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with Calcium-Sensing Receptor as keyword
Modvig, Ida M Kuhre, Rune E Holst, Jens Juul
Published in
Physiological reports
Protein intake robustly stimulates the secretion of the incretin hormone, glucagon-like peptide-1 (GLP-1) but the molecular mechanisms involved are not well understood. In particular, it is unknown whether proteins stimulate secretion by activation of luminal or basolateral sensors. We characterized the mechanisms using a physiologically relevant m...
Feng, Rui Ding, Fan Mi, Xiu-Hua Liu, Shu-Fen Jiang, Ai-Ling Liu, Bi-Hui Lian, Yin Shi, Qi Wang, Yong-Jun Zhang, Yan
...
Published in
The American journal of Chinese medicine
Ligustroflavone is one major compound contained in active fraction from Fructus Ligustri Lucidi (the fruit of Ligustrum lucidum), which could regulate parathyroid hormone (PTH) levels and improve calcium balance by acting on calcium-sensing receptors (CaSR). This study aimed to explore the potency of ligustroflavone as a CaSR antagonist and its pro...
Železníková, Viera Vedralová, Marcela Kotrbová-Kozak, Anna Zoubková, Hana Černá, Marie Rychlík, Ivan
Published in
Kidney and Blood Pressure Research
Background/Aims: Calcium-Sensing Receptor (CaSR) significantly affects calcium-phosphate metabolism in kidneys, and it is implicated in the pathogenesis of diabetes mellitus (DM) due to its expression in pancreatic F-cells. The role of CaSR as one of the players in pathogenesis of chronic kidney disease (CKD) has been speculated. Methods: 158 Type ...
Hills, Claire E. Younis, Mustafa Y.G. Bennett, Jeanette Siamantouras, Eleftherios Liu, Kuo-Kang Squires, Paul E.
Published in
Cellular Physiology and Biochemistry
Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion. However, it is unknown how CaR activation improves β-cell function. Methods: Immunocytochemistry and western blotting confirmed the expression of CaR in MIN6...
