Horemans, Steff Pitoulias, Matthaios Holland, Alexandria Pateau, Emilie Lechaplais, Christophe Ekaterina, Dariy Perret, Alain Soultanas, Panos Janniere, Laurent
Published in
BMC Biology
Background In all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate genome duplication prior to cell division. Failures in this regulation cause DNA damage with potentially disastrous consequences for cell viability and human health, including cancer. To cope with these th...
Zhang, Mengjun Liu, Yuan Yin, Yue Sun, Zhenxing Wang, Yan Zhang, Zexue Li, Fei Chen, Xiuwei
Published in
Molecular Medicine
Background Ovarian cancer is one of the important factors that seriously threaten women's health and its morbidity and mortality ranks eighth among female cancers in the world. It is critical to identify potential and promising biomarkers for prognostic evaluation and molecular therapy of OV. Ubiquitin-conjugating enzyme E2S (UBE2S), a potential on...
Su, Wei Feng, Baijie Hu, Lina Guo, Xianzhi Yu, Minghua
Published in
BMC Cancer
Mucin 3A (MUC3A) is overexpressed in colorectal cancer (CRC) and associated with poor prognosis, but the related mechanism remains unclear. Our study found that MUC3A promotes the progression of CRC by activating the PI3K/Akt/mTOR signaling pathway. Knockout of MUC3A significantly inhibited the proliferation of CRC cells and induced G1 phase arrest...
Li, Xiaoya Michels, Birgitta Elisabeth Tosun, Oyku Ece Jung, Janine Kappes, Jolane Ibing, Susanne Nataraj, Nishanth Belugali Sahay, Shashwat Schneider, Martin Wörner, Angelika
...
Published in
Journal of Experimental & Clinical Cancer Research : CR
Background MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby extending the phenotypic impact of the respective common pre-miRNA. However, for most miRNAs, express...
Voelkel-Johnson, Christina
Published in
Seminars in cancer biology
The aberrant biology of polyploid giant cancer cells (PGCC) includes dysregulation of the cell cycle, induction of stress responses, and dedifferentiation, all of which are likely accompanied by adaptations in biophysical properties and metabolic activity. Sphingolipids are the second largest class of membrane lipids and play important roles in man...
He, Yifeng Li, Haijian He, Yunhe Lu, Caijie Zhu, Peiyi Li, Mingyi Duan, Juan Fang, Zhixin
Published in
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Hepatic oval cells have strong proliferation and differentiation capabilities and are activated when chronic liver injury occurs or when liver function is severely impaired. Peroxisome proliferation-activated receptors (PPARs) are ligand-dependent, sequence-specific nuclear transcription factors. PPARγ is closely related to liver diseases (such as ...
Zhao, Lianzheng Liao, Hongwei Wang, Xiaodan Chen, Ye-Guang
Published in
Cell Regeneration
Geng, Wenting Qiu, Mengru Zhang, Dongbin Li, Peng Sun, Gangyi Zhou, Xi
Published in
American Journal of Translational Research
Objective: Lung cancer remains one of the common cancers worldwide. Both LncRNA PCAT7 and miR-486-5p are tightly correlated with NSCLC. However, the relationship between PCAT7 and miR-486-5p and the detailed mechanisms underlying the effect of PCAT7 on NSCLC are not discovered yet. Methods: GEPIA and ENCORI databases were used to determine the expr...
Han, Peiyu Shen, Li Nan, Nan Zhou, Renwu Li, Tianci Dai, Xiaofeng
Published in
International Journal of Biological Sciences
Objectives: Vaccination still remains as the most effective approach for preventing infectious diseases such as those caused by virus infection, with cell-based vaccine manufacturing being one flexible solution regarding the spectrum of infectious disorders it can prevent. Rapid cell-based virus propagation can enable high yield of vaccines against...
Basak, Trishita Ain, Rupasri
Published in
Stem Cell Research & Therapy
Background Trophoblast stem cells (TSCs), the precursors of trophoblast cells of placenta, possess the potential to differentiate into various trophoblastic subtypes in vitro. Establishment of extraembryonic trophoblastic lineage is preceded by the “outside versus inside” positional information in preimplantation embryos, critically synchronized by...
