Koka, Saisudha Xi, Lei Kukreja, Rakesh C
Published in
Molecular and cellular biochemistry
Patients with metabolic syndrome (MetS) often exhibit generalized endothelial and cardiac dysfunction with decreased nitric oxide (NO) production and/or bioavailability. Since phosphodiesterase 5 (PDE5) inhibitors restore NO signaling, we hypothesized that chronic treatment with long-acting PDE5 inhibitor tadalafil may enhance plasma NO levels and ...
Hermidorff, Milla Marques de Assis, Leonardo Vinícius Monteiro Rodrigues, Joel Alves Soares, Leôncio Lopes Andrade, Milton Hércules Guerra Natali, Antônio José Isoldi, Mauro Cesar
Published in
Heart and vessels
Activation of mineralocorticoid receptor antagonists (MRAs) is cardioprotective; however, this property is lost upon blockade or inactivation of adenosine (ADO) receptor A2b. In this study, we investigated whether the effects of MRAs are mediated by an interaction between cardioprotective ADO receptors A1 and A3. Spironolactone (SPI) or eplerenone ...
Zhang, Tao Yang, Wen-Xiu Wang, Ya-Ling Yuan, Jing Qian, Yi Sun, Qin-Mei Yu, Mei-Ling Fu, Shu-Ping Xu, Bin Lu, Sheng-Feng
...
Published in
Life sciences
Electro-acupuncture pretreatment (EAP) plays a protective role in myocardial ischemia (MI) injury. However, the underlying mechanism remains unclear. A growing body of evidence suggests postinfarction inflammatory response directly affects the remodeling of ventricular function. The purpose of this study was to investigate whether EAP alleviates MI...
Hausenloy, Derek J. Ntsekhe, Mpiko Yellon, Derek M.
Published in
Basic Research in Cardiology
Graffagnino, Jason Kondapalli, Lavanya Arora, Garima Hawi, Riem Lenneman, Carrie G.
Published in
Current Treatment Options in Oncology
Cardiovascular disease is a leading cause of death among cancer survivors. While the field of cardiology as a whole is driven by evidence generated through robust clinical trials, data in cardio-oncology is limited to a relatively small number of prospective clinical trials with heterogeneous groups of cancer patients. In addition, many pharmaceuti...
Boisguérin, Prisca Covinhes, Aurélie Gallot, Laura Barrère, Christian Vincent, Anne Busson, Muriel Piot, Christophe Nargeot, Joël Lebleu, Bernard Barrère-Lemaire, Stéphanie
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Published in
Cardiovascular research
Regulated cell death is a main contributor of myocardial ischaemia-reperfusion (IR) injury during acute myocardial infarction. In this context, targeting apoptosis could be a potent therapeutical strategy. In a previous study, we showed that DAXX (death-associated protein) was essential for transducing the FAS-dependent apoptotic signal during IR i...
Haller, Paul M Vargas, Kris G Haller, Maria C Piackova, Edita Wojta, Johann Gyöngyösi, Mariann Gersh, Bernard J Kiss, Attila Podesser, Bruno K Huber, Kurt
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Published in
European heart journal. Acute cardiovascular care
The efficacy of remote ischaemic conditioning in clinical trials of ST-segment elevation myocardial infarction (STEMI) or elective percutaneous coronary intervention is controversial. We aimed to systematically review and meta-analyse whether remote ischaemic conditioning reduces myocardial damage in those patients. We searched PubMed, Embase and W...
Anna, Roehl Rolf, Rossaint Mark, Coburn
Published in
Intensive Care Medicine Experimental
The growth of the elderly population has led to an increase in patients with myocardial infarction and stroke (Wajngarten and Silva, Eur Cardiol 14: 111–115, 2019). Patients receiving treatment for ST-segment-elevation myocardial infarction (STEMI) highly profit from early reperfusion therapy under 3 h from the onset of symptoms. However, mortality...
Ye, Jing-Xue Wang, Min Wang, Rui-Ying Liu, Hai-Tao Qi, Yao-Dong Fu, Jian-Hua Zhang, Qiong Zhang, Ben-Gang Sun, Xiao-Bo
Published in
International immunopharmacology
Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent that alleviates myocardial ischaemia/reperfusion injury (MIRI), but the exact mechanisms remain elusive. The aim of this study was to investigate the potential protective effect of HSYA against MIRI through mechanisms related to NLRP3 inflammasome regulation. In this study, hypoxia/re...
Yuan, Jian-Qi Yuan, Yang Pan, Shan-Shan Cai, Ke
Published in
The Journal of Physiological Sciences
Exercise has been reported to induce autophagy. We hypothesized that exercise preconditioning (EP)-related autophagy in cardiomyocytes could be attributed to intermittent ischemia–hypoxia, allowing the heart to be protected for subsequent high-intensity exercise (HE). We applied approaches, chromotrope-2R brilliant green (C-2R BG) staining and plas...
