroid cancer (PTC).MethodsImmunohistochemistry staining was conducted to explore the expression levels of LASS2 in PTC tissues and adjacent normal thyroid tissues and nodular goiter tissues. Western blotting and RT-qPCR were pe...
Zhang, Jin Liu, Jianhui Ren, Lihua Wei, Jialiu Zhang, Feng Li, Yanbo Guo, Caixia Duan, Junchao Sun, Zhiwei Zhou, Xianqing
...
Published in
Chemosphere
The potential health hazards of silica nanoparticles (SiNPs) have attracted more and more attentions. Researches had shown that SiNPs could damage seminiferous epithelium and reduce the quantity and quality of sperms, however the specific mechanism of male reproductive toxicity induced by SiNPs still unclear. So we designed to investigate the mecha...
Wu, Ruifan Liu, Youhua Yao, Yongxi Zhao, Yuanling Bi, Zhen Jiang, Qin Liu, Qing Cai, Min Wang, Fengqin Wang, Yizhen
...
Published in
Biochimica et biophysica acta. Molecular and cell biology of lipids
N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in eukaryotes. Loss of m6A demethylase FTO increases m6A levels and inhibits adipogenesis of preadipocytes. However, its underlying mechanism remains elusive. Here, we demonstrated that silencing FTO inhibited adipogenesis of preadipocytes through impairing cell cycle progres...
Pérez, Francisco J. Noriega, Ximena
Published in
Planta
Main conclusionBud-break assays under forced growth conditions suggest that a drop in ABA content and an increase in sugars are common features in the sprouting of paradormant (PD) and endodormant (ED) grapevine buds. However, increases in cell division and in respiration are unique characteristics of the ED budding.In tropical and subtropical regi...
Hanžić, Nikolina Horvat, Anđela Bibić, Juraj Unfried, Klaus Jurkin, Tanja Dražić, Goran Marijanović, Inga Slade, Neda Gotić, Marijan
Published in
Materials science & engineering. C, Materials for biological applications
Gold nanoparticles (AuNPs) were synthesized in the presence of citrate (Au-CIT), glutathione (Au-GSH) and aminodextran (Au-DEX) in order to modify AuNPs surfaces and to increase their cellular uptake in the breast cancer cells MDA-MB-231. AuNPs were characterized with respect to their particle size, shape and colloidal stability in an aqueous solut...
Villa-Hernández, Sara Bermejo, Rodrigo
Published in
Current Genetics
Proliferating cells need to accurately duplicate and pass their genetic material on to daughter cells. Problems during replication and partition challenge the structural and numerical integrity of chromosomes. Diverse mechanisms, as the DNA replication checkpoint, survey the correct progression of replication and couple it with other cell cycle eve...
Hong, Nan Hee Tak, Yeong Jin Rhim, Hyangshuk Kang, Seongman
Published in
Genes & Genomics
Regulation of cell cycle arrest and re-entry triggered by DNA damage is vital for cell division and growth and is also involved in cell survival. UV radiation can generate lesions in the DNA, which results in cell cycle arrest and the induction of the DNA repair process. However, the mechanism of promoting cell cycle progression following DNA repai...
He, Peng Billy, Kirunda John Ma, Huishu Jia, Ya Yang, Lijian
Published in
Nonlinear Dynamics
E2F is a key transcription factor in the cell cycle network that regulates cell transition from G1 to S phase. MiR-17-92 plays an important role in the expression of E2F and regulates the progression of the cell cycle. Based on the Rb-E2F-MiR cell cycle network, we found that introduction of miR-17-92 in the network prolongs the cell cycle transiti...
Caller, Laura Grace
The potentially oncogenic human pathogen BK Polyomavirus (BKPyV) was first identified in 1971 and has since been associated with a number of diseases primarily in immunosuppressed patients. Infection is established in early life and by adulthood up to 90% of populations show seroconversion for the major capsid protein VP1. Despite this infections a...
