Yuan, Jian-Qi Yuan, Yang Pan, Shan-Shan Cai, Ke
Published in
The Journal of Physiological Sciences
Exercise has been reported to induce autophagy. We hypothesized that exercise preconditioning (EP)-related autophagy in cardiomyocytes could be attributed to intermittent ischemia–hypoxia, allowing the heart to be protected for subsequent high-intensity exercise (HE). We applied approaches, chromotrope-2R brilliant green (C-2R BG) staining and plas...
Ghanimati, Reza Rajabi, Hamid Ramezani, Fatemeh Ramez, Maral Bapiran, Mohsen Nasirinezhad, Farinaz
Published in
BMC Cardiovascular Disorders
BackgroundExercise training is known as a practical way to increase cardioprotection against stress, and it seems that stem cell recruitment is one of its mechanisms. The purpose of the present study was to investigate the effect of preconditioning with High-intensity interval training (HIIT) on tissue levels of G-CSF, its receptor and C-Kit follow...
Koyama, Takashi Munakata, Masahito Akima, Takashi Kanki, Hideaki
Published in
Cardiology
Background: We recently reported a new approach, namely postconditioning with lactate-enriched blood (PCLeB), for cardioprotection in patients with ST-segment elevation myocardial infarction (STEMI). Objectives: We examined the effects of PCLeB on plasma NT-proBNP levels months after myocardial infarction (MI). Methods: The study included consecuti...
Lewis, Rebecca Li, Jiaqi McCormick, Peter J L-H Huang, Christopher Jeevaratnam, Kamalan
Published in
International journal of cardiology. Heart & vasculature
Sigma-1 receptors are ligand-regulated chaperone proteins, involved in several cellular mechanisms. The aim of this systematic review was to examine the effects that the sigma-1 receptor has on the cardiovascular system. The interaction targets and proposed mechanisms of action of sigma-1 receptors were explored, with the aim of determining if the ...
Jeong, Han Saem Park, Chi-Yeon Kim, Jong-Ho Joo, Hyung Joon Choi, Seung-Cheol Choi, Ji-Hyun Lim, I-Rang Park, Jae Hyoung Hong, Soon Jun Lim, Do-Sun
...
Published in
Molecular Medicine
BackgroundSca-1+ cardiac stem cells and their limited proliferative potential were major limiting factors for use in various studies.MethodsTherefore, the effects of sphere genetically engineered cardiac stem cells (S-GECS) inserted with telomerase reverse transcriptase (TERT) were investigated to examine cardiomyocyte survival under hypoxic condit...
Corydon, Krestine Kjeldsen Matchkov, Vladimir Fais, Rafael Abramochkin, Denis Hedegaard, Elise Røge Comerma-Steffensen, Simon Simonsen, Ulf
Published in
European journal of pharmacology
Recently, we found cardioprotective effects of ischemic preconditioning (IPC), and from a blocker of KCNQ voltage-gated K+ channels (KV7), XE991 (10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone), in isolated rat hearts. The purpose of the present study was to investigate the cardiovascular effects of IPC and XE991 and whether they are cardioprotec...
Cheng, Richard K Yang, Eric H
Published in
Trends in cardiovascular medicine
Smani, Tarik Mayoral-Gonzalez, Isabel Galeano-Otero, Isabel Gallardo-Castillo, Isabel Rosado, Juan A Ordoñez, Antonio Hmadcha, Abdelkrim
Published in
Advances in experimental medicine and biology
The Ischemic Heart Disease (IHD) is considered a clinical condition characterized by myocardial ischemia causing an imbalance between myocardial blood supply and demand, leading to morbidity and mortality across the worldwide. Prompt diagnostic and prognostic represents key factors for the treatment and reduction of the mortality rate. Therefore, o...
Tyagi, Sakshi Kaur, Simranjot Singh, Nirmal Jaggi, Amteshwar Singh
Published in
Iranian Journal of Basic Medical Sciences
Objective(s): To study the effect of acute and repeated stress on cardioprotection-induced by remote ischemic preconditioning (RIPC). Materials and Methods: RIPC was induced by giving 4 short cycles of ischemia and reperfusion, each consisting of five min. The Langendorff’s apparatus was used to perfuse the isolated rat hearts by subjecting the hea...
Agrimi, Jacopo Baroni, Carlotta Anakor, Ekene Lionetti, Vincenzo
Published in
Current medicinal chemistry
The number of obese patients undergoing cardiac and noncardiac surgery is rapidly increasing because they are more prone to concomitant diseases, such as diabetes, thrombosis, sleep-disordered breathing, cardiovascular and cerebrovascular disorders. Even if guidelines are already available to manage anesthesia and surgery of obese patients, the ass...
