Sauer, Brian C. Chen, Wei Xu, Yizhe Shen, Jincheng Accortt, Neil A. Collier, David H. Cannon, Grant W.
Published in
Arthritis Research & Therapy
BackgroundA previous analysis of the Veterans Affairs Rheumatoid Arthritis (VARA) registry showed that more than half of the patients with rheumatoid arthritis (RA) did not receive a major therapeutic change (MTC) despite moderate or severe disease activity. We aimed to empirically determine disease activity thresholds associated with a decision by...
Keystone, Edward C Ahmad, Harris A Yazici, Yusuf Bergman, Martin J
Published in
Rheumatology (Oxford, England)
Data from two double-blind, randomized, Phase III studies were analysed to investigate the ability of Routine Assessment of Patient Index Data 3, DAS28 (CRP), modified (M)-DAS28 (CRP) and Simplified or Clinical Disease Activity Indices to predict structural damage progression in RA. This post hoc analysis included data from the 2-year Abatacept vs ...
Alsaber, Ahmad Pan, Jiazhu Al-Herz, Adeeba Alkandary, Dhary S. Al-Hurban, Adeeba Setiya, Parul
Published in
International Journal of Environmental Research and Public Health
Rheumatoid arthritis (RA) is a chronic autoimmune of an unknown etiology. Air pollution has been proposed as one of the possible risk factors associated with disease activity, although has not been extensively studied. In this study, we measured the relationship between exposure to air pollutants and RA activity. Data on RA patients were extracted ...
Tanaka, Yoshiya Smolen, Josef S. Jones, Heather Szumski, Annette Marshall, Lisa Emery, Paul
Published in
Arthritis Research & Therapy
BackgroundBiologic disease-modifying antirheumatic drugs (bDMARDs) are important options for managing rheumatoid arthritis (RA). Once patients achieve disease control, clinicians may consider dose reduction or withdrawal of the bDMARD. Results from published studies indicate that some patients will maintain remission; however, others will flare. We...
Legué, Clémence Brochard, Charlène Bessi, Grégoire Wallenhorst, Timothée Dewitte, Marie Siproudhis, Laurent Bouguen, Guillaume
Published in
Inflammatory bowel diseases
Discontinuation of antitumour necrosis factor (TNF)α therapy with perianal fistulising Crohn's disease remains controversial due to the risk of severe relapse without any clear evidence. The aim of this study was to assess the rate and type of perianal and luminal relapses following anti-TNFα discontinuation. All patients treated with anti-TNFα for...
Louis, Edouard J. Reinisch, Walter Schwartz, David A. Löfberg, Robert Robinson, Anne M. Berg, Sofie Wang, Anthony W. Maa, Jen-fue Huang, Bidan Pappalardo, Brandee
...
Published in
Advances in Therapy
IntroductionExtraintestinal manifestations (EIMs) in patients with Crohn’s disease (CD) are common and associated with additional morbidity. This study aimed to evaluate the effect of adalimumab therapy on EIM resolution and identify potential predictors of EIM resolution in adult and pediatric patients with moderate to severe CD.MethodsEIM data we...
Morris, Marc W Stewart, Samuel A Heisler, Courtney Sandborn, William J Loftus, Edward V Zello, Gordon A Fowler, Sharyle A Jones, Jennifer L
Published in
Inflammatory bowel diseases
The Crohn's Disease Activity Index (CDAI), a scoring index including patient-reported outcomes (PROs), has known limitations for measuring intestinal inflammatory disease burden. Noninvasive markers of inflammation could prove more accurate than PROs; thus, regulatory authorities are exploring the use of PROs and endoscopic data as coprimary end po...
Hasegawa, Hitoshi
Published in
Methods in molecular biology (Clifton, N.J.)
The primary goal in the treatment of rheumatoid arthritis (RA) should be achieving control of disease activity, prevention of structural damage in joints, and normalization of function. Therefore, reliable tools are necessary to evaluate RA. Here, we describe methods recently used to assess RA.
Curtis, Jeffrey R Chen, Lang Danila, Maria I Saag, Kenneth G Parham, Kathy L Cush, John J
Published in
The Journal of rheumatology
The aim of our study was to examine why real-world practices and attitudes regarding quantitative measurements of rheumatoid arthritis (RA) have received limited attention. An e-mail survey asked US rheumatologists to self-report on their use of quantitative measurements (metric). Among 439 respondents, metric rheumatologists (58%) were more likely...
Kim, Eun Soo Park, Kyung Sik Cho, Kwang Bum Kim, Kyeong Ok Jang, Byung Ik Kim, Eun Young Jung, Jin Tae Jeon, Seong Woo Jung, Min Kyu Lee, Hyun Seok
...
Published in
Journal of Crohn's & colitis
This study demonstrates that CDSD correlated well with CDAI. CDSD score of 5 is the cut-off value for clinical remission (CDAI score ≤150). Use of CDSD might permit a simple, patient-friendly assessment of CD activity, which can provide useful early-phase information on patients with CD as part of their long-term clinical assessment.
